A system and method for reconstructing locations of sensors in radiopaque images may estimate sensor locations in two groups of good radiographic images and use them to estimate candidate sensor locations in a group of bad radiographic images B1, . . . , Bn in which many sensors are indiscernible. A first iterative process pervading from the first image B1 to the last image Bn may determine a first set of candidate sensor locations, and a second iterative process pervading from the last image Bn to the first image B1 may determine a second set of candidate sensor location for each image. Location of a sensor in each image Bi may be estimated based on the pertinent first and second candidate sensor locations related, or determined for, the particular sensor in the particular image. Sensor locations still missing in the series of images are, then, estimated using the already estimated sensor locations.

Various methods and systems are provided for comparison of medical scan images during functional imaging evaluation. In one example, structural similarity between a first scan image and a second scan image of a lesion may be determined by implementing a deep learning model including plurality of neural networks trained with base structures and different perturbations of base structures, and ranking structural similarity based on a selected neural network model trained with perturbations of base structures corresponding to the structural difference between the first and second scan images.

Surface enhanced Raman scattering (SERS) nanoparticles and methods of using them for detecting reactive oxygen species are disclosed. In particular, methods of using SERS nanoparticles to detect and quantify reactive oxygen species Synthesis and monitor oxidative stress and disease-relevant changes in levels of reactive oxygen species are provided.

Apparatus, techniques and systems are described for facilitating identification of a target area during a probe-guided radio-localization surgical procedure. The described apparatus, techniques and systems can be used to implement a nuclear-uptake mode controller integrated into a probe to allow a user to instantly switch between multiple nuclear-uptake modes directly from the probe hand-piece. For example, a nuclear-uptake mode controller integrated into the probe can be used to instantly switch between a high-sensitivity nuclear-up-take mode and a high-resolution nuclear-uptake mode to effectively identify the target area in the presence of interfering nuclear signals by better matching the probe's nuclear detection parameters to a search task for that target area.

An apparatus for detecting a locating medium in tissue includes a probe, and a console. The probe includes a handle and a detector disposed on a distal end of the probe. The console is in communication and includes a display. The display has a first graphical representation and a second graphical representation. The first graphical representation is configured to depict a count real-time count based on a signal from the detector. The second graphical representation is configured to depict a target count.

The invention relates to a system for imaging an object in an x-ray imaging mode and in a gamma imaging mode. A radiation detector (1) of the system comprises a conversion unit (202) including a plurality of detector pixels (206.sub.1, . . . ,M) and generating for each detection event a detection signal indicative of an energy of the event, and a counting unit (203) including for each detector pixel (206.sub.1, . . . ,M) a plurality of comparators (209.sub.i; 1, . . . ,N) and associating each detection event to one of a plurality of predetermined energy bins based on the detection signals using the comparators (209.sub.i; 1, . . . ,N). In the x-ray imaging mode, the comparators (209.sub.i; 1, . . . ,N) of one pixel (206.sub.1, . . . ,M), and in the gamma imaging mode, the comparators (209.sub.i; 1, . . . ,N) of several pixels (206.sub.1, . . . ,M) are available for the association so that more energy bins are available in the gamma imaging mode than in the x-ray imaging mode.

Systems and methods for image reconstruction are provided. The methods may include obtaining a first image sequence of a subject and obtaining an initial input function that relates to a concentration of an agent in blood vessels of the subject with respect to time. The first image sequence may include one or more first images generated based on a first portion of scan data of the subject. The methods may further include, for each of a plurality of pixels in the one or more first images, determining at least one correction parameter associated with the pixel and determining, based on the initial input function and the at least one correction parameter, a target input function The methods may further include generating one or more target image sequences related to one or more dynamic parameters based at least in part on a plurality of target input functions.

Disclosed are devices, systems and methods for providing sterile and cost-affordable handheld surgical devices with tactile operable controls. In some aspects, a surgical device includes a surgical probe including a probe detector and a set of operable controls; an exterior shell casing including an opening at one end leading to an interior cavity structured to have a size and shape to fit the surgical probe within and position the probe detector in a first region and a handle of the surgical probe in a second region, in which the first region of the exterior shell casing is configured to be inserted into an incision of a patient's body and the second region is configured to provide a user of the surgical device utilization of the operable controls of the surgical probe through the exterior shell casing; and a cap attachable to the exterior shell casing to close the opening.

A medical image diagnostic system according to an embodiment includes processing circuitry configured to acquire first information related to an exposure dose of a subject by a radioactive agent administered to the subject, and display reference information for determining imaging conditions of X-ray CT imaging to be performed with respect to the subject on a display, based on the first information and second information related to a reference dose.

A SPECT scanner for making images of an object using gamma radiation comprises a collimator that extends along a longitudinal direction around an object space and that comprises a set of pinholes for the gamma radiation, a detection device for gamma radiation that is allowed to pass through from the object space by the pinholes, and an object carrier for bringing the object into the object space along the longitudinal direction. At least one pinhole is provided in a pinhole body that is rotatable in the collimator around an axis of rotation. Because the pinholes themselves rather than the collimator are made rotatable, the entire object space with the object therein can be advantageously scanned without having to move the object. The properties of the collimator can also easily be adjusted, even during scanning.