The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders. ##STR00001##

The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders. ##STR00001##

The present application discloses a method for preparing polyester polyol comprising performing transesterification of raw materials containing inorganic oxyacid ester and polyhydric alcohol to obtain the polyester polyol. The polyester polyol obtained by the method described in the present application has higher heat resistance.

The present application discloses a method for preparing polyester polyol comprising performing transesterification of raw materials containing inorganic oxyacid ester and polyhydric alcohol to obtain the polyester polyol. The polyester polyol obtained by the method described in the present application has higher heat resistance.

This invention relates to a curable composition comprising: I. a first component comprising a resin having at least one functional group selected from the group consisting of β-ketoester and malonate functional groups, II. a second component comprising at least one curing agent having at least one aldehyde functional group, and III. a third component comprising at least one primary amine or at least one secondary amine, salts thereof, or combinations thereof.

This invention relates to a curable composition comprising: I. a first component comprising a resin having at least one functional group selected from the group consisting of β-ketoester and malonate functional groups, II. a second component comprising at least one curing agent having at least one aldehyde functional group, and III. a third component comprising at least one primary amine or at least one secondary amine, salts thereof, or combinations thereof.

The present invention provides a polyester resin and a hollow molded body containing reduced amounts of cyclic trimer and aluminum-based foreign matter, with maintained catalytic activity and a reduced catalyst cost. A polyester resin, comprising an aluminum compound and a phosphorus compound, and satisfying the following (1) to (3): (1) a content of aluminum element in the polyester resin is 9 to 19 ppm by mass, (2) a content of phosphorus element in the polyester resin is 22 to 40 ppm by mass. and (3) a mole ratio of phosphorus element to aluminum element in the polyester resin is 1.55 or more and 1.85 or less.

The present invention provides a polyester resin and a hollow molded body containing reduced amounts of cyclic trimer and aluminum-based foreign matter, with maintained catalytic activity and a reduced catalyst cost. A polyester resin, comprising an aluminum compound and a phosphorus compound, and satisfying the following (1) to (3): (1) a content of aluminum element in the polyester resin is 9 to 19 ppm by mass, (2) a content of phosphorus element in the polyester resin is 22 to 40 ppm by mass. and (3) a mole ratio of phosphorus element to aluminum element in the polyester resin is 1.55 or more and 1.85 or less.

The disclosure relates to a method for producing a drawn/ironed can, including drawing and ironing a coated metal sheet, the coated metal sheet having an inner surface coating film at least on a surface to be a can inner surface. A glass transition temperature (Tg) of a polyester resin contained in the inner surface coating film is 55° C. or higher, an ironing rate in the drawing and ironing is 40% or greater, and a processing speed during ironing in the drawing and ironing is 2000 mm/sec or higher. Thus, even in a case where a coated metal sheet having a coating film with excellent flavor sorption resistance and contains a polyester resin having a high glass transition temperature as a main component is used, occurrence of a coating film defect during molding and occurrence of coating film peeling due to heat treatment can be suppressed.

The disclosure relates to a method for producing a drawn/ironed can, including drawing and ironing a coated metal sheet, the coated metal sheet having an inner surface coating film at least on a surface to be a can inner surface. A glass transition temperature (Tg) of a polyester resin contained in the inner surface coating film is 55° C. or higher, an ironing rate in the drawing and ironing is 40% or greater, and a processing speed during ironing in the drawing and ironing is 2000 mm/sec or higher. Thus, even in a case where a coated metal sheet having a coating film with excellent flavor sorption resistance and contains a polyester resin having a high glass transition temperature as a main component is used, occurrence of a coating film defect during molding and occurrence of coating film peeling due to heat treatment can be suppressed.