A method for collecting tissue includes a body fluid removal step in which a body fluid inside a pancreatic cyst is moved to an outside of the pancreatic cyst, an injecting step in which a liquid different from the body fluid is injected into the pancreatic cyst, a collecting step in which the liquid is collected from the pancreatic cyst, and a separating step in which tissue of an inner wall of the pancreatic cyst, which is contained in the liquid collected from the pancreatic cyst, is separated from the liquid.

This special gut microbe and chemical substance sampling technology, utilizing swallowable capsules, is for purpose of determining roles gut contents play in some 52 of most costly, in lives and dollars, of diseases with their known origin in the human gut. Gut microbes and substances are collected, analyzed, medicinal substances and objects deployed, and special provisions for attracting, capturing and preserving certain strains of microbes, and means for perturbing the gut environment and immune system are all intended to research, discover, and ultimately find both the causes and cures for the most devastating human diseases, and in the process, create gut microbiome profiles.

Ingestible devices with a relatively large payload volume or sample volume, as well as related components, systems and methods, are disclosed.

In alternative embodiments, the invention provides compositions such as devices, pills, beads, capsules, products of manufacture, particles, microparticles, nanoparticles, gels, liquid gels, liquid gel capsules, capsules, tablets, geltabs, liquids, sprays, emulsions, suspensions, pastes or yogurts, for the detection and isolation of biomarkers, nucleic acids, proteins or peptides, proteoglycans, lipids, fats, sugars or polysaccharides in the gastrointestinal tract for e.g., detecting the presence of particular exogenous or endogenous nucleic acids, e.g., DNA or RNA, or proteins, in the gastrointestinal tract, for example, to diagnose the presence of an infectious or exogenous agent such as a virus, a fungus, a parasite, a bacteria, intestinal helminths and protozoan parasites, and the like, or a biomarker such as a cancer-causing or cancer-predisposing allele, e.g., mutations of the KRAS2 oncogene in pancreatic cancer. In alternative embodiments, compositions of the invention comprise magnetic particles such as a magnetically-responsive microparticle or nanoparticle; a superparamagnetic bead or polystyrene bead; a superparamagnetic fine particle; a ferrimagnetic particle; or, a magnetic microsphere, nanosphere, microbead or nanobeads. In alternative embodiments, the invention provides methods for detecting, retrieving, capturing or isolating a sample of a nucleic acid, or an anionic, cationic or hydrophobic protein or peptide, a mucin, a phosphoprotein, a proteoglycan or a polysaccharide, in vivo.

The present invention provides a device that can move inside a biological conduit such as an intestinal tract for sampling the content therein, and a process thereof. While moving along the intestinal tract, the device can continuously collect the content in the intestinal tract. One or more convoy belts having an adsorbent layer are configured to continuously absorb and preserve the collected intestinal content. The belt loaded with the sample may be used to establish a chemical, biochemical and microbiological spectrum along the length of the intestinal tract.

The present invention relates to a sampling device 100. The sampling device 100 comprises a separate compartment 110 that is ejected creating an increased space or volume for a sample to be stored The sampling device 100 of the present invention is suitable for collecting a sample in an aquaculture environment, enclosed system or in the gastrointestinal tract of a human or an animal. The invention also relates to a method of orally administering the device to an animal and recovering the device 100 and/or separate compartment 110 to carry out analysis on the collected sample for diagnosing the health of the gastrointestinal tract and determining nutrient absorption and digestibility.

The present invention relates to a sampling device 100. The sampling device 100 comprises a separate compartment 110 that is ejected creating an increased space or volume for a sample to be stored. The sampling device 100 of the present invention is suitable for collecting a sample in an aquaculture environment, enclosed system or in the gastrointestinal tract of a human or an animal. The invention also relates to a method of orally administering the device 100 to an animal and recovering the device 100 and/or separate compartment 110 to carry out analysis on the collected sample for diagnosing the health of the gastrointestinal tract and determining nutrient absorption and digestibility.

The present invention relates to a sampling device 100. The sampling device 100 comprises a separate compartment 110 that is ejected creating an increased space or volume for a sample to be stored. The sampling device 100 of the present invention is suitable for collecting a sample in an aquaculture environment, enclosed system or in the gastrointestinal tract of a human or an animal. The invention also relates to a method of orally administering the device 100 to an animal and recovering the device 100 and/or separate compartment 110 to carry out analysis on the collected sample for diagnosing the health of the gastrointestinal tract and determining nutrient absorption and digestibility.

An apparatus comprising a string for insertion into the oesophagus of a patient, the string comprising proximal end and a distal end, wherein the string forms a structure at the distal end thereof to assist in the insertion of the string into the patient.

The present disclosure relates to gastrointestinal (Gl) tract microbiome detection and manipulation devices, systems, and methods. The determination of antimicrobial susceptibility of a micro-organism within the gastrointestinal tract involves identifying an antimicrobial agent that inhibits the growth of the micro-organism has been disclosed, which has been obtained from a sample having been removed from an ingestible device that retrieved the sample from the Gl tract of the subject. A test to identify the micro-organism can be included. Treatment methods related to small intestinal bacterial overgrowth (SIBO), a SIBO-related condition, or symptomology suggestive of SIBO in a subject in need thereof, involving orally administering an effective amount of a pharmaceutical formulation comprising an antimicrobial agent to the subject are also disclosed.