Systems and methods for super-resolution ultrasound imaging of microvessels in a subject are described. Ultrasound data are acquired from a region-of-interest in a subject who has been administered a microbubble contrast agent. The ultrasound data are acquired while the microbubbles are moving through, or otherwise present in, the region-of-interest. The region-of-interest may include, for instance, microvessels or other microvascuiature in the subject. By isolating, localizing, tracking, and accumulating the microbubbles in the ultrasound data, super-resolution images of the microvessels can be generated.

An apparatus and a method for contrast-enhanced ultrasound (CEUS) including use of a fluid dynamics model for the analysis of dynamic contrast-enhanced ultrasound (DCEUS).

Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.

The present invention provides novel compositions and methods for targeted delivery of therapeutics. In particular, the invention provides compositions comprising a plurality of carriers, such as microbubbles, wherein at least one active agent is associated or co-administered with the plurality of carriers for delivery to a target site, e.g., an organ, a tissue, or a tumor site, in a subject. The present invention also provides methods for treating a disease or condition, methods of targeted delivery of an active agent, e.g., to a target site, in a subject, using the carriers based compositions of the invention. The present invention further provides apparatus, devices and methods for preparing the compositions of the present invention.

Markers (e.g., treatment site markers, biopsy site markers) are composed of a non-metallic material having a composition and/or other features or characteristics such that the markers will generate twinkling artifacts when imaged with ultrasound. In this way, the composition of the markers enables their detection and localization using ultrasound. The markers are generally composed of non-metallic materials that enhance the twinkling artifact.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

The present invention comprises methods, compositions, devices and systems for determining the status of, or treating, a body structure or conduit. An embodiment of the invention comprises a fluid pressure control device for pressure control of fluid introduced into a body structure or conduit.

A dual frequency transducer array includes one or more low frequency transducer arrays and a high frequency transducer array. Unfocused ultrasound such as plane waves are transmitted by the one or more low frequency transducer arrays in a number of different directions into an imaging region of the high frequency transducer array. High frequency echo signals produced by excited contrast agent in the imaging region are received by the high frequency transducer array to produce a contrast agent image. In another embodiment, the high frequency transducer produces unfocused ultrasound to excite the contrast agent in the imaging region and the low frequency transducer(s) receives low frequency echo signals from the excited contrast agent. A tissue image is created from echo signals received by the high or low frequency transducer. Echo data from the tissue image and the contrast agent image are combined to produce a combined tissue/contrast agent image.

A device and a control program of a device. According to an embodiment, the device includes a display and a processor. The processor is configured to display first and second B-mode images created based on an echo signal of an ultrasonic pulse acquired from a subject on the display. The first and second B-mode images displayed on the display are moving images, and the first and second B-mode images of each frame forming the moving image are created based on the same echo signal. The second B-mode image is displayed smaller than the first B-mode image on the display.

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for contrast enhanced ultrasound quantification imaging are provided. One of the methods includes: obtaining, for each location in a region of interest, a time-dependent ultrasound signal with respect to the region of interest for a time period; determining, for the each location, a processed time-dependent ultrasound signal based at least on the obtained time-dependent ultrasound signal, wherein: the processed time-dependent ultrasound signal maps one or more portions of the obtained time-dependent ultrasound signal that each locally increase over a threshold, and the processed time-dependent ultrasound signal flattens one or more portions of the obtained time-dependent ultrasound signal that do not each locally increase over the threshold; and generating a sequence of images of the region of interest based at least on the processed time-dependent ultrasound signal of the each location, wherein the generated sequence of images displays signal variations of the processed time-dependent ultrasound signal in one or more structures in the region of interest to render the one or more structures.