Methods provide for the concurrent evaluation, detection and treatment of actual or potential medical conditions at a site of a body, and are particularly directed to medical procedures and concurrent treatment of areas of the body that are difficult to visualize; and a kit providing apparatus for carrying out evaluation, detection and real-time treatment of the site of a body for actual or potential medical conditions is disclosed.

A method of using a biological sampling device to obtain a biological sample. The device comprises a sheath, an applicator, a collector, and a handle. The method includes inserting a first applicator end into an organism with the device being in a pre-sampling configuration; transitioning the device from the pre-sampling configuration to a sampling configuration; with the device in the sampling configuration, via the handle, moving the collector against biological material within the organism to collect the biological material; transitioning the device from the sampling configuration to a post-sampling configuration; and with the device in the post-sampling configuration, withdrawing the device from within the organism.

A method of analyzing vaginal fluid includes collecting vaginal fluid in a vaginal fluid collecting system and transporting the collected vaginal fluid to a location for analysis. The analysis can be stored in and retrieved from a secure cloud storage data base.

A device for self-collection of a cervical sample includes an enclosure, a sample-collecting head, and a slider and a knob on the enclosure. The enclosure can be gripped by a user in one hand and inserted into the user's vaginal canal. The enclosure has an opening at one end, and a sample-collecting head can be advanced and retracted through the opening. The slider is on a side of the enclosure and is coupled to advance and retract the sample-collecting head, typically using a thumb. The knob is rotated by the user to rotate the sample-collecting head while the enclosure remains in the user's vaginal canal.

An endocyte cannula is designed to provide improved and more productive Pap smear tests. The endocyte cannula includes a proximal portion and a distal portion. The proximal portion may include a fitting to connect to a user-actuated tool, such as a syringe. The distal portion may include a corkscrew feature or a lateral wing feature to facilitate movement of the cannula through dense tissue as well as provide scraping or brushing capabilities. The shaped scraping or brushing features may be provided on an attachment that is attachable to a shaft of the endocyte cannula. The attachments may allow customization of the endocyte cannula based on the physiology and anatomy of a patient. The distal portion may further include a plurality of apertures to aspirate mucus and reduce the risk of trauma or perforation. The apertures may extend outside of the attachment or shaped scraping or brushing features, and the distal portion may be narrower than the shaped scraping or brushing features to facilitate access into the endocervical canal and aspiration and collection of a cell sample.

An everting balloon system is disclosed that can be used for biopsy within a body of a patient or animal. The everting balloon system can be used to access a bodily cavity or vessel for tissue specimen collection at specific bodily locations. The everting catheter system described simplifies the process of tissue biopsy.

Methods provide for the concurrent evaluation, detection and treatment of actual or potential medical conditions at a site of a body, and are particularly directed to medical procedures and concurrent treatment of areas of the body that are difficult to visualize; and a kit providing apparatus for carrying out evaluation, detection and real-time treatment of the site of a body for actual or potential medical conditions is disclosed.

The present invention comprises methods and devices comprising a scraping element used to contact circumferentially and longitudinally the surface walls of the uterine cavity to provide for broad contact of the intended surface with the device, resulting in attainment of a sufficient volume and comprehensive tissue sample for analysis as an endometrial biopsy or screening uterine cancer. The device may provide for a reservoir for the obtained sample to be contained when removing from the uterine cavity, cervical canal, and vagina. The device may be comprised of a detachable means or be of a material that allows the user to cut the sampling head of the device for placement in collection means to maximize the amount of tissue or cells being sent to the laboratory for analysis.

The present invention relates to a method for self-collecting intravaginal sample for HPV test. The self-collecting intravaginal sample apparatus of the present invention comprises: an open end part, a closed end part, a tube providing an inner space that a finger could enter to insert an apparatus into women's vagina, a collecting part collecting intravaginal sample and attached outer surface of the closed end of the tube, and a turner preventing the collecting part being contaminated from an outer contaminant; wherein the collecting part collects a sample from the vagina by turning over the tube inside out so that collecting part may place inside of the tube.

The present invention is directed to methods of removing non-target DNA contamination from sample. The invention additionally is directed to the analysis of fetal DNA from an endocervical sample.