An endoscope system for delivering a fluid to a patient and retrieving for diagnostic purposes from the patient a specimen. The system includes an endoscope, a fluid container containing a fluid, and a first specimen container for receiving a specimen. The endoscope system has a first user selectable state and a second user selectable state, where the endoscope system in the first user selectable state is configured to automatically deliver the fluid from the fluid container to the patient and in the second user selectable state is configured to automatically retrieve a specimen from the patient and provide the specimen to the first specimen container.

A biopsy device includes a body, an axial tube, a needle assembly, and a tissue sample holder. The body includes a proximal end. The axial tube extends proximally from the proximal end of the body. The axial tube includes at least one aperture. The needle assembly extends distally from the body and includes a needle and a cutter. The cutter is movable relative to the needle. The tissue sample holder is configured to removably couple to a proximal end of the body such that the axial tube is disposed within the tissue sample holder. At least a portion of the tissue sample holder is rotatable relative to the body such that the tissue sample holder is configured to rotate about the axial tube. The tissue sample holder is in fluid communication with the axial tube through the at least one aperture.

A biopsy device, comprising a flexible coaxial structure, comprising an obturator within a sheath, the obturator being adapted to be displaced with respect to the sheath along the coaxial axis by a force applied at a proximal end; a disruptor, at a distal end of the obturator, adapted to disrupt a tissue surface to free cells therefrom, having a first position covered within the sheath and a second position freely extending beyond the sheath; an element, having a fixed position on the sheath, configured to limit a depth of insertion of the sheath into a cervix.

An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

A device and method for treating disease involves inserting a scope into a patient's body, the scope having a light source, a camera and a cartridge connected thereto. The cartridge has two chambers separated by membrane, a first one of the chambers containing a virus, and a second one of the chambers being connected to a plurality of microneedles configured for extending into the patient's tissue upon insertion of the scope. Cells from the patient are removed via suction from the microneedles and are deposited in the second chambers. The membrane is then broken to mix the virus with the cells to infect the cells, and the infected cells are then transported back into the patient to treat the disease.

Microgrippers adapted to capture, manipulate, and contain single cells in both in vitro and in vivo cell applications are disclosed. The energy required to actuate these microgrippers is derived from the release of residual stress and does not require any wires, tethers, or batteries. Because the microgrippers are made from biocompatible and biosorbable materials, they do not accumulate in tissue. Accordingly, they can be used for in vivo applications, such as for gripping single cells in tissue biopsies.

A biopsy device includes a body, a needle, a cutter, a tissue sample holder, and a sample stopping assembly. The needle extends distally from the body. The cutter is longitudinally translatable relative to the needle and defines a cutter lumen. The tissue sample holder is coupled proximally relative to the body. The cutter lumen of the cutter defines at least a portion of a fluid conduit extending between a distal end of the cutter and the tissue sample holder. The sample stopping assembly includes a rotatable strainer that is configured to selectively arrest movement of a tissue sample within the fluid conduit between the cutter and the tissue sample holder.

A biopsy device comprises a body, a needle, a cutter, and a tissue sample holder. The tissue sample holder comprises an outer cup and a cap. A tray retains severed tissue samples from a biopsy procedure. In some versions, the tray is selectively detachable from the cap in a one-handed operation by the user. The tray may be ejected into a sample container, such as a formalin cup. The cap may include a threaded portion that is configured to engage a complementary threaded portion of a sample container to seal the sample container once the tissue samples have been transferred to the sample container from the tissue sample holder of the biopsy device. One or more ports may be provided in the cap to manage excess fluid within the outer cup of the tissue sample holder, and/or to provide integrated access for a marker delivery device.

A single-insertion, multiple sampling biopsy device for insertion into a host includes an outer cutting cannula that has an inner lumen, a cutting distal end, and a proximal sample receiving port. The device includes a stylet extending at least partially within the inner lumen of the outer cutting cannula and along a longitudinal axis of the outer cutting cannula. A sheath extends at least partially within the inner lumen of the outer cutting cannula. A stylet tip is attached to a stylet rail. Each of the sheath and the stylet rail extends along the longitudinal axis. The stylet tip extends in the distal direction beyond the distal end of the outer cutting cannula. A drive unit is configured to translate each of the cutting cannula, the sheath, and the stylet relative to the stylet tip in proximal and distal directions. The stylet rail remains stationary relative to the drive unit.

A biopsy device for accessing and collecting multiple tissue specimens includes a probe component and a drive component. The probe component includes a probe housing that fits within a housing cover, an elongated distal shaft with a tubular section proximal to a penetrating distal tip, an elongated tissue cutting member, and a first probe gear. The tubular section having an inner lumen, an open tissue receiving aperture, and a proximal extremity configured to be operatively connected to the drive component. The elongated distal shaft secured to the probe housing. The elongated tissue cutting member is slidably disposed within the tubular section. The elongated tissue cutting member having at least one tissue cutting edge and a cutting member inner lumen extending therein. The drive component has a first driver motor and a first driving gear configured to drive the first probe gear in order to orient the open tissue receiving aperture.