The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant of FGFR3.

A method of preparing a pharmaceutical product in a single multiple chamber flexible bag. A pharmaceutical product is introduced in a liquid state into a first chamber of the flexible bag through a first port. The pharmaceutical product is lyophilized within the first chamber of the flexible bag to provide a lyophilized pharmaceutical product. The flexible bag has a second chamber and the first chamber and the second chamber are separated by a breakable seal. The second chamber further includes a reconstituting solution for reconstituting the lyophilized pharmaceutical product in the first chamber. A user may apply pressure to the flexible bag to break the seal and mix the lyophilized pharmaceutical product and the reconstituting solution to order to administer the pharmaceutical product to a patient.

An additive manufacturing composition useful as a support material for common build materials (e.g., polyamide or polyester) is comprised of a blend of an elastomer toughened styrenic polymer having discreet domains of polymerized conjugate diene dispersed within a styrenic matrix and a vinyl aromatic-maleic anhydride copolymer. The composition may be used as a support material in additive manufacturing methods such as extrusion methods (e.g., fused filament fabrication). The compositions may be tuned to realize the desired adherence to facilitate the desired support while also allowing for the mechanical removal without breakage of the underlying part or residual adhered support material.

An additive manufacturing composition useful as a support material for common build materials (e.g., polyamide or polyester) is comprised of a blend of an elastomer toughened styrenic polymer having discreet domains of polymerized conjugate diene dispersed within a styrenic matrix and a vinyl aromatic-maleic anhydride copolymer. The composition may be used as a support material in additive manufacturing methods such as extrusion methods (e.g., fused filament fabrication). The compositions may be tuned to realize the desired adherence to facilitate the desired support while also allowing for the mechanical removal without breakage of the underlying part or residual adhered support material.

The present invention is related to a process for the production of a vinyl aromatic (co)polymer comprising the steps of: a) mixing a fraction (A) comprising one or more monomers selected from the group consisting of styrene, alpha-methyl styrene, acrylonitrile, methyl (meth)acrylate, (meth)acrylic acid and butadiene with a fraction (B) comprising post-consumer recycled vinyl aromatic (co)polymer, wherein the weight ratio of fraction (B) to fraction (A) is comprised between 0.01/1 and 1/1, preferably between 0.05/1 and 0.5/1 b) subjecting the resulting mixture to a free-radical polymerization and polymerizing to a monomer conversion up to 90%, to obtain a polymerized mixture comprising vinyl aromatic (co)polymer; c) vacuum devolatizing the polymerized mixture and recovering vinyl aromatic (co)polymer characterized by a weight average molecular weight comprised between 100,000 and 400,000 g/mol;
wherein one or more bromine derivative capture agents are added before, and/or during and/or after at least one of the steps a) to c); and
wherein 100 parts of one or more bromine derivative capture agents comprises at least 50 parts by weight of hydrotalcite of the formula:

[Mg.sub.1-x Al.sub.x(OH).sub.2].sup.x+(CO.sub.3).sub.x/2.mH.sub.2O

wherein: 0<x≤0.5, and m is a positive number.

The present invention is also related to expandable and extruded expanded vinyl aromatic (co)polymer compositions obtained from vinyl aromatic (co)polymers comprising post-consumer and/or post-industrial vinyl aromatic (co)polymer and to a process for the production of said expandable and extruded expanded vinyl aromatic (co)polymer compositions.

The present invention is related to a process for the production of a vinyl aromatic (co)polymer comprising the steps of: a) mixing a fraction (A) comprising one or more monomers selected from the group consisting of styrene, alpha-methyl styrene, acrylonitrile, methyl (meth)acrylate, (meth)acrylic acid and butadiene with a fraction (B) comprising post-consumer recycled vinyl aromatic (co)polymer, wherein the weight ratio of fraction (B) to fraction (A) is comprised between 0.01/1 and 1/1, preferably between 0.05/1 and 0.5/1 b) subjecting the resulting mixture to a free-radical polymerization and polymerizing to a monomer conversion up to 90%, to obtain a polymerized mixture comprising vinyl aromatic (co)polymer; c) vacuum devolatizing the polymerized mixture and recovering vinyl aromatic (co)polymer characterized by a weight average molecular weight comprised between 100,000 and 400,000 g/mol;
wherein one or more bromine derivative capture agents are added before, and/or during and/or after at least one of the steps a) to c); and
wherein 100 parts of one or more bromine derivative capture agents comprises at least 50 parts by weight of hydrotalcite of the formula:

[Mg.sub.1-x Al.sub.x(OH).sub.2].sup.x+(CO.sub.3).sub.x/2.mH.sub.2O

wherein: 0<x≤0.5, and m is a positive number.

The present invention is also related to expandable and extruded expanded vinyl aromatic (co)polymer compositions obtained from vinyl aromatic (co)polymers comprising post-consumer and/or post-industrial vinyl aromatic (co)polymer and to a process for the production of said expandable and extruded expanded vinyl aromatic (co)polymer compositions.

The present disclosure discloses a novel composition for transforming a non-biodegradable material into a decomposable material. In one embodiment, the non-biodegradable material may be plastic. The composition comprises a carbonate or a bicarbonate compound, a plant extract, a hydrating agent, and a coloring agent. The carbonate or bicarbonate compound, the plant extract and the hydrating agent are mixed in a predetermined ratio by weight along with the coloring agent and maintained in an aqueous medium. In one embodiment, the novel composition is applied on the non-biodegradable material to degrade it into a decomposable form. In another embodiment, the novel composition is mixed with the non-biodegradable material to degrade it into a decomposable form.

The present disclosure discloses a novel composition for transforming a non-biodegradable material into a decomposable material. In one embodiment, the non-biodegradable material may be plastic. The composition comprises a carbonate or a bicarbonate compound, a plant extract, a hydrating agent, and a coloring agent. The carbonate or bicarbonate compound, the plant extract and the hydrating agent are mixed in a predetermined ratio by weight along with the coloring agent and maintained in an aqueous medium. In one embodiment, the novel composition is applied on the non-biodegradable material to degrade it into a decomposable form. In another embodiment, the novel composition is mixed with the non-biodegradable material to degrade it into a decomposable form.

The present application relates to a field of a flame retardant polystyrene, and specifically discloses a preparation method for a flame retardant polystyrene. The preparation method for a flame retardant polystyrene includes the following steps: predissolving a brominated flame retardant containing a first active functional group in a reaction system of a styrene monomer to form a homogeneous solution; then, performing an end capping reaction by an olefin monomer containing a second active functional group to introduce a double bond at an end of the brominated flame retardant, so that it can be bonded to a polystyrene molecular chain by copolymerizing; performing a prepolymerization in a reactor to obtain a prepolymer; performing a post polymerization in the reactor or by extruding, to obtain a special material or a flame retardant masterbatch of the flame retardant polystyrene.