The present disclosure relates to a method for determining a relative position between arrays of a flexible array device. The flexible array device according to an embodiment includes a plurality of arrays arranged at a predetermined interval in a deformable substrate, and the method includes measuring the first capacitance between adjacent arrays, measuring the second capacitance between the adjacent arrays after deformation of the substrate, and determining a relative position between the adjacent arrays based on the first capacitance measurement value and the second capacitance measurement value. According to an embodiment, the relative position between the arrays may be determined by measuring the capacitance between the adjacent arrays of the plurality of arrays arranged in the deformable substrate and measuring a change in capacitance caused by the deformation (contraction, relaxation, bending) of the substrate.

Described herein is an implantable device configured to detect impedance characteristic of a tissue. In certain exemplary devices, the implantable device comprises (a) an ultrasonic transducer configured to emit an ultrasonic backscatter encoding information relating to an impedance characteristic of a tissue based on a modulated current flowing through the ultrasonic transducer; (b) an integrated circuit comprising (i) a variable frequency power supply electrically connected to a first electrode and a second electrode; (ii) a signal detector configured to detect an impedance, voltage, or current in a circuit comprising the variable frequency power supply, the first electrode, the second electrode, and the tissue; and (iii) a modulation circuit configured to modulate the current flowing through the ultrasonic transducer based on the detected impedance, voltage, or current; and the first electrode and the second electrode configured to be implanted into the tissue in electrical connection with each other through the tissue. Further described are systems including one or more implantable devices and an interrogator for operating the implantable device, methods of measuring impedance characteristic of a tissue in a subject, and methods of monitoring or characterizing a tissue in a subject.

The present disclosure provides a method for identifying sites for administering cells in cell therapy for central nervous system damage in a subject, comprising the steps of: A) acquiring image data on at least part of the subject's brain, with an imaging device; B) obtaining information on the subject's brain, with a computer device in communication with the imaging device; C) using the image data and data pertaining to the subject's brain acquired by the computer device to depict motor fibers; D) identifying damaged locations where motor fibers have suffered damage, with the computer device, identifying a portion where motor fiber run-data is lower than another portion and identifying the lower portion as being motor fibers that have suffered damage; E) using the computer device to select, as sites of administration, safe regions near the damaged locations; and F) outputting, as graphic display, the selected sites of administration.

An ultrasound transducer assembly is connectable to an ultrasound system and comprises one or more ultrasound transducer elements supported by a cap. The ultrasound transducer elements are operable to direct ultrasound energy toward brain tissue of a subject and/or to receive echo ultrasound energy when the ultrasound transducer assembly is mounted on the head of the subject. Some embodiments include a fillable jacket coupled to the inner surface of the cap and in acoustic contact with the one or more transducer elements.

During acquisition of an ultrasound image feed, ultrasound control data frames are acquired that may be interspersed amongst the ultrasound data frames. The control data frames may use consistent reference scan parameters, irrespective of the scanner settings, and may not need to be converted to image frames. The control data frames can be passed to an artificial intelligence model, which predicts the suitable settings for scanning the anatomy that is being scanned. The artificial intelligence model can be trained with a dataset containing different classes of ultrasound control data frames for different settings, where substantially all the ultrasound control data frames in the dataset are consistently acquired using the reference scan parameters.

An ultrasound transducer array is incorporated in a light-weight, conformable, and wearable patch that may be used to deliver, monitor, and control localized transcranial focused ultrasound (tFUS). The patch may include full-duplex transmit-receive circuitry that may be used for continuous monitoring of transcranial focused ultrasound (tFUS) application. The circuitry may include a circulator. The ultrasound transducer array may be coupled to an aperture interface having irregularly sized or shaped channel conductors to provide a coarse aperture for the array. The coarse aperture may be designed using a method that provides a reduced channel count.

Arrangements described herein relate to systems, apparatuses, and methods for categorizing a waveform that includes processing a signal containing ultrasound data about the waveform, identifying one or more morphological variables of the waveform based on the ultrasound data, identifying one or more categories that correspond to a range of combinations of the morphological variables, and categorizing the waveform as belonging to one of the one or more categories. In some arrangements, the method may further include visualizing the waveforms, determining a probability that the waveform belongs to each of the one or more categories, and/or displaying the probability that the waveform falls into each of the one or more categories. Morphological variables may include quantifying absolute peak onset, number/prominence of auxiliary peaks, and systolic canopy length.

Example implementations include a system with a first communication channel operatively coupled with a cranial sensor system and operable to transmit a cranial sensor output obtained from the cranial sensor system to one or more remote devices, and a second communication channel operatively coupled with the cranial sensor system and operable to transmit a diagnostic output associated with the cranial sensor output to the remote device(s).

An interventional medical device is provided that incorporates a forward-directed ultrasound or optical coherence tomography imaging system that is replaceable depending on how close the device is to the target site for a given medical procedure, the device and system integrated into a single minimally invasive device comprising a first probe housing, needle guide assembly and sheath, a sleeve lock for closing a normally open needle channel of a needle guide of the first distal assembly and a second probe and cable housing assembly locked to the first distal probe housing, needle guide assembly and sheath by a locking tab. The probe and cable housing assembly may comprise a linear phased ultrasound array and an accelerometer for orienting an image produced by the device with the gravitational field of the earth. The medical device can be in the form of an image guided catheter or probe, used in a body orifice, externally on skin tissue or subcutaneously. The device comprises a replaceable and reusable ultrasound imaging assembly (and or OCT assembly) and replaceable interventional devices such as a removable introducer needle, hollow biopsy needle, syringe or other medical instrument. The imaging system may comprise one or more small ultrasound or OCT imaging systems that can be replaceably integrated into the device by replacing the reusable second probe and cable housing assembly.

A medical headgear includes an ultrasound transducer and a headgear. The ultrasound transducer is configured to generate a low intensity ultrasound. The headgear supports the ultrasound transducer. The headgear includes a rear portion case including a slide guide configured to support an occipital and a support pad configured to support a crown. The headgear further includes a front portion case connected to the rear portion case to be slidably movable in one direction. The front portion case includes two temporal support pads configured to support both temporal portions.