Methods for stabilizing a liquid vaccine for mucosal use are provided. In certain aspects, the methods may include combining a liquid comprising at least one antigen or antigen encoding composition with a petrolatum carrier.

Embodiments of the present invention provide for novel compositions and methods for making and using thermostable enveloped viruses. Certain embodiments relate to formulating enveloped viruses alone in a aqueous formulation, or in combination with spray-drying, lyophilization or other drying techniques to reduce degradation and/or preserve activity or titer of the enveloped virus reducing titer loss, prolonging storage stability, delivery, and use. In some embodiments, formulations disclosed herein create a stabilized envelope virus formulation for protection from high temperature during drying processes for an enhanced and rapid drying process for storage, transport and later use of the stabilized envelope viruses.