A biopsy device comprises a coring and transport assembly and a distal beak assembly. The distal beak assembly may be coupled to or near a distal end of the coring and transport assembly and may comprise at least one movable cutting element. The distal beak assembly may be configured to rotate about an axis, and assume at least a first open configuration operative to enable the at least one cutting element to core through tissue and a second closed configuration operative to enable the at least one cutting element to move through the tissue and to sever a cored specimen from the tissue.

An automated control, a switch and automated actuator for spring-based end effectors of a medical instrument to be used by a single operator without assistance for multiple biopsy, clipping, clamping, grasping, snaring, cutting, dissecting or other operative functions with electrical connections for cautery or hot biopsy used independently or combined with a rigid or flexible endoscope of any size. The actuator may be a spring(s), gear(s), electrical solenoid or motor, air or hydraulic pressure activated piston or a combination thereof. Automated action may be initiated by a voice, hand or foot operated switch. The actuator may be disposable, attached to or separable from the end effector or permanently attached to be reusable. The actuator and end effector may be disposable, attached to or separable from the endoscope or permanently attached to be reusable. The automated device may be incorporated into an endoscope or attached to the outside.

An automated control, a switch and automated actuator for spring-based end effectors of a medical instrument to be used by a single operator without assistance for multiple biopsy, clipping, clamping, grasping, snaring, cutting, dissecting or other operative functions with electrical connections for cautery or hot biopsy used independently or combined with a rigid or flexible endoscope of any size. The actuator may be a spring(s), gear(s), electrical solenoid or motor, air or hydraulic pressure activated piston or a combination thereof. Automated action may be initiated by a voice, hand or foot operated switch. The actuator may be disposable, attached to or separable from the end effector or permanently attached to be reusable. The actuator and end effector may be disposable, attached to or separable from the endoscope or permanently attached to be reusable. The automated device may be incorporated into an endoscope or attached to the outside.

A catheter assembly for navigation including a flexible catheter having a proximal portion adjacent a proximal end and a distal portion adjacent a distal end and defining a longitudinal axis, the flexible catheter defining a lumen extending therethrough along a longitudinal axis and configured to enable translation of an instrument from the proximal end to the distal end. The flexible catheter defines a compound curve formed on the distal portion, wherein the compound curve includes an elbow bend and a radially curved portion. The elbow bend deflecting the distal portion of the flexible catheter from the longitudinal axis, while the radially curved portion extends from the elbow bend farther deflecting the distal portion about a center point. The catheter guide assembly for navigation includes a control handle disposed at the proximal end of the flexible catheter and is configured to advance and rotate the flexible catheter within a luminal structure.

An adaptor may include a shell and a plunger positioned at a first end of the shell and moveable between an undepressed state and a depressed state. The adaptor may further include a ramp extending from a second end of the shell and a carrier coupled to the ramp. In the undepressed state, the carrier may be located at a first position along the ramp, and wherein, in the depressed state, the carrier may be located at a second position along the ramp, wherein the second position may be closer to the second end of the shell than the first position.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

Shapeable guide catheters and methods for manufacturing and using such shapeable guide catheters. In one embodiment, the shapeable guide catheter comprises a tubular member having a shapeable region, a malleable shaping member attached to the shapeable region such that, when the shape of the shapeable region is changed from a first shape to a second shape, the shaping member will plastically deform to thereafter substantially hold the shapeable region in the second shape, a tubular outer jacket disposed about the outer surface of the tubular member and a tubular inner jacket disposed within the lumen of the tubular member. The shapeable region of the guide catheter may be manually formed into a desired shape before insertion of the guide catheter into the body. In some embodiments, the guide catheter is sized to be inserted through a nostril of a human patient and used to guide the transnasal insertion of another device (e.g., a guidewire, catheter, etc.) to a desired location within the nose, throat, ear or cranium of the subject.

Example embodiments relate to endoscopic systems. The system includes first and second main bodies. First main body includes first end section, which includes a first anchor assembly and first proximal portion. First anchor assembly includes first and second expandable members and first negative pressure opening. First and second expandable members are each configured to transition between a non-expanded configuration and an expanded configuration. First negative pressure opening is configured to apply negative pressure. First proximal portion is secured to the first anchor assembly. First proximal portion includes a bendable portion configured to selectively move the first anchor assembly in a plurality of directions. Second main body includes first and second end sections and main cavity. First end section of second main body includes a second anchor assembly, which includes third and fourth expandable members and second negative pressure opening. Second negative pressure opening is configured to apply a negative pressure.

A surgical instrument for removing biological tissue during a surgical procedure comprises an elongate shaft and an end effector connected to the elongate shaft, the end effector including an edge configured to remove tissue, wherein curvature of one or both of the elongate shaft and end effector is adjustable to position the edge along a tissue surface when the curvature of the one or both of the elongate shaft and end effector is adjusted. A method of incising target tissue from an anatomic wall comprises inserting a shaft of a surgical instrument into an anatomic chamber of a patient, positioning a tissue-removal device connected to the shaft proximate the target tissue, deflecting an axis of the tissue-removal device relative to a central axis of the shaft, and shaving a surface of the anatomic wall by moving the tissue-removal device in a deflected state along the target tissue.

Disclosed herein are various systems and methods for guiding, supporting, and/or housing instruments. One exemplary system includes a guide tube having a manipulation section and mated with rails carrying instrument control members. Moving the rails with respect to the guide tube, or another point of reference, can control movement of the manipulation section.