A method of imaging reconstruction includes providing a detector and a collimator, operating the detector to acquire a measured image of a target object from photons passing through the collimator, partitioning the collimator such that the collimator can be represented by a first matrix, providing an initial estimated image of the target object, and calculating an estimated image of the target object based on the measured image and the first matrix. The calculating of the estimated image includes an iteration using the initial estimated image as a starting point. The method also includes partitioning the collimator such that the collimator can be represented by a second matrix larger than the first matrix, and calculating a refined estimated image of the target object based on the measured image and the second matrix. The calculating of the refined estimated image includes an iteration using the estimated image as a starting point.

A multimodal system for breast imaging includes an x-ray source, and an x-ray detector configured to detect x-rays from the x-ray source after passing through a breast. The system includes an x-ray detector translation system operatively connected to the x-ray detector so as to be able to translate the x-ray detector from a first displacement from the breast to a second displacement at least one of immediately adjacent to or in contact with the breast. The system includes an x-ray image processor configured to: receive a CT data set from the x-ray detector, the CT data set being detected by the x-ray detector at the first displacement; compute a CT image of the breast; receive a mammography data set from the x-ray detector, the mammography data set being detected by the x-ray detector at the second displacement; and compute a mammography image of the breast.

Improved imaging devices and methods. A portable SPECT imaging device may co-register with imaging modalities such as ultrasound. Gamma camera panels including gamma camera sensors may be connected to a mechanical arm. A coded aperture mask may be placed in front of a gamma-ray photon sensor and used to construct a high-resolution three-dimensional map of radioisotope distributions inside a patient, which can be generated by scanning the patient from a reduced range of directions around the patient and with radiation sensors placed in close proximity to this patient. Increased imaging sensitivity and resolution is provided. The SPECT imaging device can be used to guide medical interventions, such as biopsies and ablation therapies, and can also be used to guide surgeries.

The present invention relates to an X-ray anti-scatter grid (10). The anti-scatter grid comprises a plurality of primary septa walls (20), and a plurality of secondary septa walls (30). The plurality of primary septa walls comprise an X-ray absorbing material. The plurality of primary septa walls are substantially parallel to one another. The plurality of secondary septa walls are located between adjacent pairs of walls of the plurality of primary septa walls such that each secondary septa wall is located between an adjacent pair of walls of the plurality of primary septa walls. Each secondary septa wall of the plurality of secondary septa walls is formed from a plurality of columnar structures (40) extending between the plurality of primary septa walls. The plurality of columnar structures comprise an X-ray absorbing material.

The present invention relates to a detector (10) for a dark-field and/or phase-contrast interferometric imaging system. The detector comprises a plurality of pixels (50), a plurality of first detector arrays (20), pixel a plurality of second detector arrays (30), and a processing unit (40). The plurality of pixels are arranged in a two-dimensional pattern. Each pixel comprises a first detector array and a second detector array. Each first detector array comprises a plurality of fingers (22). Each second detector array comprises a plurality of fingers (32). For each pixel the fingers of the first detector array are interleaved alternately with the fingers of the second detector array. For each pixel interaction with an incident X-ray photon can lead to charge generation in at least one finger of the first detector array of that pixel and can lead to charge generation in at least one finger of the second detector array of that pixel. For each pixel the first detector array is configured to detect a cumulative charge associated with the plurality of fingers of the first detector array and the second detector array is configured to detect a cumulative charge associated with the plurality of fingers of the second detector array. For each pixel the processing unit is configured to assign an X-ray interaction event to either the first detector array or the second detector array on the basis of the detector array that has the highest cumulative charge.

A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain contrast-enhanced images related to an examined subject and corresponding to a plurality of temporal phases. On the basis of data values of pixels in the contrast-enhanced images corresponding to the plurality of temporal phases, the processing circuitry is configured to determine which one of contrast enhancement dominance and fluid accumulation dominance corresponds to the pixels or a region including the pixels. The processing circuitry is configured to generate a display mode based on the determination.

In accordance with the invention, an X-ray amplitude analyzer grating adapted for use in an interferometric imaging system, the interferometric imaging system comprising an X-ray source and an X-ray detector with an X-ray fringe plane between the X-ray source and the X-ray detector, wherein an X-ray fringe pattern is formed at the X-ray fringe plane, wherein the X-ray amplitude analyzer grating is provided. The X-ray amplitude analyzer grating comprises a plurality of grating pixels across two dimensions of the X-ray amplitude analyzer grating, wherein each grating pixels of the plurality of grating pixels has a different pattern with respect to all adjacent grating pixels to the grating pixel so that all adjacent grating pixels do not have a same pattern as the grating pixel.

A radiation imaging apparatus includes a pixel array including, in an imaging region where a plurality of pixels is arranged in a matrix, a detection pixel group in which a plurality of detection pixels is arranged in a row direction, and a control unit configured to control imaging. A grid having a stripe structure in which a radiation transmissive layer and a radiation absorption layer that are strip-shaped and extend in a first direction are alternately arranged in a second direction is disposed and can be used in the radiation imaging apparatus. The radiation imaging apparatus further includes a determination unit configured to determine whether a mode in which the imaging using signals from the detection pixel group is controlled is executable by the control unit, based on information about an angle between the row direction and the first direction.

A detector sub-assembly for a CT system includes a detector module that includes a mount block having a top planar surface, a Y-axis planar surface that is parallel with the top planar surface, an X-axis planar surface that is orthogonal to the first Y-axis planar surface, and an aperture passing through the X-axis planar surface. The module includes a substrate having a pixelated photodiode positioned thereon, and a two-dimensional anti-scatter grid (ASG) positioned on the pixelated photodiode. The detector sub-assembly includes a support structure including a Y-axis mount surface and an X-axis mount surface, and a second aperture passing through the X-axis mount surface, a mounting screw having an outer diameter that is smaller than an inner diameter of the aperture and passing through the aperture and into the second aperture when the Y-axis planar surface is on the Y-axis mount surface.

A fixture for fabricating a detector mini-module includes a lower block having a Y-datum lower block upper surface, an X-datum lower block surface, and a Z-datum lower block surface orthogonal to both the Y-datum lower and X-datum block surface surfaces. A mount block for a detector is positionable and in contact with the X-datum lower block surface, the Y-datum lower block upper surface, and the Z-datum lower block surface. An intermediate block is positionable on the lower block having an aperture passing through an upper surface and having an X-datum intermediate block surface and a Z-datum intermediate block surface. When a mount block for the detector mini-module is positioned on the lower block, the mount block is biased having an X-axis mount block planar surface aligned with the X-datum lower block surface, and biased having a Z-axis mount block planar surface aligned with the Z-datum lower block surface.