A biological recording device used to monitor biological electrical activity and a method of recording neural signals. In a preferred embodiment, the biological recording device is a neural probe. The biological recording device includes a probe body with a probe shank and a recording platform that uses a delta (Δ) modulator and a delta sigma analog to digital converter (ΔΣ ADC). The Δ modulator and the ΔΣ ADC form a Δ-ΔΣ analog front end (AFE) architecture for processing biological electrical activity. A large dynamic range (DR) of neural signals, including local field potentials (LFPs) and action potentials (APs) for example, can be compressed and subsequently reconstructed.

The present invention provides a non-contact vital sign monitoring which properly detect subject's vital signs by correcting the measured signals for reflectance and variations in distance between measurements. The present invention provides for adequate sensor numbers and types to properly monitor a subject's vitals and physiological signals. Certain aspects of the invention include the use of signal scoring methods. In such embodiments, acquired data and/or information is used for scoring a signal acquired from non-contact vital monitoring assisting in the accurate measurement of various vitals of a subject, including, without limit, a subjects temperature, cardiovascular and respiratory information. The present invention provides a viable solution for at-a-distance non-contact vital sign monitoring that overcomes the shortcomings of existing solutions known in the art.

Seizure prediction systems and methods include measuring impedance within a brain of a patient to determine whether the brain is in a state indicative of a possibility of an onset of a seizure. In some embodiments, the measured impedance is compared to a predetermined threshold in order to determine whether the brain is in a state indicative of a possibility of a seizure. In other embodiments, a trend of the impedance measurements is correlated to a template. In other embodiments, a frequency component of a waveform of the impedance measurement amplitudes over time is correlated to frequency components of a template waveform. Upon detecting a state in which a seizure is likely to occur, a seizure indicator may be generated, which, in some embodiments, may be used to activate therapy delivery to the patient or, in other embodiments, activate an alarm.

This disclosure relates to selection of optimum channel in twin radars for efficient detection of cardiopulmonary signal rates. State-of-the-art solutions involve use of IQ (In-phase and Quadrature) channel radar which need continuous calibration. Distance of the radar from a subject being monitored affects performance. The present disclosure enables enhanced cardiopulmonary signal rate monitoring using a time domain approach, wherein only the data from signal reflected off the radar is considered. The solution is also time window adaptive. Signal property and radar physics-based methods have been implemented for selecting an optimum channel in twin radars thereby enhancing detection of respiration rate and breath rate.

The present invention relates to a system and method for determining a vital sign of a subject. To improve the detection of electromagnetic radiation reflected from or transmitted through skin of a subject (110) at least two differently modulated radiation sources (112, 114) are used. For both camera and single-element sensors, this allows access (after demodulation) to different mixtures of skin and non-skin reflections/transmissions that can be de-mixed and successively allows the skin-only signal to be used for photo-plethysmography, PPG, extraction. Thus, a sensor (130) detects the reflected or transmitted electromagnetic radiation and a demodulation unit (140) and processing unit (150) enable to determine a vital sign (160) from said detection signal.

An apparatus for vital sign extraction. The apparatus may receive a vital signal of a subject from a sensing device. The apparatus may also perform a preprocessing procedure on the vital signal via bandpass filtering and normalization to obtain a preprocessed signal. The apparatus may also perform a time-frequency analysis of the preprocessed signal, and estimate a heart rate of the subject from a dominant component of the preprocessed signal by finding location of a maximum spectral energy of the time-frequency analysis. In addition, the apparatus may identify guard components in the preprocessed signal in view of the dominant component, and derive a respiratory rate of the subject from a length of an interval between the dominant component and each of the guard components.

According to a measuring method or a control method of life activity, a life object is illuminated with an electromagnetic wave including a wavelength in a designated waveband, and a characteristic in a local area of the life object is detected, or a life activity thereof is controlled. This “local area” is an area constituted by one or more cells. The “designated waveband” is defined based on any one of the following phenomena: [1] transition energy between a ground state of a vibration mode newly occurring between atoms in a constituent molecule of a cell membrane and a plurality of excited states; [2] transition energy between vibration modes occurring between specific atoms in a molecule corresponding to the activity of the life object or the change thereof; and [3] a specific chemical shift value in Nuclear Magnetic Resonance.

An example method includes receiving, by an implantable device and from an external device, an energy signal; transducing, by the implantable device, the energy signal into electrical power; outputting, by the implantable device and to the external device, a feedback signal that represents an absolute level of the electrical power transduced from the energy signal, wherein the feedback signal includes a first portion that represents a relative level of the electrical power transduced from the energy signal and a second portion that represents a reference voltage level; and delivering, by the implantable device, a level of electrical stimulation therapy proportional to the absolute level of the electrical power transduced from the energy signal.

The present disclosure provides a vital sign measuring device and method that may measure a heart rate signal of a living body in a motion state. The method comprises detecting two different signals, using an adaptive noise removal algorithm for removing noise from the two signals, and obtaining a more accurate heat rate signal after a certain operation.

A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.