A high intensity focused ultrasound (HIFU) system (100,400) for selectively sealing a vessel network (360) in a liver includes a generator (110,410,420) configured to generate and supply electric power, and an acoustic assembly (200,130,150) configured to receive the supplied electric power. The acoustic assembly (200,130,150) includes a first transducer (310,430) configured to generate vibrations having a first frequency, and a second transducer (320,440) configured to generate vibrations having a second frequency. When a first focal point of the generated vibrations having the first frequency and a second focal point of the generated vibrations having the second frequency are aligned within a focused region (350), a group of vessels (360) at the focused region (350) are selectively sealed.

Described herein are systems, devices, and methods for closing a perforation in any hollow vessel associated with a mammalian surgical procedure, for example a device for sealing an aperture in a tissue, the device comprising an implant and a delivery shaft configured to engage the implant, the delivery shaft comprising (i) a retaining sleeve, (ii) a release sleeve, and (iii) a handle coupled to the delivery shaft.

Disclosed is a device (100) for treatment of anal fistula. The device comprises a hollow wire (110) comprising a first end (112) and a second end (114) opposite to the first end, the hollow wire is operable to be received by a fistula track with both first and second ends projecting out of the fistula track. The device also comprises an insert (120) operable to be partially inserted into the first end of the hollow wire and to project out of the first end. The device further comprises an applicator (130) operable to be removably arranged on the second end of the hollow wire when the hollow wire is placed in the fistula track. The applicator is operable to be held for enabling the projected out insert to be inserted into second end for detachably coupling the first and second ends to form a closed loop around the fistula track.

A system to facilitate sealing a puncture of a vessel includes an implant having first and second expandable sections, and a delivery device that includes an inner tube and a circumscribing outer tube. The outer tube defines a first lumen configured to retain the implant, and a second lumen configured to channel fluid from the vessel through a distal opening proximal to the implant. A pusher circumscribed at least partially by the outer tube is configured to compress the implant to selectively expand the first and second expandable sections. The outer tube is selectively retractable relative to the inner tube such that the first expandable section remains substantially within the first lumen and the second expandable section is positioned outside of the first lumen. The outer tube is further selectively retractable relative to the inner tube such that the first expandable section is positioned outside of the first lumen.

Described herein is a medical device for treating a target site, the medical device including, a proximal end including a disc and a distal end including a lobe. The disc and the lobe are connected by a connecting member. The lobe includes a proximal portion defining a proximal surface of the lobe, a distal portion defining a distal surface of the lobe, and a middle portion connecting and extending between the proximal portion and the distal portion. A first transition between the proximal portion and the middle portion is curved, and a second transition between the middle portion and the distal portion is curved. The medical device also includes a plurality of stabilizing wires coupled to the lobe at a radially outer surface of the middle portion, each stabilizing wire including a hook portion extending radially outward from the at least one lobe.

A prosthesis and a method of plugging or covering a trocar tract with the prosthesis is disclosed. The prosthesis includes a tubular body having a proximal end and a distal end, a respective opening at each end, and a channel extending between the proximal end of the tubular body and the distal end of the tubular body. The prosthesis is removably mounted along a trocar. The trocar is removable from the prosthesis such that the prosthesis is left at the trocar tract when the trocar is removed from the tract. The prosthesis includes a delivery configuration and a deployed configuration. In the deployed configuration, the opening at the distal end of the tubular body is smaller than the opening at the proximal end of the tubular body.

A system to facilitate sealing a puncture of a vessel includes an implant having first and second expandable sections, and a delivery device that includes an inner tube and a circumscribing outer tube. The outer tube defines a first lumen configured to retain the implant, and a second lumen configured to channel fluid from the vessel through a distal opening proximal to the implant. A pusher circumscribed at least partially by the outer tube is configured to compress the implant to selectively expand the first and second expandable sections. The outer tube is selectively retractable relative to the inner tube such that the first expandable section remains substantially within the first lumen and the second expandable section is positioned outside of the first lumen. The outer tube is further selectively retractable relative to the inner tube such that the first expandable section is positioned outside of the first lumen.

A medical device may include an outer assembly having a first shaft, a first lumen extending through the first shaft, and an atraumatic first tip removably coupled to a distal end of the first shaft; an inner assembly configured to extend through the first lumen of the outer assembly, the inner assembly including a second shaft, a second lumen extending through the second shaft, and a second tip removably coupled to a distal end of the second shaft, the second tip being configured to pierce tissue; and a plug assembly configured to extend through the second lumen of the inner assembly, the plug assembly including a third shaft and a plug removably coupled to a distal end of the third shaft.

In accordance with some non-limiting examples of the disclosed subject matter, a method of reducing pneumothorax in a percutaneous lung procedure using a cannula having a lumen extending from a first opening to a second opening and having a third opening arranged along a length of the lumen is provided. The reservoir containing a liquid sealant is coupled to the third opening of the cannula. While the cannula is arranged within a subject such that the second opening of the lumen opens into a pleural cavity of the subject, the liquid sealant is injected from the reservoir into the lumen such that the liquid sealant flows out of the second opening of the cannula into the pleural cavity. With liquid sealant sealing the pleural cavity, the cannula is withdrawn from the pleural cavity such that air is unable to infiltrate the pleural cavity by way of the liquid sealant.

Surgical assemblies and related methods are provided for using an actuator to deploy an coupler configured to close a tissue puncture or natural opening in the body, or to create an anastomosis. The surgical assembly includes an actuator including an elongate shaft, a deployable coupler coupled to a distal end of the elongate shaft. The deployable coupler includes a plurality of proximal slits therein configured to form a proximal wing and a plurality of distal slits therein configured to form a distal wing. The actuator assembly is configured to transform the deployable coupler from a delivery configuration in which the proximal wing and the distal wing are substantially parallel to the elongate shaft to a fully-deployed configuration in which one of the proximal and distal wings is substantially perpendicular to the elongate shaft and the other one of the proximal and distal wings is skew to the elongate shaft.