Device for sampling tear fluid that comprises: an extraction element (202) adapted to be applied on the eye to draw tear fluid therefrom, comprising at least one tube (209) and a distal portion (201) with at least one opening (207), a collection vessel (203), connected to said tube (209), suction means (210) adapted to continuously draw tear fluid from the eye to the collection vessel (203), through the extraction element (202) for a period higher than 10 minutes once the extraction element (202) is in place.

An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.

Devices and methods for microbiome sampling and evaluation are disclosed. Devices including a capture substrate having first and second regions suitable for first and second analytic methods, respectively, are disclosed. Methods for collecting the microbiome sample with such devices are disclosed. Methods of evaluating the microbiome sample collected with such devices are disclosed. Kits including the devices for sampling and evaluating microbiome samples are also disclosed.

We disclose a medical toilet that comprises one or more medical devices and a control for the metrics they collect. The medical devices may be used to collect metrics relevant to a user's health status. The medical toilet further comprises a conduit through which volatile organic compounds travel from the toilet bowl to the environment outside the toilet. An animal trained to identify the scent of bodily waste collected from a user that is afflicted with a disease perceives the scent of the user's bodily waste traveling through the conduit and performs a defined act upon perceiving the disease scent. The metric collected by the medical device(s) may be used to diagnose the same disease as that which the animal is trained to identify. The diagnosis provided by the animal by way of the conduit acts as a control for the metric collected by the medical device.

The present invention relates to a device for the sampling of the eye surface, to the uses thereof in research and basic diagnostics in the veterinary, agro-feeding and medical field, in particular Ophthalmology. The object of the present invention is to provide a device and a method for the sampling and analysis of the outer layers of the ocular surface, by impression cytology, solving the disadvantages of the devices of known art.

There is provided a contact lens for detecting changes in a property of ocular fluid. The contact lens comprises a lens part comprising an indicator material, wherein the volume of the indicator material is variable in dependence on a property of ocular fluid. The contact lens further comprises output means disposed on the lens part, wherein the output means is configured to provide an output which is variable in dependence on the volume of the indicator material.

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.

The objective of the present invention is to provide a liquid sample collector capable of collecting a trace amount of a specimen such as a tear safely and in an adequate amount. This trace amount liquid sample collector is characterized in that: the liquid sample collector is provided with a main body and a first absorbent body; the main body has at least one open end portion; the main body includes a hydrophobic material having elasticity; the first absorbent body is disposed at least partially inside the main body; the first absorbent body includes a water-absorbent material; and the first absorbent body is disposed in such a way as to be capable of coming into contact with the outside by way of the at least one open end portion of the main body.

A microneedle includes a base and a tip distal from the base, the microneedle being formed with an anisotropic porous composition including a plurality of channels extending in a substantially uniform direction through the microneedle from a base surface towards an outer surface defined by the tip, and the plurality of channels being adapted to enable flow of a fluid therein.

A system for measuring the flow properties of a tear duct, to ascertain its flow resistance, includes a syringe communicating with a cannula to supply liquid to a punctum of an eye, the cannula having a tip to seal to the punctum. A motor is arranged to actuate the syringe. A pressure sensor monitors the pressure of the liquid supplied to the punctum. A monitoring circuit provides an indication of the flow resistance. A feedback circuit controls the motor in accordance with the measured pressure, to maintain a preset liquid pressure, or to ensure that the liquid pressure does not exceed a preset threshold. The system may prevent flow through the other punctum of the eye. If the flow rate of the liquid supplied to the punctum is also monitored, the monitoring circuit is arranged to determine the flow resistance from the pressure and the flow rate.