Provided herein are methods and systems for making patient-specific therapy recommendations of a lipid-lowering therapy for patients with known or suspected cardiovascular disease, such as atherosclerosis.

The invention relates to a system and a method for determining a characteristic of a blood vessel portion, which comprises blood including a contrast agent exhibiting resonant absorption of x-ray photons at a specific energy. The system comprises a tunable monochromatic x-ray source (21) emitting x-ray radiation, an x-ray detector device (22) for detecting the x-ray radiation after it has travelled through the blood vessel portion. A control unit (26) varies a tuning of the x-ray source (21) to vary the energy of the x-ray radiation emitted by the x-ray source (21), and an evaluation unit (27) determines a tuning of the x-ray source (21) at which nuclear resonant absorption of the x-ray radiation incident onto the blood vessel portion occurs and estimates the characteristic on the basis of the determined tuning. The characteristic may particularly be the blood velocity in the blood vessel portion.

A method is for actuating a medical imaging device for generating a second three-dimensional image dataset including a target region in a region of interest of a patient with a functional impairment. The method includes providing a first three-dimensional image dataset including the region of interest of the patient; identifying the target region based on the first three-dimensional image dataset, a partial region of the region of interest with the functional impairment being determined; determining an imaging parameter for generating the second three-dimensional image dataset based on the identified target region; and actuating the medical imaging device based on the imaging parameter for the generation of the second three-dimensional image dataset.

Disclosed is a medical imaging system, including a processor circuit configured for communication with an x-ray imaging device movable relative to a patient and an intravascular catheter or guidewire sized and shaped for positioning within a blood vessel of the patient, wherein the processor circuit is configured to receive a first angiographic image of a first length of the vessel and a second angiographic image of a second length of the vessel, wherein the first image is obtained at a first position and the second angiographic image is obtained at a second position. The processor is further configured to generate a roadmap image of a combined length of the blood vessel by combining the first image and the second image, and to receive intravascular data associated with the blood vessel, and to co-register the intravascular data to corresponding locations in the roadmap image; and output the roadmap image and a graphical representation of the intravascular data at the corresponding locations in the roadmap image.

The present invention provides scanning mechanisms for imaging probes using for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and/or optical coherence tomography. The imaging probes include adjustable rotational drive mechanism for imparting rotational motion to an imaging assembly containing either optical or ultrasound transducers which emit energy into the surrounding area. The imaging assembly includes a scanning mechanism having including a movable member configured to deliver the energy beam along a path out of said elongate hollow shaft at a variable angle with respect to said longitudinal axis to give forward and side viewing capability of the imaging assembly. The movable member is mounted in such a way that the variable angle is a function of the angular velocity of the imaging assembly.

A medical information processing apparatus includes processing circuitry. The processing circuitry is configured to acquire medical image data representing a blood vessel of a subject, extract a blood vessel shape from the medical image data, determine degree of meandering in each of regions from the extracted blood vessel shape, specify a deformed region in which the degree of meandering changes due to insertion of a device into the blood vessel on the basis of the degree of meandering, and output the deformed region in the blood vessel.

Methods and systems are provided for adaptive scan control. In one embodiment, a method includes processing acquired projection data of a monitoring area of a subject to measure a first contrast signal of a contrast agent administered to the subject via a first injection, initializing a contrast scan of the subject according to a fallback scan prescription, determining when each of a plurality of zones of the contrast scan are estimated to occur based on the contrast signal, generating a personalized scan prescription for the contrast scan based on when each of the plurality of zones are estimated to occur, and performing the contrast scan according to the personalized scan prescription after a second injection of the contrast agent.

A system and method for generating a parametric map of a subject's brain includes receiving non-contrast computed tomography (NCCT) imaging data and receiving computed tomography perfusion (CTP) data. The method further includes creating a baseline image by utilizing the NCCT data and generating a parametric map using the CTP data and the baseline image.

The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, perform computational fluid dynamics analysis, facilitate assessment of risk of heart disease and coronary artery disease, enhance drug development, determine a CAD risk factor goal, provide atherosclerosis and vascular morphology characterization, and determine indication of myocardial risk, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

A computer-implemented method for autonomous segmentation of contrast-filled coronary artery vessels, the method comprising the following steps: receiving (101) an x-ray angiography scan representing a maximum intensity projection of a region of anatomy that includes the coronary vessels on the imaging plane; preprocessing (102) the scan to output a preprocessed scan; and performing autonomous coronary vessel segmentation (103) by means of a trained convolutional neural network (CNN) that is trained to process the preprocessed scan data to output a mask denoting the coronary vessels.