The present invention provides purification strategies for sterically demanding, i.e. large and pleomorphic, infectious virus particles or VLPs derived therefrom, preferably having a measles virus scaffold to yield fractions or compositions with a significantly reduced content of contaminating host cell DNA and a reduced content of further process-related impurities. Further provided are methods of propagating and purifying infectious virus particles having a measles virus scaffold suitable to provide a preparation having a strongly reduced content of contaminating host cell DNA and a reduced content of further process-related impurities for immunogenic or anti-tumor purposes. In addition, immunogenic and vaccine compositions based on the above methods are provided. Finally, there are provided immunogenic or vaccine compositions produced by the disclosed methods, which are suitable for use in immunogenic or prophylactic vaccination treatment of a subject in need thereof.

The present invention relates to a method for prevention and/or reduction of aggregation of viral components.

A process is provided for storing a lipid containing composition in a biodegradable material, the method comprising the steps: a) providing a biodegradable material, wherein the biodegradable material comprises or consists essentially of a processed starch; b) providing the lipid containing composition, wherein the lipid containing composition comprises lipid nanoparticles, preferably providing a liquid formulation comprising the lipid containing composition and a liquid carrier; c) absorbing said a lipid containing composition into the biodegradable material; and d) storing the lipid containing composition in the biodegradable material at a storage temperature from 80 C. to 80 C. for a period of at least one day. The invention further provides a product obtainable by the process of any one of the preceding claims, the product comprising said lipid containing composition comprising lipid nanoparticles, which are accommodated inside said biodegradable material.