A heat transfer fluid including 1-trifluoromethyl-1,2,2-trifluorocyclobutane (TFMCB) for high temperature heat transfer applications and environmental and safety requirements, which is non-flammable (and has no flash point below 100 F.), has low toxicity, an ODP of <0.01 and a GWP of 44, is dielectric and electrically stable.

The present disclosure relates to compositions comprising 1,1,2,2-tetrafluoroethane and at least one additional compound selected from the group consisting of 1,1-difluoroethane, 1,2-difluoroethane, 1,1,1-trifluoroethane, difluoromethane, octafluorocyclobutane, 1,1,1,2,3,4,4,4-octafluoro-2-butene, 1,1,1,2,3,3,3-heptafluoropropane, 1,1,3,3,3-pentafluoropropene, 1,1,1,2,2-pentafluoropropane, 1,2,3,3,3-pentafluoropropene, pentafluoroethane, chlorodifluoromethane, 2-chloro-1,1,1,2-tetrafluoroethane, 1-chloro-1,1,2,2-tetrafluoroethane, methyl chloride, chlorofluoromethane, 1,2-dichloro-1,1,2,2-tetrafluoroethane, 1,1-dichloro-1,2,2,2-tetrafluoroethane, 1,1-difluoroethylene, and 1,1,2-trifluoroethylene and combinations thereof. These compositions are useful as refrigerants, heat transfer compositions, thermodynamic cycle (e.g. heating or cooling cycle) working fluids, aerosol propellants, foaming agents (blowing agents), solvents, cleaning agents, carrier fluids, displacement drying agents, buffing abrasion agents, polymerization media, foaming agents for polyolefins and polyurethane, gaseous dielectrics, power cycle working fluids, extinguishing agents, and fire suppression agents in liquid or gaseous form.

The refrigerant composition includes R1150 refrigerant, R170 refrigerant, and a third refrigerant. The third refrigerant is one of R1132a refrigerant and R1270 refrigerant. A method of making a refrigerant composition for an HVACR system includes mixing an amount of R1150 refrigerant, an amount of R170 refrigerant, and an amount of the third refrigerant. A method of retrofitting an existing refrigerant composition in an HVACR system includes adding at least one of R1150 refrigerant, R170 refrigerant, and a third refrigerant to the existing refrigerant composition to obtain a retrofit refrigerant composition.