A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry collects pieces of past image data in a plurality of time phases that contain at least a part of a coronary artery of a heart and new image data in one time phase that contains at least a part of the coronary artery and has been acquired after acquisition of the pieces of past image data. The processing circuitry performs registration processing between the pieces of collected past image data and registration processing between any one of the pieces of past image data and the new image data. The processing circuitry generates pieces of synthesized image data corresponding to the time phases of the pieces of past image data other than the past image data on which the registration processing with the new image data has been executed by reflecting a shape of the new image data based on results of the registration processing. The processing circuitry derives a fluid parameter related to the coronary artery by executing fluid analysis using the pieces of synthesized image data.

The disclosure relates to compositions comprising isolated mitochondria or combined mitochondrial agents, and methods of treating disorders using such compositions.

An X-ray CT apparatus according to an embodiment includes processing circuitry. The processing circuitry collects pieces of image data in a plurality of time phases that contain at least a part of a coronary artery of a heart. The processing circuitry acquires image indexes regarding the pieces of image data. The processing circuitry extracts a set of image data from combinations of pieces of image data having a larger time interval than a predetermined time interval, of the pieces of image data, based on the image indexes in the respective pieces of image data. The processing circuitry performs fluid analysis regarding the coronary artery based on the extracted set of image data to obtain a fluid parameter regarding the coronary artery.

An electrophysiology catheter is disclosed having a balloon with a membrane. Electrodes may be disposed on the membrane. Each electrode may include a radiopaque marker. The markers may have different forms, e.g., alphanumeric or polygonal, to facilitate visualization of the electrodes using a bi-stable image and allow for selection of the appropriate electrodes to be energized during ablation of tissue. The inventive subject matter allows for proper orientation of electrodes on the balloon under a two-dimensional imaging system. This allows the operator or physician to determine if certain electrodes are adjacent or contiguous to the posterior surface of the left atrium and ablate such posterior surface for shorter duration or at a lower power to create an effective transmural lesion on the posterior wall of the left atrium while reducing the chances of damaging the adjacent anatomical structures.

In one embodiment, a medical image diagnostic apparatus includes a memory circuit; a display; and processing circuitry configured to acquire medical images of an object at respective time phases, detect respective positions of a treatment device in the medical images, acquire biological information from the medical images, compute biological indexes indicating degree of a treatment effect for the respective time phases based on the biological information, cause the memory circuit to store the biological indexes and the respective positions of the treatment device in the medical images such that each biological index is associated with a position of the treatment device in a medical image, from which the biological information corresponding to the each biological index is acquired, for the respective time phases, and cause the display to display each position of the treatment device and a biological index associated with the each position of the treatment device.

Apparatus and methods are described including, using a computer processor, automatically identifying whether a given pixel within an image corresponds to a portion of an object. A set of concentric circles that are disposed around the pixel are sampled, and a first function is applied to each of the circles such that the circles are defined by a first set of rotationally invariant descriptors. A second function is applied to the set of circles to generate a second set of descriptors, each of which represents a difference between respective pairs of the circles. A third function is applied such that the second set of descriptors becomes rotationally invariant. The processor identifies whether the given pixel corresponds to the portion of the object, based upon the first and second sets of rotationally invariant descriptors. Other applications are also described.

Systems are provided for generating data representing electromagnetic states of a heart for medical, scientific, research, and/or engineering purposes. The systems generate the data based on source configurations such as dimensions of, and scar or fibrosis or pro-arrhythmic substrate location within, a heart and a computational model of the electromagnetic output of the heart. The systems may dynamically generate the source configurations to provide representative source configurations that may be found in a population. For each source configuration of the electromagnetic source, the systems run a simulation of the functioning of the heart to generate modeled electromagnetic output (e.g., an electromagnetic mesh for each simulation step with a voltage at each point of the electromagnetic mesh) for that source configuration. The systems may generate a cardiogram for each source configuration from the modeled electromagnetic output of that source configuration for use in predicting the source location of an arrhythmia.

The invention relates to a method for identifying an ischaemic region (O.sub.n) of an organ based on anatomical data, wherein the ischaemic region (O.sub.n) is 0.2 to 1 part of the stenosed region at risk (O.sub.z) downstream of the threshold point (P.sub.prog). The size of the ischaemic region (O.sub.n) is proportional to the difference between the indicative value at the threshold point (P.sub.prog) and at the measuring point (P.sub.pom) in the artery. The invention also relates to a system for identifying organ ischaemia, a computer program for identifying organ ischaemia and a computer program product.

A noninvasive system for imaging, planning, and treating cardiac arrhythmia in a subject includes a noninvasive means for imaging a heart and identifying an arrhythmia including an array of body surface electrodes for noninvasively measuring electrical potentials at a plurality of locations to identify the arrhythmia, and a geometry determining device for noninvasively obtaining a heart-torso geometry. An imaging processor computes heart electrical activity data and generates an image of the heart from the electrical potentials and the heart-torso geometry. A treatment planning system for developing a noninvasive treatment plan for the arrhythmia is configured to import an arrhythmia target defined relative to the image of the heart, and register the imported arrhythmia target to a primary planning dataset. A noninvasive means for treating the arrhythmia includes implementing the noninvasive treatment plan developed by the treatment planning system.

According to an embodiment, there is provided that processing circuitry configured to determine a first radiation timing at which a subject is irradiated with an X-ray, based on information on motion of an object in X-ray image data, the information on motion being calculated by the X-ray image data, the X-ray image data being associated with an electrocardiographic waveform of the subject, and repeatedly irradiate the subject with an X-ray at the first radiation timing per cycle of the electrocardiographic waveform of the subject.