An ultrasound system acquires and displays contrast-enhanced ultrasound images as a bolus of contrast agent washes into and out of a region of interest in the body. During the wash-in, wash-out cycle the operation of the ultrasound system is changed to optimize system performance for different portions of the contrast cycle. The ultrasound transmission, receive signal processing, and image processing are among the operations of the ultrasound system which may be changed. The changes in system operation are invoked automatically at predetermined times or event occurrence during the wash-in, wash-out cycle.

An ultrasound imager provides for LAA closure guidance. Using ultrasound imaging allows for modeling over time (e.g., throughout a heart cycle). An anatomy model of the LAA over time is used to create a biomechanical model personalized to the patient. The personalized models and a model of one or more closure devices are used to select a closure device for the patient appropriate for the entire heart cycle and to guide placement of the selected closure device during an implantation.

A system for monitoring hemodynamics of a subject is disclosed. The system comprises: a signal generating system configured for providing at least an output electric signal and transmitting the output signal to an organ of the subject. The system also comprises a demodulation system configured for receiving an input electrical signal sensed from the organ responsively to the output electric signal, and for modulating the input signal using the output signal to provide an in-phase component and a quadrature component of the input signal. The system also comprises a processing system configured for monitoring the hemodynamics based on the in-phase and the quadrature components.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

The present invention relates to systems, methods and algorithms for determination of heart pump function and their use in livings subject are described. The invention further relates to complementary parts of such systems that work best in combination. Medical catheters, sheaths and shafts are disclosed that carry an arrangement of integrated digital sensor systems-on-chip (SoC) in the portion thereof residing inside the body. These devices combine at their portion that resides inside the body, the complete chain of signal transduction, signal analog-to-digital conversion and digital signal transmission, and allow to acquire single and multiple physical entities in a single setup. In specific instances the devices integrate wireless data transfer functionality, and in specific instances they integrate wireless energy harvesting for battery-free functionality. The present invention further describes complementary monitor systems that are suited for reception, processing and analysis of data acquired by such catheters/sheaths/shafts to yield a robust assessment of cardiac performance. Moreover, the present invention relates to innovations which render such systems applicable to patients with and without cardiac assist devices.

Systems and methods are described herein for predictive heart valve simulation. The systems and methods described herein can include segmenting anatomical region of a heart of a patient from image data characterizing the heart of the patient. Anatomical model data that can include three-dimensional shapes of the anatomical regions of the heart can be generated based on the image data. The anatomical model data can be used to generate anatomical model data. The analytical model data can include a three-dimensional mesh of the anatomical regions of the heart. A deformed analytical model that can be indicative of a deformed position of the anatomical regions of the heart and a deformed position of the surgical object can be generated based on the analytical model data.

A stand-alone continuous cardiac Doppler or acoustic pulse monitoring patch provides visual and auditory signals that a pulse or heartbeat is detected or not detected in a human subject. The invention is a small patch with a peel-away adhesive surface that is applied to the skin of the subject, preferably near a large artery. For the Doppler monitor, the patch includes a pad formed of a conductive medium to enhance transmission and reception of ultrasonic waves. For the acoustic monitor, the pad has a sound focusing portion that permits entry of sounds and focuses the sounds toward a microphone, and the pad also has a sound insulating portion surround the sound focusing portion. The patch includes an integral power source. The Doppler patch has transmitters and receivers to send and detect reflected ultrasonic waves and a transducer to convert the reflected waves into an electrical signal. The acoustic patch has a microphone to detect the sound of a heartbeat and a transducer to convert the sound energy into an electrical signal. A processor analyzes the Doppler wave signals or the acoustic signals. A light indicates the presence and strength of a pulse detected from the Doppler wave signals or a heartbeat detected by the microphone. A speaker and a vibrator may also to indicate the presence and strength of a pulse or a heartbeat. The Doppler effect of waves reflecting from blood pumped from a heart is used to detect a pulse in the subject. The presence of a pulse or heartbeat is analyzed by the processor to determine the frequency and strength of blood flow or beating of the heart. The processor causes the light, speaker or vibrator to blink, beep or vibrate at a rate to indicate the frequency of rhythmic blood flow or heartbeat.

A method for estimating a ventricular volume is provided and includes: obtaining a left ventricular mask image corresponding to a heart ultrasound image, where the left ventricular mask image is a binary image; finding 3 reference point pixels in the left ventricular mask image, where each of the reference point pixels has a first value, each of the reference point pixels is surrounded by N surrounding pixels, and the surrounding pixels of each of the reference point pixels include N1 first surrounding pixels with the first value and N2 second surrounding pixels with a second value; estimating a left ventricular volume corresponding to the heart ultrasound image based on the reference point pixels.

Various methods and systems for displaying cine loops during a periodic imaging session are disclosed. In one example, a method includes acquiring, with an ultrasound probe, a first set of images of an imaging subject during a first imaging period, displaying the first set of images as a first cine loop at a first display area of a display, acquiring, with the ultrasound probe, a second set of images of the imaging subject during a second imaging period different than the first imaging period, and displaying the second set of images as a second cine loop at a second display area of the display, different than the first area, while maintaining display of the first cine loop at the first display area.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.