A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure:

##STR00001##

wherein X.sup.1 and Y.sup.1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule. R.sup.1 is a hydrocarbon group or the like. n is an integer of 3 to 72. A.sup.1 represents -L.sup.1-(CH.sub.2).sub.m1 or the like, L.sup.1 and L.sup.2 represent each an ether bond or the like, and m1 and m2 each independently represent an integer of 1 to 5. B.sup.1 represents -L.sup.3-(CH.sub.2).sub.m3 or the like, L.sup.3 and L.sup.4 represent an amide bond or the like, and m3 and m4 each independently represent an integer of 1 to 5. Also disclosed is an antibody-drug conjugate including the heterobifunctional monodispersed polyethylene glycol.

A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).

A functional polymer including at least two different types of side chains, having the general formula (1), ##STR00001##
wherein A is an at least monosubstituted alkylene or arylene group; B is an amide, ester or ether group and n is 0 or 1; F is selected from: an ester, secondary amine, amide, ether, thio ether, thio ester, and may be the same or different for the different side chains; D is a side chain intended to reversible bind to a substrate or has a coating function; E is a side chain intended to irreversible bind to a substrate, the side chain E and polymer includes 1 to 10 different side chains D and 1 to 10 different side chains E, but at least one of each, and includes a plurality of each type, whereby the different types of side chains are randomly or regularly distributed in the polymer.

A functional polymer including at least two different types of side chains, having the general formula (1), ##STR00001##
wherein A is an at least monosubstituted alkylene or arylene group; B is an amide, ester or ether group and n is 0 or 1; F is selected from: an ester, secondary amine, amide, ether, thio ether, thio ester, and may be the same or different for the different side chains; D is a side chain intended to reversible bind to a substrate or has a coating function; E is a side chain intended to irreversible bind to a substrate, the side chain E and polymer includes 1 to 10 different side chains D and 1 to 10 different side chains E, but at least one of each, and includes a plurality of each type, whereby the different types of side chains are randomly or regularly distributed in the polymer.

Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.

Methods for preparing active carbonate esters of water-soluble polymers are provided. Also provided are other methods related to the active carbonate esters of water-soluble polymers, as well as corresponding compositions.

The invention relates to polyesters of the following general formula, wherein the residues R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5a (as a special case of residue R.sup.5), R.sup.6, R.sup.7 and R.sup.8 are free of carboxy, hydroxy, thiol, imino, and primary and secondary amino groups, the residues R.sup.5b (as a special case of R.sup.5) and R.sup.9 contain hydroxyl groups, 10 to 100 mol % of which can be present in salt form analogously to polymers or otherwise capped, u=0 or 1, v=1 to 60 and w=1 to 20. The invention further relates to wetting agents and dispersants that contain the aforementioned polyesters or consist thereof and to a method for producing said wetting agents and dispersants, to the use of the polyesters and reaction products of the method according to the invention as wetting agents and dispersants, and to compositions containing the polyesters, wetting agents and/or dispersants or reaction products of the method according to the invention and particulate solids.

##STR00001##

A polymer electrolyte composition includes a hard polymer segment covalently bound to an ionically-conducting segment, and a salt that includes an element M selected from an alkali metal, an alkaline earth metal, zinc, and aluminum. The hard polymer segment has a glass transition temperature (T.sub.g) greater than or equal to 110 C., or a melting temperature (T.sub.m) greater than 110 C. The ionically-conducting segment has a molecular weight of 800 to 10,000 g/mol. The polymer electrolyte composition has an ionic conductivity for an M ion greater than or equal to 110.sup.8 S/cm at 25 C. Methods for the preparation of the polymer electrolyte composition are also provided, as are articles (e.g., electrochemical cells and energy storage devices) that contain the polymer electrolyte composition.

A polymer electrolyte composition includes a hard polymer segment covalently bound to an ionically-conducting segment, and a salt that includes an element M selected from an alkali metal, an alkaline earth metal, zinc, and aluminum. The hard polymer segment has a glass transition temperature (T.sub.g) greater than or equal to 110 C., or a melting temperature (T.sub.m) greater than 110 C. The ionically-conducting segment has a molecular weight of 800 to 10,000 g/mol. The polymer electrolyte composition has an ionic conductivity for an M ion greater than or equal to 110.sup.8 S/cm at 25 C. Methods for the preparation of the polymer electrolyte composition are also provided, as are articles (e.g., electrochemical cells and energy storage devices) that contain the polymer electrolyte composition.

A method for producing a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end, a polymerization initiator for use in the method, and a precursor of the polymerization initiator are provided. The present invention provides: a method for producing a polyalkylene glycol derivative having an amino group at an end, using, as a polymerization initiator, a compound represented by the general formula (I); a compound represented by the following general formula (I); and a precursor thereof: ##STR00001## wherein R.sub.A.sup.1a and R.sub.A.sup.1b each independently represent a protective group of the amino group, or one of R.sub.A.sup.1a and R.sub.A.sup.1b represents H and the other represents a protective group of the amino group, or R.sub.A.sup.1a and R.sub.A.sup.1b bind to each other to represent a cyclic protective group forming a ring; R.sub.A.sup.2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; R.sub.A.sup.3 represents a single bond, or a linear, branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms, and the hydrocarbon group may contain a heteroatom; the total number of carbon atoms (or the total number of carbon atoms and heteroatoms) of R.sub.A.sup.2 and R.sub.A.sup.3 is 4 or more; and M represents an alkali metal.