Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.

Disclosed herein is a sampling face mask for harvesting substances exhaled from the nose of its user, in which the risk of cross-contamination of the exhaled substances by its surrounding environment or by the process of handling the sampling mask with hand(s) or additional tools is reduced to a minimal. The sampling mask includes a mask body having a front side substantially conforms to the shape of the nose of the subject, a bottom, and one or more clamping blocks disposed on the bottom; a removable cartridge removably coupled to the mask body comprising a cartridge body having a chamber for housing the substances exhaled from the nose of the subject, and a door disposed above the chamber for opening or closing the chamber; and a driving means operably coupled to the mask body, the cartridge body, and the door for driving the door to move laterally or vertically with respective to the cartridge body; wherein, the one or more clamping blocks of the mask body can hold the door in place thereby keeping the door from closing and the chamber being disposed substantially underneath the nose and stayed open; and when the one or more clamping blocks does not hold the door in place, the door is driven close via the driving means thereby closing the chamber and allowing the removable cartridge to be separated from the mask body.

A breath component measurement apparatus includes a breath residence case. The breath residence case includes a container in the shape of a rectangular parallelepiped, an intake pipe in the shape of a circular tube which is provided at the center of a front face of the container, a pump which is formed over the whole right side surface of the container, a sensor storage unit in the shape of a circular tube which is provided at the center of a bottom surface of the container, a gas sensor which has the shape of a circular column and is stored in the sensor storage unit, a disk-shaped piezoelectric element which is supported by a groove in a slot, the slot that is formed on a left side surface of the container and has the groove supporting the piezoelectric element, and an exhaust port.

An example breath collection and sampling device disclosed herein comprises a cartridge housing having a breath capture module, and a rotary valve operatively coupling a mouthpiece with the breath capture module. The rotary valve can have an open position where breath of a user can pass through the rotary valve, across capture sites of the breath capture module, and into a vacuum port, and a closed position for sealing the breath capture module from fluid passing through the rotary valve, while allowing the breath capture module to be exposed to a reagent for subsequent analysis of contents within the captured breath.

A method of detecting hypoxia. Detecting hypoxia includes detecting, in exhaled breath, at least one indicator for hypoxia. The at least one indicator is selected from the group consisting of pentanal, 2-pentanone, 2-hexanone, 2-heptanone, 2-cyclopenten-1-one, and 4-butyrolactone.

The technology relates to devices and methods thereof for the detection of one or more biomarkers from a user's exhaled breath. In one embodiment, the present invention provides a device comprising a metered dose inhaler, and a sensor that detects one or more biomarkers comprising HFA, CO.sub.2, and NO. In another embodiment, the device detects HFA, CO.sub.2 and NO simultaneously by photoacoustic spectroscopy. In another embodiment, the device may be used as part of an overall treatment regimen for asthma or COPD.

A saliva sensing device for detecting oral health and/or overall health includes a chemically treated test strip biomarker targeted to identify bacteria in the saliva. A breathalyzer for detecting bacteria in the mouth of a user includes a housing, a sensor, and an analyzer. The sensor is coupled to the housing and extends outwardly therefrom for placing in the mouth of user and for collecting a saliva sample. The analyzer is for testing saliva that contacts the sensor.

The present invention relates to a device for the collection of breath and/or air and the processing and analysis of analytes contained therein. More particularly, the present invention relates to a method of collecting exhaled breath and/or air and processing and analyzing one or more analytes contained therein.

In devices that determine levels of substance use, a substance level in a test sample provided to the testing device by a test subject is determined. A sequence of images are captured to include a portion of the face of the test subject providing the test sample and a display of the testing device. A value indicative of the substance level detected within the test sample is determined. A validity indicator indicating validity of the value indicative of the substance level is determined. A current location is determined. The value indicative of the substance level, the validity indicator, and the current location are sent to a remote server.

An exhaled breath condensate (EBC) collection device comprising two adjacent parts foldable together and apart from each other, a condensation zone to condense exhaled breath from a subject, the condensation zone being a third part provided between the two adjacent parts and connectable to cooling means arranged in each of the two parts being in cooling relationship with the condensation zone. There is also provided a method for detecting antigens or antibodies to the antigens, the method comprising collecting EBC from a subject using the EBC collection device, performing immunochromatographic testing (ICT) of the collected exhaled breath condensate, and interpreting the immunochromatographic testing results as follows: if the immunochromatographic testing results are positive, the antigens or antibodies to the antigens are detected, or if the immunochromatographic testing results are negative, the antigens or antibodies to the antigens are not detected.