Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

The invention provides polyglycerol alkoxylate esters and for the preparation and use thereof.

The invention relates to a hyperbranched polymer comprising: a) a hyperbranched polycondensate with hydroxyl end groups, amino end groups, or a combination thereof condensed to b) one or more linking groups connected to c1) one or more polyethylene glycol monomethyl ethers and c2) one or more poly(C.sub.2-C.sub.3)alkylene glycol mono-(C.sub.8-C.sub.22)-alkyl ethers, wherein the weight ratio of components c1):c2) is from 9:1 to 1:9. It further relates to a process for producing the polymer, to a composition comprising the polymer and an active ingredient, and to a method for controlling phytopathogenic fungi or undesired vegetation or insect or acarid infestations or for regulating the growth of plants.

The present invention provides an alkynyl multi-arm polyethylene glycol derivative having a structure of a general formula I or general formula X VIII. In the derivative, X1, X2, X3 and X4 are linking groups, F1, F2, F3 and F4 are end groups, the end groups may be the same or may also be different, and are selected from: hydroxy, carboxyl, ester group, amino, alkynyl or the like, at least one of the end groups is alkynyl, and PEG is the same or different (CH.sub.2CH.sub.2O).sub.m, wherein m is an integer ranging from 3 to 250, and l is an integer greater than or equal to 1. The multi-arm polyethylene glycol derivatives have stronger application flexibility, and have good application prospect in aspects such as organic synthesis, medicine synthesis and medical instruments. ##STR00001##

Described herein are substituted polyetheramines with a low melting point which are obtainable by condensation of at least two N-(hydroxyalkyl)amines to obtain a polyetheramine and subsequent reaction of at least one remaining hydroxy group and/or, if present, at least one secondary amino group of said polyetheramine with ethylene oxide and at least one further alkylene oxide to obtain a substituted polyetheramine. Uses of such substituted polyetheramines in fields of cosmetic formulations, as crude oil emulsion brakers, in pigment dispersions of ink jets, in electro paintings, or in cementitious compositions as well as methods wherein said substituted polyetheramines are used in said fields are described herein.

A polyether dendrimer of formula (I), ##STR00001##
wherein the symbols and indices have the following meanings: each Y is independently [R.sup.1(OCH.sub.2CH.sub.2).sub.pO]; each Z is independently [R.sup.2(OCH.sub.2CH.sub.2).sub.q(OCH(CH.sub.3)CH.sub.2).sub.rO]; each R.sup.1 is independently H, CH.sub.3 or C.sub.2-C.sub.4-alkyl; each R.sup.2 is independently linear or branched C.sub.8-C.sub.22-alkyl; X is H or C.sub.1-C.sub.4-alkyl; m is 1, 2, 3, 4, 5 or 6; n, o are rational positive numbers >0, with the proviso that the sum of n and o is 2.sup.m; p is a natural number from 5 to 50; q is a natural number from 1 to 50; r is 0 or is a natural number from 1 to 30, with the proviso that 5q+r50, and denotes the bonding of the respective group to the dendron scaffold,
is useful for solubilizing sparingly-water soluble active ingredients, in particular pesticides.

Provided are a polyol glyceryl ether, and a multi-armed polyethylene glycol and the multi-armed polyethylene glycol active derivative prepared using the same. The multi-armed polyethylene glycol is formed by polymerizing ethylene oxide with the polyol glyceryl ether as an initiator, and has the structure of general formula II, wherein B is a polyol group, n is an integer between 3 and 22, PEG is the same or not the same (OCH.sub.2CH.sub.2).sub.m, and the average value of m is an integer between 3 and 250. The multi-armed polyethylene glycol has a relatively low poly-dispersity and a relatively high determined molecular weight. Also provided is a conjugate of the multi-armed polyethylene glycol active derivative and pharmaceutical molecules, a pharmaceutical composition comprising the conjugate, and a gel formed by the multi-armed polyethylene glycol active derivative. The gel can be used to prepare a sustained-release drug for prolonging the time of the drug action.

An example of a bottlebrush polymer has a polymer backbone and a plurality of individual brush moieties bonded to the polymer backbone. The individual brush moieties respectively include a crosslinked oxyamine moiety, a hydrophilic segment, and a surface adhesive terminal group.

An example of a bottlebrush polymer has a polymer backbone and a plurality of individual brush moieties bonded to the polymer backbone. The individual brush moieties respectively including a ketone, a hydrophilic segment, and a surface adhesive terminal group. The brush moieties can be functionalized and/or cross-linked.

Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups E.sub.c form a highly symmetrical octavalent group CORE.sub.0; L.sub.c connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n.sub.1 to n.sub.8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L.sub.0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

##STR00001##