The present disclosure is directed to certain polyethers copolymers, and polyether derivatives thereof, and methods of making and using the same. For example, the starting materials may include such species as citronellol, geraniol, dihydromyrcene, adipic acid, propanediol, ethylene glycol, glycerol, 1,9-nonanediol, and 1,6-hexanediol.

In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

To provide a fluorinated ether compound, a fluorinated ether composition and a coating liquid that are able to form a surface layer which is excellent in water/oil repellency, abrasion resistance, fingerprint stain removability, lubricity and outer appearance, and an article having such a surface layer. A fluorinated ether compound represented by A.sup.1-O(R.sup.f1O).sub.m1-Q.sup.1-[C(O)N(R.sup.1)].sub.p1R.sup.11C[R.sup.12SiR.sup.13.sub.n1X.sup.1.sub.3-n1].sub.3, wherein A.sup.1 is a C.sub.1-20 perfluoroalkyl group; R.sup.f1 is a fluoroalkylene group having no branched structure; m1 is an integer from 2 to 210; Q.sup.1 is a single bond or a fluoroalkylene group having no branched structure; R.sup.1 is a hydrogen atom, etc.; p1 is 0 or 1; R.sup.11 is a single bond, an alkylene group, etc.; R.sup.12 is an alkylene group, etc.; R.sup.13 is a monovalent hydrocarbon group, etc.; X.sup.1 is a hydrolyzable group; and n1 is an integer of from 0 to 2.

To provide a fluorinated ether compound, a fluorinated ether composition and a coating liquid that are able to form a surface layer which is excellent in water/oil repellency, abrasion resistance, fingerprint stain removability, lubricity and outer appearance, and an article having such a surface layer. A fluorinated ether compound represented by A.sup.1-O(R.sup.f1O).sub.m1-Q.sup.1-[C(O)N(R.sup.1)].sub.p1R.sup.11C[R.sup.12SiR.sup.13.sub.n1X.sup.1.sub.3-n1].sub.3, wherein A.sup.1 is a C.sub.1-20 perfluoroalkyl group; R.sup.f1 is a fluoroalkylene group having no branched structure; m1 is an integer from 2 to 210; Q.sup.1 is a single bond or a fluoroalkylene group having no branched structure; R.sup.1 is a hydrogen atom, etc.; p1 is 0 or 1; R.sup.11 is a single bond, an alkylene group, etc.; R.sup.12 is an alkylene group, etc.; R.sup.13 is a monovalent hydrocarbon group, etc.; X.sup.1 is a hydrolyzable group; and n1 is an integer of from 0 to 2.

A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1):

##STR00001##

wherein R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X.sup.1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.

A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1):

##STR00001##

wherein R.sup.1 and R.sup.6 are each independently a hydrogen atom or a hydrocarbon group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X.sup.1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z.sup.1 and Z.sup.2 are each independently a selected divalent spacer.

The present invention relates to elastomeric thermoplastic polymers (ETP) and especially technical polymers with high added value used in varied sectors, such as electronics, motor vehicles or sport. The present invention more particularly relates to copolymers containing polyether blocks and polyamide blocks, abbreviated as PEBA, which have good antistatic properties. Even more particularly, the invention relates to a copolymer containing at least one polyamide (PA) block, at least one polyethylene glycol (PEG) block and at least one block that is more hydrophobic than the PEG block. A subject of the invention is also a process for synthesizing such thermoplastic elastomers which have good antistatic properties and the use thereof in any type of thermoplastic polymer matrix in order to afford this matrix antistatic properties.

The present invention relates to elastomeric thermoplastic polymers (ETP) and especially technical polymers with high added value used in varied sectors, such as electronics, motor vehicles or sport. The present invention more particularly relates to copolymers containing polyether blocks and polyamide blocks, abbreviated as PEBA, which have good antistatic properties. Even more particularly, the invention relates to a copolymer containing at least one polyamide (PA) block, at least one polyethylene glycol (PEG) block and at least one block that is more hydrophobic than the PEG block. A subject of the invention is also a process for synthesizing such thermoplastic elastomers which have good antistatic properties and the use thereof in any type of thermoplastic polymer matrix in order to afford this matrix antistatic properties.

Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.

Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.