The present invention relates generally to agents and devices for promoting hemostasis and, more particularly, to bioresorbable hemostatic pads or patches releasably supported on non-resorbable scaffolds for ease of delivery in the field. A sealant and/or hemostat delivery device comprises a resorbable hemostatic pad having a wound facing side and an opposite back side, with a hemostatic and/or wound sealing agent disposed on the wound facing side; a non-resorbable scaffold having an attachment zone on said scaffold; wherein said hemostatic pad is releasably attached with the back side to the attachment zone. The bond between the scaffold and the resorbable hemostatic pad or wound dressing is either (i) severed prior to removal of the scaffold or (ii) is weakened due to the adhesive bonding them together being moisture-deactivated, or (iii) is released by mechanical disentanglement.

Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

Methods and devices are provided for promoting wound healing. In general, surgical staplers and stapler components are provided having a coating thereon that is configured to selectively control an interaction between at least one matrix metalloproteinase (MMP) inhibitor and an outer surface of the stapler or stapler component.

A sealant for sealing a puncture through tissue includes a first section, e.g., formed from freeze-dried hydrogel, and a second section extending from the distal end. The second section may be formed from PEG-precursors including PEG-ester and PEG-amine, e.g., in an equivalent ratio of active group sites of PEG-ester/PEG-amine greater than one-to-one, e.g., such that excess esters may provide faster activation upon contact with physiological fluids and enhance adhesion of the sealant within a puncture. At least some of the precursors remain in an unreactive state until exposed to an aqueous physiological environment, e.g., within a puncture, whereupon the precursors undergo in-situ cross-linking to provide adhesion to tissue adjacent the puncture. For example, the PEG-amine precursors may include the free amine form and the salt form. The free amine form at least partially cross-links with the PEG-ester and the salt form remains in the unreactive state in the sealant before introduction into the puncture.

A catheter device (2) is provided for implanting an anchor (9) into body tissue to attach a line (14) to the body tissue. The catheter device (2) comprises: a housing section (4), (8) extending from a distal end of the catheter device (2) along the length of the catheter device (2) toward the proximal end of the catheter device, the housing section (4), (8) comprising a distal part (8) at the distal end of the catheter device (2) and a proximal part 4 located on the proximal side of the distal part (8). An anchor deployment mechanism (106), (110) is provided at the distal part (8) of the housing section (4), (8) for deployment of the anchor (9) for attachment of the anchor (9) to the body tissue. The anchor (9) is held in its stowed position by the anchor deployment mechanism (106, 110) in the distal part (8) prior to deployment, and the anchor (9) comprises a number of hooks (62) for engagement with the body tissue and having a folded position and an unfolded position, wherein the anchor (9) is made of an elastic material such that the hooks (62) can be elastically deformed into the folded position by application of a constraining force, and will return to the unfolded position when no constraining force is applied, and wherein the hooks (62) are held in the folded position whilst the anchor (9) is in the stowed position within the distal part (8). The distal part (8) of the housing (4), (8) has a non-circular shape (118), (117) for engagement with a corresponding non-circular form (28), (108) of the anchor (9) and/or the anchor deployment mechanism (106), (110), such that when the anchor (9) is held in the distal part (8) movement of the anchor (9) is restrained with respect to rotation of the anchor (9) about a longitudinal axis of the distal part (8) due to engagement between the non-circular shape (118), (117) and the non-circular form (28), (108).

A radial compression band employs a substantially rigid U-like cuff that fits over a patient's arm and then snaps onto a tightening band. A movable bubble member is positioned for movement along the band separate from the attachment to the patient and is inflatable to provide pressure to an incision or the like to accomplish hemostasis.

Devices, systems and methods are provided for performing embolization procedures in a desired area of the body. Systems include embodiments of embolization devices having increased durability, flexibility, conformability and surface area that include elongate primary coils that are formed from helically wound elongate initial coils which are formed from helically wound metallic wire and delivery systems used to position the embolization devices at a target location within a lumen of a mammal.

The present invention provides an apparatus for producing medical foam for wound care or hair stimulation. The apparatus includes a foam generation unit having a fluid reservoir, a fluid delivery line and a foam generation tip. The apparatus also includes a compressed gas unit having at least one container of compressed gas, a source of electric power, and a gas regulator valve. A supply of wound care or hair stimulating solution is communicably connected to the foam generation tip such that when the apparatus is operated medical foam is produced by the foam generator tip.

An occlusion clip comprising: (a) a first elongated occlusion arm; (b) a second elongated occlusion arm; (c) a first elongated biasing arm coupled to a distal portion of the first elongated occlusion arm; (d) a second elongated biasing arm coupled to a distal portion of the second elongated occlusion arm, where a proximal portion of the first elongated biasing arm is coupled to a proximal portion of the second elongated biasing arm, where the first elongated occlusion arm extends parallel to the first elongated bias arm along a majority of its length, and where the second elongated occlusion arm extends parallel to the second elongated bias arm along a majority of its length.

A medical device comprising a compressed, inflatable, detachable balloon attached to a catheter and methods of use for occluding blood vessels or treating vascular aneurysms are disclosed. The balloon may be configured such that it can be detached from the catheter by mechanical means. The surface of the balloon may be configured to promote the growth of tissue into the wall of the balloon and to release drugs or pharmacologically active molecules, so that vessel occlusion or the sealing of an aneurysm will be maintained over time.