The present invention provides a tau protein aggregation inhibitor. In addition, a therapeutic agent or a preventive agent for tauopathy, including a tau protein aggregation inhibitor, and a method for screening for a tau protein aggregation inhibitor, are also provided. The problems are solved by a tau protein aggregation inhibitor including a fluorone dye or a pharmaceutically acceptable salt thereof. Moreover, the problems are also solved by a method for screening a tau protein aggregation inhibitor, wherein the method includes: (1) a step of preparing transgenic Drosophila that express a human tau protein in neurons, (2) a step of administering a candidate compound to the transgenic Drosophila, and (3) a step of measuring the motor function of the transgenic Drosophila that have been administered with the candidate compound in the step (2).

The present invention provides a tau protein aggregation inhibitor. In addition, a therapeutic agent or a preventive agent for tauopathy, including a tau protein aggregation inhibitor, and a method for screening for a tau protein aggregation inhibitor, are also provided. The problems are solved by a tau protein aggregation inhibitor including a fluorone dye or a pharmaceutically acceptable salt thereof. Moreover, the problems are also solved by a method for screening a tau protein aggregation inhibitor, wherein the method includes: (1) a step of preparing transgenic Drosophila that express a human tau protein in neurons, (2) a step of administering a candidate compound to the transgenic Drosophila, and (3) a step of measuring the motor function of the transgenic Drosophila that have been administered with the candidate compound in the step (2).

The present disclosure provides methods for identifying a hydrocarbon fuel, such as the presence and/or amounts of marker compounds having a fluorescence intensity and, through correlation, the presence and/or amounts of additive package(s) within the hydrocarbon fuel.

The present invention provides derivatized indicator compounds, such as pH indicator compounds, which can be covalently immobilized to a variety of solid substrates to produce an indicator pad. Such pads can be used to monitor water quality in variety of settings. In particular, the pads of the invention are useful in devices which monitor the quality of recreational water, such as water in swimming pools, hot tubs, and amusement park attractions, including water slides, and water-based rides. The present invention overcomes the limitations of commercially available pad chemistries.

Disclosed is a color material dispersion liquid for color filter, which has excellent heat resistance and is able to form a high-luminance coating film. The color material dispersion liquid for color filters includes (A) a color material, (B) a dispersant and (C) a solvent. The color material (A) contains (A-1) a color material represented by the following general formula (I) and (A-2) a metal lake color material of a rhodamine-based acid dye: ##STR00001##
(symbols in the general formula (I) are as described in the Description.).

Disclosed is a color material dispersion liquid for color filter, which has excellent heat resistance and is able to form a high-luminance coating film. The color material dispersion liquid for color filters includes (A) a color material, (B) a dispersant and (C) a solvent. The color material (A) contains (A-1) a color material represented by the following general formula (I) and (A-2) a metal lake color material of a rhodamine-based acid dye: ##STR00001##
(symbols in the general formula (I) are as described in the Description.).

The present invention relates to compounds of formula (A), wherein Z is NR.sup.10 or O. These compounds represent novel acridinium and xanthylium salts having an unprecedented substituted heterocyclic core. They are useful as fluorescent dyes or precursors thereof in different applications including various imaging and sensing techniques, and, in particular, as photosensitizers and hereby preferably as photocatalysts. The present invention further relates to processes for preparing the inventive compounds via 1,5-organodimetallic reagents from double directed ortho-metalation reactions or combined halogen-metal exchange/directed ortho-metalation reactions. ##STR00001##

Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

The invention provides fluorescent probes having the general formula (I)

##STR00001##

wherein X, Y, L and R.sup.1 to R.sup.4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.