C08G2261/522

Blue-Excitable Water-Solvated Polymeric Dyes
20240240025 · 2024-07-18 ·

Water solvated polymeric dyes and polymeric tandem dyes having a blue excitation spectrum are provided. The polymeric dyes are conjugated polymers that can include a thiophene-containing co-monomer. The polymeric tandem dyes further include a signaling chromophore covalently linked to the conjugated polymer in energy-receiving proximity therewith. Also provided are labelled specific binding members that include the subject polymeric dyes. Methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule in which the subject polymeric dyes find use are also provided. Systems and kits for practicing the subject methods are also provided.

MECHANOCHROMIC LUMINESCENT MATERIAL, MECHANOCHROMIC RESIN OBTAINED BY CROSSLINKING MECHANOCHROMIC LUMINESCENT MATERIAL, METHOD FOR PRODUCING MECHANOCHROMIC LUMINESCENT MATERIAL, AND METHOD FOR PRODUCING MECHANOCHROMIC

Provided is a mechanochromic resin by which a stress applied to a material can be visualized in real time, and a mechanochromic luminescent material that is used in the synthesis of the mechanochromic resin. Stress can be visualized in real time by means of a mechanochromic luminescent material represented by formula (1) or formula (2) and a mechanochromic resin obtained by crosslinking the mechanochromic luminescent material. [Chemical formula 1] (In the formula, Y.sub.1 and Y.sub.2 each denote a substituent group that inhibits aggregation of the mechanochromic luminescent material represented by formula (1), and Y.sub.1 and Y.sub.2 may be same as or different from each other. Z.sub.1 and Z.sub.2 each denote a polymerizable group, and may be same as or different from each other.) [Chemical formula 2] (In the formula, Y.sub.1 and Y.sub.2 each denote a substituent group that inhibits aggregation of the mechanochromic luminescent material represented by formula (2), and Y.sub.1 and Y.sub.2 may be same as or different from each other. Z.sub.1 and Z.sub.2 each denote a polymerizable group, and may be same as or different from each other.)

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Fluorescent Methods and Materials for Directed Biomarker Signal Amplification

Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

CORE-TO-SURFACE POLYMERIZATION FOR THE SYNTHESIS OF STAR POLYMERS AND USES THEREOF
20190030067 · 2019-01-31 ·

Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

DIBENZOSILOLE MONOMERS AND POLYMERS AND METHODS FOR THEIR PREPARATION AND USE

Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

Fluorescent methods and materials for directed biomarker signal amplification

Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

Dibenzosilole monomers and polymers and methods for their preparation and use

Water-soluble, conjugated polymers containing one or more dibenzosilole monomer residues, as well as compositions, kits, and methods of making and using such polymers are disclosed. Also disclosed are dibenzosilole derivatives substituted with one or more water-solubilizing groups, and methods of making and using such derivatives to prepare water-soluble dibenzosilole polymers.

CONJUGATED POLYMER NANOPARTICLES, METHODS OF USING, AND METHODS OF MAKING

Embodiments of the present disclosure provide for conjugated polymer nanoparticle, method of making conjugated polymer nanoparticles, method of using conjugated polymer nanoparticle, polymers, and the like.

Polyfluoreno[4,5-cde]oxepine Conjugates and Their Use in Methods of Analyte Detection

The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.

ORGANIC LIGHT-EMITTING DEVICE

An organic light-emitting device comprising an anode (101), a cathode (105) and an homogeneous organic light-emitting layer (103) between the anode and the cathode wherein: the light-emitting layer comprises a first light-emitting material mixed with an inert material; the inert material has a HOMO level (HOMO.sub.IM) that is further from vacuum than a HOMO level (HOMO.sub.LEM) of the first light-emitting material and a LUMO level (LUMO.sub.IM) that is closer to vacuum than a LUMO level(LUMO.sub.LEM) of the first light-emitting material; and the inert material comprises up to 25 weight % of the light-emitting layer.