The present invention relates to a device and method for easy collection, dilution, mixing and dispensing of a liquid specimen in a self-contained system. The present invention can be used in combination with numerous testing means for performing chemical, biochemical or biomedical qualitative or quantitative assays in the field of both clinical and hygiene testing.

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.

An electronic device and method are disclosed herein. The electronic device includes a sensor, and a processor. The processor may implement the method, including acquiring, by the sensor, first biometric information of a user, determining alcohol information for determining a presence of of alcohol in the user from the first biometric information, determining second biometric information of the user related to the alcohol information, and generating health information to be displayed the user or transmitted to another electronic device based on the second biometric information.

A system for measuring the flow properties of a tear duct, to ascertain its flow resistance, includes a syringe communicating with a cannula to supply liquid to a punctum of an eye, the cannula having a tip to seal to the punctum. A motor is arranged to actuate the syringe. A pressure sensor monitors the pressure of the liquid supplied to the punctum. A monitoring circuit provides an indication of the flow resistance. A feedback circuit controls the motor in accordance with the measured pressure, to maintain a preset liquid pressure, or to ensure that the liquid pressure does not exceed a preset threshold. The system may prevent flow through the other punctum of the eye. If the flow rate of the liquid supplied to the punctum is also monitored, the monitoring circuit is arranged to determine the flow resistance from the pressure and the flow rate.

A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Devices and methods for microbiome sampling and evaluation are disclosed. Devices including a capture substrate having first and second regions suitable for first and second analytic methods, respectively, are disclosed. Methods for collecting the microbiome sample with such devices are disclosed. Methods of evaluating the microbiome sample collected with such devices are disclosed. Kits including the devices for sampling and evaluating microbiome samples are also disclosed.

Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.

A microtube is used to obtain a meibum sample from an intraductal space within a meibomian gland while avoiding contamination of the sample due to contact with the lid margin. The microtube can also be used as a gland marker providing a reference marker for subsequent visualization of one or more adjacent glands, as well as a stent for a meibomian gland having lining being repopulated with cells or replaced.

An embodiment of the present disclosure provides a liquid collector that collects liquid, the liquid collector including: a flow passage member including a flow passage that connects one end and other end of the flow passage member; a contact member that is disposed at the one end of the flow passage member, that includes an elastic material, and that is configured to come into contact with a target from which liquid is to be collected; and a container that receives the liquid discharged from the flow passage at the other end of the flow passage member.

A device comprising a syringe comprising a plunger and a barrel having a longitudinal axis and a sample collection volume. The device further comprises a needle hub including an attachment device for connection with the syringe, and a syringe support connected to the needle hub. A needle is connected to the needle hub, the needle having a lumen. An internal needle is at least partially positioned within the lumen of the needle. The device further includes a motor that rotationally moves the internal needle within the needle. The needle has a first opening formed in a side of the needle, and the internal needle has a second opening formed in a side of the internal needle; and wherein material is allowed to enter when the second opening is aligned with the first opening, and wherein the material is cut when the second opening rotates past the first opening.