A device comprises a cannula having a first end, a second end, and a channel between the first end and the second end; an imaging probe couplable to the first end of the cannula, where the imaging probe includes: a transducer, and a reflective surface; and a biopsy device coupled to the cannula, where the biopsy device is configured to collect a tissue sample from an organ of a patient.

An illustrative method in accordance with the disclosure includes introducing a visualization scope having a proximal end and a distal end into a patient's uterus by way of the vagina and cervix, advancing the distal end of the visualization scope into one of the fallopian tubes from the uterus, and advancing the distal end of the visualization scope out of said fallopian tube into an abdominal cavity of the patient.

A method of using a biological sampling device to obtain a biological sample. The device comprises a sheath, an applicator, a collector, and a handle. The method includes inserting a first applicator end into an organism with the device being in a pre-sampling configuration; transitioning the device from the pre-sampling configuration to a sampling configuration; with the device in the sampling configuration, via the handle, moving the collector against biological material within the organism to collect the biological material; transitioning the device from the sampling configuration to a post-sampling configuration; and with the device in the post-sampling configuration, withdrawing the device from within the organism.

Apparatuses and methods for performing a procedure on a uterine cavity of a patient are disclosed. The methods can include visualizing the uterine cavity, biopsying a tissue with a biopsy device, and ejecting fluid from the biopsying device into the uterine cavity. The apparatuses can have a sealable acorn tip, a handle, a repositioning clip, a distal indicia, a proximal indicia, and a fluid reservoir. The biopsying device can be configured to biopsy and eject fluid under the control of a single hand of a user of the device.

A gynecological cervical or vaginal sample removal instrument has, at the cranial end, a plurality of brushes that are fixed to a wire assembly extending in the axial direction. The brushes are made of at least 600 plastic filaments with a diameter between 350 μm and 900 μm and an axial line density of at least 600 filaments over a maximum axial extension of 3 cm.

A falloposcope is described, and a method of screening a patient for fallopian tube and/or ovarian cancer with the falloposcope. The falloposcope can perform optical imaging, including fluorescence imaging and/or optical coherence tomography (OCT), and optionally include a channel for a sampling wire, within a diameter of about 0.7 millimeter. The method includes inserting the falloposcope through a lumen of vagina, cervix, uterus, and fallopian tube so a tip of the falloposcope is in proximity to a first fallopian tube or ovary of the patient; providing fluorescence stimulus wavelength through an illumination fiber of the falloposcope while imaging light at fluorescence emission wavelength through a coherent fiber bundle to form fluorescence emissions images; and determining suspect tissue. Then the sampling wire is used to collect cells from the suspect tissue for karyotype and other analysis.

A method of analyzing vaginal fluid includes collecting vaginal fluid in a vaginal fluid collecting system and transporting the collected vaginal fluid to a location for analysis. The analysis can be stored in and retrieved from a secure cloud storage data base.

The present invention comprises methods and devices for collection of fluids, including cells and cellular materials, from the uterus. A device of the present invention comprises a central tubing member to which, at least, a flexible tubing member and an absorbable member are connected at least at one point. The absorbable member is connected to at least one portion of the central tubing member and to at least one portion of the flexible tubing member. The devices of the present invention are useful in methods of collection of uterine fluids, including blood, cells and cellular material.

A tissue removal device includes a housing, an outer tube having a distal portion configured for transcervical insertion into a uterus, an inner tube slidably disposed within the outer tube lumen, a vacuum generation chamber disposed within the housing, a movable piston slidably disposed in the vacuum generation chamber, a collection chamber, a manual actuator moveably coupled to the housing and operatively coupled to the piston, and proximal and distal one-way valves. The outer tube has an outer tube lumen, a tissue in-take opening proximate a distal end thereof, and a proximal end coupled to the housing. The inner tube has an inner tube lumen extending from an open inner tube distal end to an open inner tube proximal end, the open inner tube distal end comprising a cutting edge configured to sever intrauterine tissue extending through the tissue in-take opening in the outer tube.

A device comprises a cannula having a first end, a second end, and a channel between the first end and the second end; an imaging probe couplable to the first end of the cannula, where the imaging probe includes: a transducer, and a reflective surface; and a biopsy device coupled to the cannula, where the biopsy device is configured to collect a tissue sample from an organ of a patient.