A rubber composition based at least on a reinforcing filler comprising a content of silica of greater than or equal to 80 phr and on an elastomer matrix comprising a content of a modified diene elastomer of greater than or equal to 75 phr is provided. The modified diene elastomer includes macromolecules comprising, within their structure, a linear or branched polyether block comprising, at each of the two ends of the block, a branch point to which up to three diene elastomer branches and up to three —OR groups are bonded, R representing, independently of one another, a C.sub.1-C.sub.8 alkyl substituent or a hydrogen atom

b—the. The copolymer is composed: of at least 20% of branched macromolecules comprising a polyether block to which at least three diene elastomer blocks are bonded, of at most 80% of linear macromolecules, and
d—each of the branch points includes a silicon atom.

A polyether compound having a cationic group and two or more chain end groups and, wherein all of the chain end groups are any of a hydroxyl group and an azide group is provided.

The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.

The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.

The present invention provides, among other things, methods for preparing functionalized and other polymers from polymer alcohols such as poly(ethylene glycol)s. In addition, polymer compositions, conjugates, polymeric reagents, are also provided.

The present invention relates to a block copolymer, comprising a hydrophilic first block, a hydrophobic second block, and a functional group capable of specifically binding to thiol.

Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.

This invention is to develop a production method for a cell culture carrier comprising a hydrogel having high shape retainability, and cell culture carrier production device, and to provide a structure composed of a cell culture carrier produced using the same.

The production method comprises a retention step of retaining on a support material a first solution containing a multiple branching polymer comprising polyethylene glycol as the backbone, and having at least one functional group which is one of a nucleophilic functional group and an electrophilic functional group at a side chain(s) and/or a terminal(s), and a gel formation step of forming one or more dot-shaped hydrogels in which a second solution containing a multiple branching polymer comprising polyethylene glycol as the backbone, and having at least one functional group which is the other one of a nucleophilic functional group and an electrophilic functional group at a side chain and/or a terminal, is discharged by a droplet discharge device to land in contact with the first solution retained on the support material.

In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

Embodiments are directed towards a process for producing a (poly)alkylene glycol monoalkyl ether. The process includes providing an admixture of a crystalline metallosilicate molecular sieve catalyst and an oxide of a metal and reacting in a liquid phase process an olefin and a (poly)alkylene glycol in the presence of the admixture to yield the (poly)alkylene glycol monoalkyl ether. Reacting the olefin and the (poly)alkylene glycol in the presence of the admixture is at a temperature of 80° C. to 200° C.