A polyester and a method for manufacturing polyester are provided. The polyester comprises one or more repeating units derived from polyols and one or more repeating units derived from polybasic acids and contains phosphorus and a metal element, wherein one or more repeating units derived from polyols include a repeating unit derived from tricyclodecane dimethanol, the weight ratio of the phosphorus to the metal element ranges from 0.05 to 5.00, and the metal element is selected from the group consisting of Ti, Sn, Sb, Ge, Mn, Zn, Ca, Co, Pb, Al, Zr, and combinations thereof.

A polyester and a method for manufacturing polyester are provided. The polyester comprises one or more repeating units derived from polyols and one or more repeating units derived from polybasic acids and contains phosphorus and a metal element, wherein one or more repeating units derived from polyols include a repeating unit derived from tricyclodecane dimethanol, the weight ratio of the phosphorus to the metal element ranges from 0.05 to 5.00, and the metal element is selected from the group consisting of Ti, Sn, Sb, Ge, Mn, Zn, Ca, Co, Pb, Al, Zr, and combinations thereof.

The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

##STR00001##

The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.

##STR00001##

A method of producing a degradable material includes steps of providing δ-valerolactone 2-ethylidene-6-hepten-5-olide (EVL) or other suitable monomer; combining the EVL or other suitable monomer with a catalyst to form a reaction mixture; and subjecting the reaction mixture to conditions that will allow the EVL or other suitable monomer to react in the presence of the catalyst to thereby form a product composition including a polymer of the EVL or other suitable monomer, where the polymer is hydrolytically degradable.

A method of producing a degradable material includes steps of providing δ-valerolactone 2-ethylidene-6-hepten-5-olide (EVL) or other suitable monomer; combining the EVL or other suitable monomer with a catalyst to form a reaction mixture; and subjecting the reaction mixture to conditions that will allow the EVL or other suitable monomer to react in the presence of the catalyst to thereby form a product composition including a polymer of the EVL or other suitable monomer, where the polymer is hydrolytically degradable.

A method for synthesizing regioregular polyesters, starting from asymmetric diols, may provide the polymer ordered structure and advantageous physical-chemical properties. Such methods can make it is possible to obtain regioregular polyesters having high glass transition temperatures T.sub.g and crystalline properties. In the case in which the asymmetric diols are used in a pure enantiomeric form, with respect to the chiral carbon bound to the secondary hydroxyl, through the above-mentioned method it is possible to obtain regioregular and stereoregular polyesters, which may have thermal and crystalline properties further ameliorative with respect to non-chiral regioregular polymers.

A method for synthesizing regioregular polyesters, starting from asymmetric diols, may provide the polymer ordered structure and advantageous physical-chemical properties. Such methods can make it is possible to obtain regioregular polyesters having high glass transition temperatures T.sub.g and crystalline properties. In the case in which the asymmetric diols are used in a pure enantiomeric form, with respect to the chiral carbon bound to the secondary hydroxyl, through the above-mentioned method it is possible to obtain regioregular and stereoregular polyesters, which may have thermal and crystalline properties further ameliorative with respect to non-chiral regioregular polymers.

Disclosed is a method for preparing polylactone by ring opening, belonging to the technical fields of organic catalysis and polymer materials. The invention proposes a new catalytic mechanism, wherein an organic alcohol is used as an initiator to initiate ring opening polymerization of a cyclic monomer under the catalysis of an organic catalyst to obtain a polylactone; and the catalyst is a pyridinium salt. The present invention has the advantages of non-toxic reaction, simple conditions and controllable process; further, the invention can obtain a narrow molecular weight distribution in the absence of solution polymerization, and can effectively inhibit the occurrence of the transesterification compared with the catalysis of 4-(N,N-dimethylamino)pyridine.

Disclosed is a method for preparing polylactone by ring opening, belonging to the technical fields of organic catalysis and polymer materials. The invention proposes a new catalytic mechanism, wherein an organic alcohol is used as an initiator to initiate ring opening polymerization of a cyclic monomer under the catalysis of an organic catalyst to obtain a polylactone; and the catalyst is a pyridinium salt. The present invention has the advantages of non-toxic reaction, simple conditions and controllable process; further, the invention can obtain a narrow molecular weight distribution in the absence of solution polymerization, and can effectively inhibit the occurrence of the transesterification compared with the catalysis of 4-(N,N-dimethylamino)pyridine.