Methods, computer program products, and systems are presented. The methods include, for instance: providing a cognitive tour guide service to a group of participants for a tour with an initial route planned by participants registration information and environment information along the initial route. During the tour, real time sensory data on the participants and environment are collected by a cognitive agent accompanying the group to lead the tour are relayed to a cognitive tour guide engine, and real time multi-objective optimization is modeled and performed. The participants are regrouped responsive to their respective objectives of the tour as represented by respective levels of interest in certain stage of the tour as well as circumstances of the environment. Respective subgroups are formed from the participants per respective objectives, and respective new routes are selected from a set of optimal solutions for each subgroup. During the tour, the cognitive tour guide engine iteratively optimizes routes responsive to incoming real time sensory data, objectives of the tour, and participant feedback.

Methods, computer program products, and systems are presented. The methods include, for instance: providing a cognitive tour guide service to a group of participants for a tour with an initial route planned by participants registration information and environment information along the initial route. During the tour, real time sensory data on the participants and environment are collected by a cognitive agent accompanying the group to lead the tour are relayed to a cognitive tour guide engine, and real time multi-objective optimization is modeled and performed. The participants are regrouped responsive to their respective objectives of the tour as represented by respective levels of interest in certain stage of the tour as well as circumstances of the environment. Respective subgroups are formed from the participants per respective objectives, and respective new routes are selected from a set of optimal solutions for each subgroup. During the tour, the cognitive tour guide engine iteratively optimizes routes responsive to incoming real time sensory data, objectives of the tour, and participant feedback.

This document discusses, among other things, apparatus, systems, or methods to efficiently collect heart sound data, including detecting first heart sound information of a heart of a patient using a heart sound sensor in a first, low-power operational mode, and detecting second heart sound information of the heart using the heart sound sensor in a separate second, high-power operational mode. The operational mode of the heart sound sensor can be controlled using physiologic information from the patient, including heart sound information, information about a heart rate of the patient, or other physiologic information from the patient that indicates worsening heart failure.

This document discusses, among other things, apparatus, systems, or methods to efficiently collect heart sound data, including detecting first heart sound information of a heart of a patient using a heart sound sensor in a first, low-power operational mode, and detecting second heart sound information of the heart using the heart sound sensor in a separate second, high-power operational mode. The operational mode of the heart sound sensor can be controlled using physiologic information from the patient, including heart sound information, information about a heart rate of the patient, or other physiologic information from the patient that indicates worsening heart failure.

Embodiments of the present disclosure relate to systems and methods for determining a subject's blood pressure using one or more implantable medical devices (IMDs). In an embodiment, a medical system comprises: at least one implantable medical device configured to sense signals associated with heart sounds of a subject and a processing unit communicatively coupled to the at least one implantable medical device. The processing unit is configured to: receive heart sound signals corresponding to the signals associated with the heart sounds; and calculate a surrogate of the subject's blood pressure using at least one heart sound signal of the received heart sound signals.

Embodiments of the present disclosure relate to systems and methods for determining a subject's blood pressure using one or more implantable medical devices (IMDs). In an embodiment, a medical system comprises: at least one implantable medical device configured to sense signals associated with heart sounds of a subject and a processing unit communicatively coupled to the at least one implantable medical device. The processing unit is configured to: receive heart sound signals corresponding to the signals associated with the heart sounds; and calculate a surrogate of the subject's blood pressure using at least one heart sound signal of the received heart sound signals.

Systems and methods for monitoring patients with a chronic disease are described. A patient management system may sense physiological signals from a patient using one or more implantable or other ambulatory sensors, and generate from the physiological signals a chronobiological rhythm indicator (CRI) such as indicating a circadian rhythm. A reference CRI associated with a prior hospital admission event of the patient may be provided to the patient management system, which compares the CRI to the reference CRI and generates a readmission risk score indicating the patient's risk of subsequent hospital readmission due to a worsened condition of the chronic disease. The readmission risk score may be provided to a user or a process, or used to initiate or adjust a therapy delivered to the patient.

A bio-signal quality assessment apparatus may include: a bio-signal obtainer configured to obtain a bio-signal; and a processor configured to extract periodic signals from the obtained bio-signal, and determine a signal quality index based on at least one of similarity between the extracted periodic signals and signal variability of the obtained bio-signal.

There is provided a device for measuring fatigue of a person, the device comprising a frame configured to be worn within the mouth of the person, a microphone mounted within the frame and configured to measure sound data, and a cavity located within the frame and adjacent to the microphone, wherein the cavity does not communicate with the environment surrounding the frame. There is also provided a computer-implemented method for determining a fatigue metric representing a level of physical fatigue of a person

There is provided a device for measuring fatigue of a person, the device comprising a frame configured to be worn within the mouth of the person, a microphone mounted within the frame and configured to measure sound data, and a cavity located within the frame and adjacent to the microphone, wherein the cavity does not communicate with the environment surrounding the frame. There is also provided a computer-implemented method for determining a fatigue metric representing a level of physical fatigue of a person