A system for assisting guiding an endovascular instrument in vascular structures of an anatomical region of interest of a patient. This system includes an imaging device for capturing three-dimensional images of parts of the body of a patient, a programmable device and a viewing unit. The imaging device captures partially superposed fluoroscopic images of the region, and the programmable device forms a first augmented image, representative of a complete panorama of bones of the region, and cooperates with the imaging device to obtain a second augmented image including a representation of the vascular structures of the region. The imaging device captures a current fluoroscopic image of a part of the region, and the programmable device registers the current fluoroscopic image with respect to the first augmented image and locates and displays, on the viewing unit, an image region corresponding to the current fluoroscopic image in the second augmented image.

Described is an injector system for implementing a split bolus injection procedure. The injector system includes a processor and a non-transitory storage medium having programming instructions stored therein that, when executed by the processor, enable the injector system to operate as a parameter generation system for use in determining parameters associated with a split bolus injection protocol via which injection of the contrast agent by the injector system is controlled. The split bolus injection protocol includes at least a loading injection and a diagnostic injection, wherein the loading injection is performed before the diagnostic injection, and wherein a pause separates the loading injection from the diagnostic injection. Also described is a method for patient imaging using a split bolus injection technique and a system having an imaging device and the injector system described above.

Various methods and systems are provided for tracking a biopsy target across one or more images. In one example, a method includes determining a position of a biopsy target in a selected image of a patient based on an image registration process with a reference image of the patient, and displaying a graphical representation of the position of the biopsy target on the selected image.

Metal complexes including a radionuclide and a compound of Formula I and Formula II are potent inhibitors of PSMA. ##STR00001##

Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon an injection of a contrast agent, processing acquired projection data of a monitoring area of a subject to measure a contrast signal of the contrast agent, estimating two or more target times of the contrast agent at the monitoring area of the subject based on the contrast signal, and carrying out a contrast scan that includes a two or more acquisitions each performed at a respective target time.

A robotic catheter procedure system includes a bedside system and a workstation. The bedside system includes an actuating mechanism configured to engage and to impart movement to a percutaneous device. The workstation includes a user interface and a control system configured to be operatively coupled to the user interface, the bedside system, and a medical imaging system. The control system is responsive to a first input and to a second input, and the user interface receives the second input from a user. The control system is configured to generate a first control signal to the medical imaging system based on the first input, and the medical imaging system captures at least one image in response to the first control signal. The control system is configured to generate a second control signal to the actuating mechanism based on the second input, and the actuating mechanism causes movement of the percutaneous device in response to the second control signal. The first input is indicative of upcoming percutaneous device movement.

A method for medical imaging using a diffusivity contrast agent is provided. The method includes obtaining the diffusivity contrast agent having specific diffusivity, wherein the diffusivity contrast agent is configured to pass a biological barrier of a subject; administering to the subject a detectable dose of the diffusivity contrast agent for at least one medical imaging modality, where the medical imaging modality includes one or more of MRI, PET, SPECT, CT, x-ray, optical imaging and ultrasound; acquiring one or more post-contrast images for a region of interest after the administration of the diffusivity contrast agent, wherein said post-contrast images include changes in diffusivity of the region of interest compared to one or more images acquired without said diffusivity contrast agent; and characterizing a transport of the diffusivity contrast agent in the region of interest based on the changes in diffusivity of the region of interest.

Methods are provided for dynamically visualizing information in image data of an object of interest of a patient, which include an offline phase and an online phase. In the offline phase, first image data of the object of interest acquired with a contrast agent is obtained with an interventional device is present in the first image data. The first image data is used to generate a plurality of roadmaps of the object of interest. A plurality of reference locations of the device in the first image data is determined, wherein the plurality of reference locations correspond to the plurality of roadmaps. In the online phase, live image data of the object of interest acquired without a contrast agent is obtained with the device present in the live image data, and a roadmap is selected from the plurality of roadmaps. A location of the device in the live image data is determined. The reference location of the device corresponding to the selected roadmap and the location of the device in the live image data is used to transform the selected roadmap to generate a dynamic roadmap of the object of interest. A visual representation of the dynamic roadmap is overlaid on the live image data for display. In embodiments, the first image data of the offline phase covers different of phases of the cardiac cycle of the patient, and the plurality of roadmaps generated in the offline phase covers the different phases of the patient's cardiac cycle. Related systems and program storage devices are also described and claimed.

At least one vascular tree supplying at least a part of the hollow organ in the computed tomography dataset is segmented, and a tree structure up to an order possible based on the blood vessel segmentation result is determined from a blood vessel segmentation result. Perfusion information for each edge in the tree structure is assigned as at least one of the computed tomography data assigned to the blood vessel segment or at least one value derived therefrom. Adjacent hollow organ segments of the hollow organ are defined based on supply by adjacent blood vessels in the tree structure, and the tree structure and the perfusion information are analyzed to determine hemodynamic information to assign to hollow organ segments. At least a part of the hemodynamic information in at least one of the computed tomography dataset or a visualization dataset derived therefrom is then visualized.

Imaging systems and methods for imaging assisted interventional procedure that receive images of a region of interest, that automatically detect in the images a contrast agent puff as it courses through the region of interest, and that generate a display including a video replay loop of contrast enhanced images based on the automatic detection of the contrast agent puff.