An electronic system for determining a time of the temperature nadir of a female human during the menstrual cycle comprises a wearable device (1) that includes a first sensor system (104), configured to determine a temperature of the female human, and a second sensor system (101, 102, 103), configured to determine one or more further physiological parameters of the female human. The electronic system further comprises a processor (13, 30, 40), configured to determine a detected starting point of the fertility phase of the female human, using the one or more further physiological parameters of the female human. The processor (13, 30, 40) is further configured to detect the temperature nadir as a temporary decrease in the temperature, using the detected starting point of the fertility phase of the female human. The time of the temperature nadir is used as an indicator of the time of ovulation and peak oestrogen level.

Devices, systems, and methods for detecting estrus in subjects are provided. Devices include a housing configured for intravaginal/intrauterine deployment and retention and a sensor disposed in or on the housing, and are configured to use condition information sensed by the sensor to determine an estrus condition of the subject. Methods include deploying a device in the subject, sensing the condition information, and determining an estrus condition using the condition information. Systems include a device configured to communicate with a base station and/or with other implanted devices, which are located within a reception radius thereof, regarding the determined estrus condition.

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

Devices, systems and related methods for direct and in-vivo monitoring and stimulation of the endometrial cavity include a plurality of sensing modalities incorporated on a set of flexible conductive filaments that allows its insertion in an endometrial cavity through the vagina. The flexible set of conductive filaments is in direct contact with the endometrium to maximize recording sensitivity and acquire direct readings, which correspond to the functionality of the endometrium and/or electrically stimulate endometrial peristalsis in a controlled manner. The same electrodes can be used for a controlled stimulation to strengthen weakened muscle tissue before and after medical and surgical interventions on the uterus, to reset to normal contractility. The methods and systems disclosed herein can be used to improve the chances of success for artificial insemination, including in-vitro fertilization, embryo transfer, and intrauterine insemination, diagnostic tests, and may further improve the overall understanding of endometrial functionality.

The invention relates to a computer implemented method, a computer system (1), and a computer program product for determining a menopausal state, and particularly relates to such a method, system (1) and computer program product that employs sensors measuring data and processing the measured data by means of a self-learning classification model (43). Disclosed is a computer implemented method for providing a model for determining a menopausal state, comprising the steps: determining a set of measurable body conditions from a group of body conditions of a human body, the body conditions being indicative of a menopausal state of a human body (5), determining a set of training objects, the training objects being humans being capable of adopting a menopausal state and having a known state concerning their menopausal state as menopausal state information, measuring the measurable body conditions of the set of measurable body conditions of each of the training objects for a predetermined amount of time to provide measured body condition information for each of the training objects, preprocessing the measured body condition information to provide preprocessed body condition information, providing a computer implemented classification model (43) adapted to classify a menopausal state, inputting the preprocessed body condition information of a training object as training input information to the classification model (43), inputting the menopausal state information of the test object as training classification information to the classification model (43), adapting the classification model (43) according to the training input information and training classification information.

An electronic system for determining a fertility phase of a female human comprises a wearable device (1) that includes a first sensor system (101), configured to determine heart rate and heart rate variability of the female human, and a second sensor system (102), configured to determine acceleration of the female human. The electronic system further comprises a processor (13, 30), configured to detect during menstrual cycles sleep phases with resting pulse, using the heart rate variability and the acceleration, to determine a change in the resting pulse during a menstrual cycle using the heart rate, and to determine the fertility phase using a time of the change in the resting pulse. The processor for determining the fertility phase is implemented in the wearable device (1), in a mobile communication device (4), and/or in a cloud-based computer system (3).

A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. Second and third uterine evaluation device include: a flexible and rod-shaped main body for insertion into a uterine cavity; and four or two impedance electrodes arranged with a predetermined interval therebetween in an insertion direction of the main body and brought into contact with an endometrium of the uterine cavity to measure a uterine endometrial impedance generated between the endometrium and each of the electrodes.

A sensor unit for characterizing a biological liquid includes a plurality of conductive threads incorporated into a textile and a microcontroller electrically connected to the threads. The microcontroller is configured to apply a test signal to a first conductive thread and receive feedback signals from a second conductive thread. The feedback signals indicate that a biological liquid is electrically connecting the conductive threads. By comparing the feedback signals received at two or more time points, the microcontroller can compute a drying metric for the biological liquid. Additional features include monitoring the change in voltage of the feedback signal over time and estimating the volume of the liquid. The sensor unit may be incorporated into a wearable garment or included in a fertility monitoring system. In the fertility monitoring system, a computing device receives and compares the feedback signals to determine the drying metric for the biological liquid.

An electronic system for detecting events related to a pregnancy of a female human, such as ovulation, conception, and miscarriage, comprises a wearable device (1) with a sensor system (100) worn in contact with the skin for measuring one or more physiological parameters. A processor (13, 30, 40) is configured to receive a user entry indicating a time of actual menses, and to determine time windows, for analyzing physiological parameters of the female human, using the time of actual menses. The processor is further configured to detect the pregnancy related events by comparing the physiological parameters, determined and recorded for a first time window, with those determined and recorded for a second time window, to indicate the pregnancy related events when defined detection criteria are met, and to use the user input for pregnancy related events to optimize the detection of these events with machine learning trained algorithms.