An x-ray imaging system and method for reconstructing three-dimensional images of a region of interest from spatially and temporally overlapping x-rays using novel reconstruction techniques are provided. The x-ray imaging system may include a detector to generate a signal in response to x-rays incident upon the detector, wherein the signal indicates the intensity of the x-rays incident upon a pixel of the detector, a plurality of x-ray sources arranged to emit x-rays such that said x-rays pass through a region of interest (ROI) and spatially and temporally overlap at the pixel of the detector, and a processing unit to receive the signal indicating the intensity of x-rays incident upon the pixel of the detector and generate an estimate of the intensity attributable to each of the two or more x-rays overlapping at the pixel of the detector.

A method of imaging motion of an organ that changes volume in a patient including the steps of monitoring change in volume of the organ, and recording multiple in vivo images of the organ, wherein the change of organ volume between the images is constant or of some other predetermined value.

Disclosed is a method of radiography of an organ of a patient, including: first and second vertical scanning being performed synchronously, wherein a computed correction is processed on both first and second raw images, on at least part of patient scanned height, for at least overweight or obese patients, so as to reduce, between first and second corrected images, cross-scattering existing between the first and second raw images, and wherein the computed correction processing on both the first and second raw images includes: a step of making a patient specific modeling, using as patient specific data therefore at least both first and second raw images, a step of determining a patient specific representation of radiation scattering by the patient specific modeling, a step of processing the patient specific radiation scattering representation on both the first and second raw images so as to get the first and second corrected images.

Digital breast tomosynthesis represents an enhanced type of mammogram for detecting breast cancer. In this disclosure, data from digital breast tomosynthesis is reconstructed into a volumetric database with each voxel having a (x, y, z) coordinate and viewed in true 3D using geo-registered head display unit and geo-registered tools for overall enhanced diagnosis. The breast is imaged under various configurations and the internal architecture of an anatomic feature three-dimensionally analyzed. Additional dataset creation and three-dimensional imaging techniques are disclosed.

Targeting of a lesion which is performed by a stereoscopic biopsy device or the like is performed simply and highly accurately. Designation of a predetermined position in the stereoscopic image is received to acquire position information when a stereoscopic image is displayed, radiological images of radiographing directions are displayed as two-dimensional images, a mark based on the position information, which is designated in the stereoscopic image, is displayed in the two-dimensional images, designation of a predetermined position in the two-dimensional images is further received to acquire the position information after the mark is displayed.

3D image display device and method are provided. The 3D image display device divides a first 3D image into multiple depth layers, determines irregular pixels corresponding to the divided depth layers, generates second 3D images corresponding to the depth layers, respectively, using the corresponding irregular pixels, and synthesizes the generated images, thereby providing a final high-resolution 3D image.

The present teachings generally provide for a surgical navigation system for use with an x-ray imaging device. The x-ray imaging device acquires x-ray images of an anatomical structure of interest at an angular position. The surgical navigation system includes a localizer with a tracking sensor, a gravity vector sensor coupled to the tracking sensor, a tracking device configured to be coupled to the C-arm so as to be movable with the C-arm between a plurality of angular positions. The tracking device comprises a tracking element detectable by the tracking sensor. A computer processor is operatively coupled with the localizer and configured to implement an imaging routine that receives tracking data from the tracking sensor and a gravity vector from the gravity vector sensor, generating an image vector indicative of the angular position at which the x-ray image was acquired.

A system and method for enhanced navigation for use during a surgical procedure including planning a navigation path to a target using a first data set of computed tomography images previously acquired; navigating a marker placement device to the target using the navigation path; placing a plurality of markers in tissue proximate the target; acquiring a second data set of computed tomography images including the plurality of markers; planning a second navigation path to a second target using the second data set of computed tomography images; navigating a medical instrument to a second target; capturing fluoroscopic data of tissue proximate the target; and registering the fluoroscopic data to the second data set of computed tomography images based on marker position and orientation within the real-time fluoroscopic data and the second data set of computed tomography images.

A self-shielded and computer controlled system for performing non-invasive stereotactic radiosurgery and precision radiotherapy using a linear accelerator mounted within a two degree-of-freedom radiation shield coupled to a three-degree of freedom patient table is provided. The radiation shield can include an axial shield rotatable about an axial axis and an oblique shield independently rotatable about an oblique axis, thereby providing improved range of trajectories of the therapeutic and diagnostic radiation beams. Such shields can be balanced about their respective axes of rotation and about a common support structure to facilitate ease of movement. Such systems can further include an imaging system to accurately deliver radiation to the treatment target and automatically make corrections needed to maintain the anatomical target at the system isocenter. Various subsystems to automate controlled and coordinated movement of the movable shield components and operation of the treatment related subsystems to optimize performance and ensure safety are also provided.

According to some aspects, an x-ray apparatus for imaging and/or radiation therapy is provided, the x-ray apparatus comprises an electron source capable of generating electrons, at least one first target arranged to receive electrons from the electron source, the at least one first target comprising material that, in response to being irradiated by the electrons, emits broad spectrum x-ray radiation, at least one second target arranged to receive at least some of the broad spectrum x-ray radiation, the at least one second target comprising material that, in response to irradiation by broad spectrum x-ray radiation from the first target, emits monochromatic x-ray radiation, and at least one detector positioned to detect at least some of the monochromatic x-ray radiation emitted from the at least one second target. According to some aspects, a relatively low cost, relatively small footprint x-ray apparatus for generating monochromatic x-ray radiation suitable for medical/clinical purposes and appropriate for use in existing medical facilities such as hospitals and/or small clinical settings is provided.