The disclosure herein relates to systems, methods, and devices for medical image analysis, diagnosis, risk stratification, decision making and/or disease tracking. In some embodiments, the systems, devices, and methods described herein are configured to analyze non-invasive medical images of a subject to automatically and/or dynamically identify one or more features, such as plaque and vessels, and/or derive one or more quantified plaque parameters, such as radiodensity, radiodensity composition, volume, radiodensity heterogeneity, geometry, location, and/or the like. In some embodiments, the systems, devices, and methods described herein are further configured to generate one or more assessments of plaque-based diseases from raw medical images using one or more of the identified features and/or quantified parameters.

A Doppler phantom includes a first reservoir, a second reservoir, a fluid line coupling the first and second reservoirs, a pressure line coupling the first and second reservoirs, and a tissue mimicking material surrounding at least the fluid line. The phantom can be positioned in first and second positions, where the first reservoir defines an elevated reservoir and the second reservoir defines a lower reservoir in the first position, where the second reservoir defines the elevated reservoir and the first reservoir defines the lower reservoir in the second position. The fluid line provides a path for fluid to travel from the elevated reservoir to the lower reservoir via gravity in either of the first or second positions, and the pressure line provides a path for gas to transfer from the lower reservoir to the elevated reservoir while the fluid travels in either of the first or second positions.

The present invention relates to an ultrasound-based system for localizing a medical device within the field of view of an ultrasound imaging probe. A localization system is provided that includes at least three ultrasound emitters that are arranged on a frame; and a position triangulation unit. The frame is adapted for attachment to an ultrasound imaging probe. The position triangulation unit determines a spatial position of the ultrasound detector relative to the at least three ultrasound emitters based on signals received from an ultrasound detector that is attached to the medical device. The frame includes a detachable reference volume comprising a background volume and an inclusion or void. When the detachable reference volume is attached to the frame and the frame is attached to the ultrasound imaging probe the inclusion or void provides a corresponding image feature within the field of view of the ultrasound imaging probe for use in calibrating the field of view of the ultrasound imaging probe with the coordinate system of the localization system.

An ultrasound device captures skeleton density information. This ultrasound device includes at least two transmitters 100, 102 having a distance of L1 between them for transmitting ultrasound signals into the skeleton, at least two receivers 104 having a distance of L2 between them for receiving ultrasound signals from the skeleton, as the calibrated known distance L is at least one of distances L1 and L2. The ultrasound device also includes a processing unit 101 for calculating a ultrasound velocity in the skeleton for forming skeleton density information on the basis of the ultrasound signals received by the receivers 104, 106 by dividing known distance by an average of a travel time difference for a ultrasound signal between the receivers 104, 106 receiving the ultrasound signal from the first transmitter 100 and the second transmitter 102.

The quality of ping-based ultrasound imaging is dependent on the accuracy of information describing the precise acoustic position of transmitting and receiving transducer elements. Improving the quality of transducer element position data can substantially improve the quality of ping-based ultrasound images, particularly those obtained using a multiple aperture ultrasound imaging probe, i.e., a probe with a total aperture greater than any anticipated maximum coherent aperture width. Various systems and methods for calibrating element position data for a probe are described.

In viscoelastic imaging with ultrasound, the shear wave speed or other viscoelastic parameter is measured by tracking at the ARFI focal or other high-intensity location relative to the ARFI transmission. Rather than tracking the shear wave, the tissue response to ARFI is measured. A profile of displacements over time or a spectrum thereof is measured at the location. By finding a scale of the profile resulting in sufficient correlation with a calibration profile, the shear wave speed or other viscoelastic parameter may be estimated.

A method for real-time correction of tissue compression for tracked ultrasound includes acquiring an ultrasound image of tissues of interest with an ultrasound probe having a probe surface, where the ultrasound probe is tracked to provide a position and an orientation of the probe surface of the ultrasound probe for the acquired ultrasound image; acquiring intraoperative measurements of the undeformed tissue surface; constructing a generic grid representation of tissues for use with a mathematical model of tissue biomechanics, where the generic grid representation is pre-aligned to the acquired ultrasound image by performing a calibration to the ultrasound probe; determining boundary conditions to the mathematical model represented by the generic grid representation; solving the mathematical model for 3D displacements in the generic grid representation of the tissues; and performing correction of tissue compression by using the reversed and interpolated 3D displacement field on the acquired ultrasound image.

A calibration system for a pulsed phase-lock loop ultrasound measurement system comprising an apparatus having a compartment for holding a pressure sensitive liquid. The compartment has an opening by which a flow of the pressure sensitive liquid may be controlled. A sensor arranged relative to the compartment to receive ultrasonic signals that reflect off one or more inner surfaces of the compartment. The system includes a processing device for receiving an integrated error signal output by the sensor based on pressure changes of the pressure sensitive liquid responsive to a change in flow of pressure sensitive liquid between the source and the compartment.

Systems and methods are provided for employing informational models trained using the Autoprogressive Algorithm to learn the mechanical behavior of biological materials using a sparse sampling of force and displacement measurements. The constitutive matrix normally used to solve the inverse problem is replaced with ANNs.

The present disclosure relates generally to the field of medical procedures performed using ultrasound imaging for guidance. In particular, the systems and methods of the present disclosure include anatomical models simulating body organs that may be used to train clinicians, students or other medical professionals to access such organs with medical tools in performing interventional procedures using ultrasound guidance.