A cannula assembly for treating a puncture site in a subcutaneous vessel includes a cannula and an elongated sleeve with a bore for receiving the cannula. The elongated sleeve includes a plurality of channels circumferentially spaced about the bore through which at least one of a flow of air can be drawn and a plurality of wires can be advanced to promote the formation of a seal between the elongated sleeve and the subcutaneous vessel around the puncture site. The cannula assembly can further include a plug which can be inserted into the bore of the elongated sleeve following removal of the cannula. A needle for insertion into the subcutaneous vessel includes a rigid shaft with an enlarged segment connected to a hub. The needle and cannula assembly can be utilized in a method for cannulating the subcutaneous vessel.

Microcatheter for delivering a substance (e.g., infusion agent including embolization material and/or contrast enhancing material) in a small blood vessel towards a target bodily part. Includes a single lumen surrounded by tubular wall having outer diameter and opened at both ends; tubular wall proximal portion is connectable to a pressure source and reservoir containing infusion agent, and tubular wall distal portion ends with a tip; the tubular wall distal portion includes an infusion agent flow disruption section configured to disrupt passage therethrough of incoming retrograded flow of infusion agent, during continuous delivery of infusion suspension from the reservoir to the tip. Disclosed are methods using the microcatheter for performing local embolization in a small blood vessel feeding a (for example, cancerous) target bodily part, and for delivering infusion agent in a small blood vessel towards such target bodily part. Also disclosed are devices and methods for filtering non-target infusion agent.

An embodiment is directed to an embolic device comprised of a coil made of a first material and disposed on the inside of a tube structure made of a second material. The tube structure has micro-fabricated fenestrations formed in the tube to provide fluid communication between the lumen of the tube and the surrounding environment, thereby exposing the inner coil. The fenestrations also trip flow around the embolic device. In one embodiment, the embolic device is comprised of a tantalum coil on the inside of a polyetheretherketone (PEEK) tube. The PEEK tube has the advantage of providing a micro-machined delivery implant frame and radiopacity, while the internal tantalum coil provides radiopacity and thrombogenicity. A material other than PEEK may be used for embodiments of embolic devices without departing from the spirit of the disclosure.

A fastener cartridge can comprise a support portion, a tissue thickness compensator positioned relative to the support portion, and a plurality of fasteners positioned within the support portion and/or the tissue thickness compensator which can be utilized to fasten tissue. In use, the fastener cartridge can be positioned in a first jaw of a surgical fastening device, wherein a second jaw, or anvil, can be positioned opposite the first jaw. To deploy the fasteners, a staple-deploying member is advanced through the fastener cartridge to move the fasteners toward the anvil. As the fasteners are deployed, the fasteners can capture at least a portion of the tissue thickness compensator therein along with at least a portion of the tissue being fastened.

Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including CTGF/CCN2, or cells.

A medical fluid suspension generating apparatus for performing medical procedures includes a Venturi-agitating tip assembly composed of a multi-channel arrangement at a proximal first end thereof and a tip at a distal second end thereof. The apparatus also includes a compressed medical fluid unit fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly and a medical solution fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly. Pressurized gas, from the compressed medical fluid unit, and the medical solution are combined within the Venturi-agitating tip assembly in a manner generating an enriched medical suspension that is ultimately dispensed from the suspension delivery apparatus.

A surgical stapling apparatus includes a tool assembly, at least one surgical buttress, and a resilient, porous material. The tool assembly includes a cartridge assembly and an anvil assembly pivotably coupled to the cartridge assembly. The cartridge assembly includes a first tissue facing surface defining staple retaining slots. The anvil assembly includes a second tissue facing surface defining staple pockets for forming staples expelled from the staple retaining slots of the cartridge assembly. The at least one surgical buttress is releasably disposed on at least one of the first and second tissue facing surfaces. The resilient, porous material is releasably disposable between the first and second tissue facing surfaces and in contact with the at least one surgical buttress. The resilient, porous material is configured to expel a liquid therefrom upon compression thereof by an approximation of the cartridge assembly and the anvil assembly.

The present disclosure describes the use of nerve conduits as scaffolds for nerve regeneration, including spinal cord regeneration. The conduit may be hollow or contain a luminal filler such as agar or other biocompatible material.

A stapling assembly comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises a body portion comprising a porous material and a plurality of cavities defined in the body portion, wherein the cavities are aligned with forming surfaces of an anvil such that fasteners of a fastener cartridge are configured to at least one of the cavities when the fasteners are ejected from the fastener cartridge or capture the cavities and compress the cavities within the tissue thickness compensator when the fasteners are ejected from the fastener cartridge and formed by forming surfaces of the anvil. The stapling assembly further comprises at least one medicament positioned within each cavity prior to firing the stapler, wherein the medicament is different than the porous material.

A medical fluid suspension generating apparatus for performing medical procedures includes a Venturi-agitating tip assembly composed of a multi-channel arrangement at a proximal first end thereof and a tip at a distal second end thereof. The apparatus also includes a compressed medical fluid unit fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly and a medical solution fluidly connected to the multi-channel arrangement at a proximal first end of the Venturi-agitating tip assembly. Pressurized gas, from the compressed medical fluid unit, and the medical solution are combined within the Venturi-agitating tip assembly in a manner generating an enriched medical suspension that is ultimately dispensed from the suspension delivery apparatus.