Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a permeable implant having a radially constrained state configured for delivery within a catheter lumen, an expanded state, and a plurality of elongate filaments that are woven together. The permeable implant may include a support structure having a plurality of scaffolding filaments where each of the plurality of scaffolding filaments has a diameter that is larger than a diameter of each of the plurality of elongate filaments of the first permeable shell.

A device comprises at least one processor and a memory comprising instructions that when executed by the at least one processor cause the at least one processor to: generate a first signal that causes a vibration device to vibrate, the vibration device being in force-transmitting contact with a first anatomical element; receive, from a sensor, a second signal based on sensed vibration in a second anatomical element proximate the first anatomical element; and determine, based on the second signal, an amount of mechanical coupling between the second anatomical element and the first anatomical element.

An endoscopic surgical tool including a housing having a proximal end and a distal end, the housing having a central axis and a first aperture forming an opening disposed at the distal end, an insulator disposed within the housing and having a central bore and a second aperture, the insulator configured to extend distally from the first aperture along the central axis, and a knife disposed within the first aperture and including a tip. The knife having a retracted position and an extended position, wherein in the extended position, the knife is extended distally from the first aperture along the central axis and in the retracted position, the knife is retracted proximally towards the proximal end along the central axis. The endoscopic surgical tool including a biasing element coupled to the knife and biasing the knife toward the retracted position when the knife is in the extended position.

An endovascular coil includes a radiolucent permanent shape memory or shape-retaining polymer core that retains its coil shape with passage through a catheter, and a temporary degradable radiopaque coating surrounding the permanent shape memory or shape-retaining polymer core.

A closure system for delivering a sealant to an arteriotomy. A distal section of the closure system can include overlapping inner and outer sleeves that can expand with expansion of the sealant. A proximal section of the closure system can include a handle portion and a sheath adapter extending from the handle portion. The handle portion can comprise one or more actuators that when depressed or engaged can assist in deployment of the sealant in the arteriotomy and can further include tamping of the sealant and/or retraction of an expandable member. The sheath adapter can removably engage a side port or an irrigation line of a standard procedural sheath. When the sheath adapter is secured to the procedural sheath, movement of the closure system can also move the procedural sheath.

An improved method and device are provided for forming and/or maintaining a percutaneous access pathway. The device generally comprises an access pathway. The provided assembly substantially reduces the possibility of injury while accessing and/or re-accessing a body space.

An endoscopic instrument (1, 134), for inserting into a body of a patient, has through a tubular the shaft (3, 47, 137) and at least two electrical, mechanical and/or optical line (11, 13, 15, 57, 59, 65, 67, 123, 181) extending through the shaft (3, 47, 137): a fluid channel (7, 53) which directly surrounds the at least two line (11 ,13, 15, 57, 59, 65, 67, 123, 181) which run through the shaft (3, 47, 137) is formed in the shaft (3, 47, 137).

An endoscopic instrument (1, 134) for inserting into a body of a patient includes a tubular shank (3, 47, 137) and at least two electrical, mechanical and/or optical leads (11, 13, 15, 19, 57, 59, 65, 67, 123, 181) which run through the shank (3, 47, 137). A fluid channel (7, 53) is formed in the shank (3, 47, 137). The instrument includes a sealing device (89) which forms a proximal end of the fluid channel and comprises feed-throughs (93, 97, 99, 101, 103) for the leads (11, 13, 15, 19, 57, 59, 65, 67, 123, 181).

An endoscopic instrument (1, 134), for inserting into a body of a patient, includes a tubular shank (3, 47, 137) which is coupled or can be coupled to a handling device (5, 135) and is with a working channel (15). A shank tool can be led through the working channel (15). The working channel (15) includes a proximal working channel opening (153) for inserting the shank tool and a fluid inlet (148) which is separate from the proximal working channel opening.

A computer-assisted surgical system comprises a master grip input mechanism, a surgical instrument comprising an end effector configured to apply a gripping force, and a controller. The controller is configured to receive a first input signal in response to grip input at the master grip input mechanism. The controller is further configured to receive a second input signal after receiving the first input signal, wherein the second input signal is received in response to a procedure input at a master input device, with the procedure input being different from the grip input at the master grip input mechanism and further being indicative of a user's readiness to operate the surgical instrument to perform a first surgical procedure. The controller is further configured to, in response to receiving the first input signal and the second input signal, cause one or more degrees of freedom of the surgical instrument to be placed in a locked state.