Systems and methods are provided for performing model-based cochlear implant programming (MOCIP) on a living subject with a cochlear implant (CI) to determine stimulation settings of a patient-customized electro-neural interface (ENI) model. The method includes: localizing an electrode array of the CI and intracochlear structures of the living subject to determine patient-specific electrode positions of the CI and a patient-specific anatomy shape; generating a CI electric field model based on the patient-specific electrodes positions of the CI and the patient-specific anatomy shape; and establishing an auditory nerve fiber (ANF) bundle model using the CI electric field model, and estimating neural health of the living subject using the ANF bundle model applications of the same.

A system for providing neuronal stimulation signals configured to elicit sensory percepts in the cortex of an individual, comprising means for obtaining spatial information relating to the actual or planned position of a neuronal stimulation means relative to afferent axon(s) targeting sensory neuron(s) in the cortex of the individual and means for determining a neuronal stimulation signal to be applied to the afferent axon(s) via the neuronal stimulation means based at least in part on the obtained spatial information.

A system for communicating conceptual information to an individual, comprising means for selecting a neuronal stimulation signal to be applied to afferent axon(s) targeting sensory neuron(s) in the cortex of the individual, wherein the neuronal stimulation signal corresponds to the conceptual information to be communicated and means for transmitting the neuronal stimulation signal to the neuronal stimulation means of the individual.

The present invention relates to a method and a device for detecting a nerve, the method comprising the steps of: acquiring a learning image including a plurality of splices arranged in a coronal plane direction; generating learning data in which a nerve and mental tubercle and/or a mandibular angle, serving as a reference for detecting the nerve, are set in the learning image, and learning the learning data so as to generate a learning model; inputting a target image into the learning model; and detecting a nerve from the target image on the basis of the learning data, and application through other embodiments is possible.

A method for localization and identification of a structure in a projection image with a system having a known system geometry, includes acquiring a preoperative computer-tomography or CT image of a structure, preprocessing the CT-image to a volume image, acquiring an intraoperative two dimensional or 2D X-ray image, preprocessing the 2D X-ray image to a fix image, estimating an approximate pose of the structure, calculating a digitally reconstructed radiograph or DRR using the volume image, the estimated pose and the system geometry, and calculating a correlation between the generated DRR and the fix image, with a correlation value representing matching between the generated DRR and the fix image. The method significantly decreases the number of wrong-level surgeries and is independent of the surgeon's ability to localize and/or identify a target level in a body.

Various embodiments of medical detector systems as well as their methods of operation are disclosed. In one embodiment, one or more detectors are coupled to wearable structures for detecting at least a first tracer within a body portion. In another embodiment, one or more detectors are coupled to a wearable structure, where the detector corresponds to a CMOS chip that directly detects a first radioactive tracer.

It has been discovered that even mild changes in cerebrospinal fluid (CSF) pressure or intracranial pressure (ICP) can be detected immediately as evidenced by distortions in the ONS surface structure. Further, the changes in the ONS persist after the CSF pressure has returned to normal. The stability of ONS distortions provides a means of detecting transient changes in brain pressure even when the use of the diagnostic ultrasound is delayed. One embodiment provides systems and methods for detecting or diagnosing brain injury by detecting distortions or deformations of the ONS, preferably using ultrasound.

A bioelectric current estimation method includes acquiring position information of a nerve in a measurement target region of a subject for which magnetic data is measured with a magnetic sensor, the position information of the nerve being acquired based on a nerve image included in a morphological image of the measurement target region; acquiring a positional relationship between a position of the nerve and a position of the magnetic sensor, based on the acquired position information of the nerve and position information of the magnetic sensor when the magnetic sensor is positioned to face the measurement target region; and estimating a neural activity current, which is generated in association with neural activity of the subject, based on the acquired positional relationship and the magnetic data of the measurement target region measured by the magnetic sensor.

Aspects described herein disclose devices, systems, and methods for use in contexts such as minimally invasive surgery (MIS). A device is provided herein having a proximal portion and a distal portion, and an ultrasound transducer may be disposed within the distal portion and configured to scan tissue and identify certain portions of a patent's anatomy during the scanning process. The results of the detection may be presented to an operator of the device aurally and/or visually, such as in a 3-D volumetric image. By scanning the tissue, identifying the anatomy, and presenting the results to an operator, unnecessary damage to elements of the patients anatomy may be avoided or lessened. In some aspects, multiple transducers may be positioned on the device to increase the scanning range and/or scanning accuracy of the device. The device may provide an inner channel for the passage of surgical tools while scanning tissue.

It has been discovered that even mild changes in cerebrospinal fluid (CSF) pressure or intracranial pressure (ICP) can be detected immediately as evidenced by distortions in the ONS surface structure. Further, the changes in the ONS persist after the CSF pressure has returned to normal. The stability of ONS distortions provides a method of detecting transient changes in brain pressure even when the use of the diagnostic ultrasound is delayed. One embodiment provides systems and methods for detecting or diagnosing brain injury by detecting distortions or deformations of the ONS, preferably using ultrasound.

Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission. The labeled pain factors allow spatial differentiation in the imaging sufficient to specify the location of the pain so as to drive therapeutic decisions and techniques in order to treat the pain. Pain factors labeled and imaged in this manner may include one or more of nerve factors, blood vessel factors, cellular factors, and inflammation factors. Labeled markers may include for example radioactive materials (e.g. tritiated or iodinated molecules) or other materials such as metal (e.g. gold) nanoparticles. Intermediary binding materials may be used, such as for example bi-specific antibodies. Therapeutic components of the system and method include for example localized energy delivery or ablation treatments, or local drug or other chemical delivery. Locations containing pain factor selectively bound by targeted agents are selectively treated with directed energy into a region containing the targeted agent bound to the pain factor.