An example closure device is disclosed. The closure device includes a framework including a first end region, a second end region and a medial region extending therebetween. The medical device also includes a biodegradable tissue ingrowth member extending over at least a portion of the framework, wherein the tissue ingrowth member is configured to promote tissue ingrowth thereupon, and wherein the tissue ingrowth is configured to seal an opening in the heart.

Apparatus for sealing a vascular wall penetration disposed at the end of the tissue tract comprises a shaft, an occlusion element, a hemostatic implant, and a protective sleeve. The apparatus is deployed through the tissue tract with the occlusion element temporarily occluding the vascular wall penetration and inhibiting backbleeding therethrough. The hemostatic implant, which will typically be a biodegradable polymer such as collagen carrying an anti-proliferative agent or coagulation promoter, will then be deployed from the sealing apparatus and left in place to enhance closure of the vascular wall penetration with minimum scarring. The implant may be radiopaque to allow observation before release.

An occluder includes a first occluder disc, a second occluder disc, a waist portion connecting the first occluder disc and the second occluder disc, and at least one soft and fibrous strand bundle structure. The strand bundle structure is disposed on at least one of a disc surface of the first occluder disc and a disc surface of the second occluder disc, the two disc surfaces faces each other, and the strand bundle structure is disposed near the waist portion. By disposing the strand bundle structure to be immediately adjacent to the waist portion, a defect opening can be occluded after implantation, thereby effectively blocking blood from flowing from one side of the defect to the other side thereof, and preventing a shunt from being formed.

Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

The present invention relates to a vascular closure device for sealing a puncture site in a vascular wall comprising a sheath (10) having a distal end and at least one proximal end, wherein the sheath (10) comprises a tubular body (100). The vascular closure device (1) is characterized in that at least one distal balloon member (11) is firmly arranged at the distal end of the tubular body (100) of the sheath (10) and at least one expandable anchor member (12) is firmly arranged proximal to the distal balloon member (11) on the tubular body of the sheath (10), wherein at least the distal side of the distal balloon member (11) is a pressure area for applying pressure on the outside of the vascular wall. Furthermore a method of positioning of a vascular closure device (1) is described.

Disclosed herein is a method of producing high purity pentagalloyl glucose (PGG), analogues or derivatives thereof, at least 99.9% pure, by washing with dimethyl ether. PGG may be provided in a kit, including a hydrolyzer for dissolving the PGG and a saline solution. Also disclosed herein is a device for delivery of a therapeutic solution to a blood vessel. The device may be a catheter having an upstream balloon and a downstream balloon. The upstream balloon may be expanded to anchor the catheter and occlude antegrade blood flow. The downstream balloon may be expanded to occlude retrograde blood flow, creating a sealed volume within the blood vessel. The downstream balloon may have pores configured to deliver a therapeutic inflation solution into the sealed volume or a portion thereof. The downstream balloon may be expanded by the expansion of a balloon disposed inside the downstream balloon.

A system is provided for causing hemostasis at a puncture and a puncture tract. The system includes an inner member comprising an expandable member at its distal end and an inflation lumen that extends from inner member proximal end to an interior of the expandable member. The system further includes an outer member comprising a lumen sized and shaped to allow the inner member to slide therein, an occlusion balloon at its distal end, and an inflation lumen that extends from its proximal end to the interior of the occlusion balloon. The expandable member can be inflated by fluid flowing through the inner member inflation lumen so that the expandable member can close a puncture in a subcutaneous vessel of a living being. The occlusion balloon can be inflated by fluid flowing through the outer member inflation lumen so that the occlusion balloon can contact and apply pressure to a puncture tract extending from the skin of the living being to the puncture.

A hemostatic device is provided with: a first tubular member; a positioning member having a first engagement section and engageable with an opening of a blood vessel; a hemostatic agent arranged further to a proximal end side than the first engagement section of the first positioning member; a push-out member making it possible to push the hemostatic agent out from a distal end section of the first tubular member when the push-out member is moved; a first operation unit for executing a first distal end operation for causing the first tubular member and the push-out member to move in a relative manner to a distal end side, and a second distal end operation for causing the push-out member to move in a relative manner to the distal end side; and a switching mechanism for restricting the second distal end operation until the first distal end operation is completed.

A method of manufacturing a reduced-pressure abdominal treatment system for treating an open abdominal cavity is provided. In some embodiments, the reduced-pressure abdominal treatment system has an open-cavity treatment device for providing reduced-pressure treatment to an abdominal cavity; a deep-tissue closure device for applying a closing force on a deep-tissue wound; and a surface-wound closure subsystem for providing a closing force on a surface wound. The method of manufacturing may also include providing a reduced-pressure supply subsystem. A method of treatment using a reduced-pressure abdominal treatment system is also disclosed.

A puncture sealing system for sealing a vascular puncture comprises an inner member comprising an expandable member at an inner member distal end and an inflation lumen that extends from an inner member proximal end to an interior of the expandable member. The puncture sealing system also comprises an outer member comprising a lumen sized and shaped to allow the inner member to slide therein, an occlusion balloon at an outer member distal end, and an inflation lumen that extends from an outer member proximal end to the interior of the occlusion balloon. The expandable member can be inflated by fluid flowing through the inner member inflation lumen so that the expandable member can inflate in a subcutaneous vessel of a living being, and the occlusion balloon can be inflated by fluid flowing through the outer member inflation lumen so that the occlusion balloon can enable the occlusion of a vascular puncture and contact and apply pressure to a puncture tract extending from the vascular puncture. In one version, the inner member further comprises a vessel locator system. In one version, the puncture sealing system further comprises an obturator slidably receivable within the outer member and having a distal end adapted to at least partially cover the puncture.