Biodegradable and resorbable polymer pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices (IMDs), i.e., a pouch, covering, or other receptacle capable of encasing, surrounding and/or holding the CRM or other IMD for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other IMD. Optionally, the biodegradable and resorbable pouches of the invention include one or more drugs in the polymer matrix to provide prophylactic effects and alleviate side effects or complications associated with the surgery or implantation of the CRM or other IMD.

The invention is a half pin for use in conjunction with external fixators, in which the half pin has a thin hydroxyapatite coating over a substantial portion thereof, a not-sharp hole-finding tip, and a variable pitch pattern in the threaded portion of the half pin. The hydroxyapatite coating must be thin—40-70 microns, deposited by plasma spray—and with limited porosity and pore size, and must extend not only over all the threads of the half pin but also a substantial portion of the unthreaded shaft proximal to the threaded end. The invention also includes a pin cube for use in association with the coated half pins. Wires may also be coated with the hydroxyapatite coating.

A shape-formable apparatus comprising locking sheets. The apparatus can have a first state in which the apparatus is formable, and a second state in which the apparatus has the desired shape and is substantially less formable than in the first state. The apparatus can further include an envelope defining a chamber, a port positioned to fluidly couple the chamber with ambience, and at least two locking sheets positioned in the chamber in an at least partially overlapping configuration. Each locking sheet comprises a major surface, and at least a portion of each locking sheet can be patterned to include solid regions and open regions, the solid regions being movable with respect to one another within the major surface.

Method of using a shape-formable apparatus. A shape-formable apparatus can include an envelope defining a chamber, a port positioned to fluidly couple the chamber with ambience, and at least two locking sheets positioned in the chamber in an at least partially overlapping configuration. Each locking sheet can include a major surface, and at least a portion of each locking sheet can be patterned to include solid regions and open regions, the solid regions being movable with respect to one another within the major surface. The method can include providing the shape-formable apparatus in a first state; forming the apparatus into a desired shape; and reducing the pressure in the chamber to change the apparatus from the first state to a second state in which the apparatus is substantially less formable than in the first state.

A stapling assembly comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises a body portion comprising a porous material and a plurality of cavities defined in the body portion, wherein the cavities are aligned with forming surfaces of an anvil such that fasteners of a fastener cartridge are configured to at least one of the cavities when the fasteners are ejected from the fastener cartridge or capture the cavities and compress the cavities within the tissue thickness compensator when the fasteners are ejected from the fastener cartridge and formed by forming surfaces of the anvil. The stapling assembly further comprises at least one medicament positioned within each cavity prior to firing the stapler, wherein the medicament is different than the porous material.

An electromechanical surgical assembly includes a surgical device, an adapter, and a filter. The surgical device includes a connecting portion having a distal facing recess including an electrical plug. The adapter includes a proximal facing cap configured to mate with the recess of the surgical device, the proximal facing cap including an electronic assembly including a plurality of electrical contact pins configured for electrical connection with the electrical plug. The filter is removably positioned within the recess of the surgical device. The plurality of electrical contact pins extend through the filter when the adapter is connected to the surgical device.

A two-part tissue thickness compensator assembly can include a first tissue thickness compensator configured to be positioned relative to an anvil of a surgical stapler, a second tissue thickness compensator configured to be positioned relative to a staple cartridge of the surgical stapler, and a hinge connecting the first tissue thickness compensator to the second tissue thickness compensator. The first and/or second tissue thickness compensators may include additional engagement features, such as a raised ridge that engages a slot in the anvil and/or the staple cartridge. In certain embodiments, the first and/or second tissue thickness compensators may include an encasement that contains a suitable biologic agent. An end effector assembly may be provided for attachment to a surgical instrument that includes, for example, a staple cartridge, an anvil, a first tissue thickness compensator positioned on the anvil, and a second tissue thickness compensator positioned on the staple cartridge.

The present invention provides a drug eluting surgical screw and a method for manufacturing a drug eluting surgical screw. The drug eluting surgical screw may include a shaft having a threaded portion, a head having a drive recess disposed at a proximal end of the shaft, the drive recess having a reservoir region and a driver engagement region, and at least one or more drug eluting components disposed within the reservoir region of the drive recess in a manner that does not substantially impair a connection between a driver and the surgical screw when the driver is operably disposed within the driver engagement region, each of the at least one or more drug eluting components including a carrier matrix and a therapeutic agent, the therapeutic agent being at least 20 wt % of the drug eluting component prior to any implantation of the drug eluting surgical screw.

An end effector including an anvil and a staple cartridge assembly is disclosed. The staple cartridge assembly comprises a deck having steps defined thereon for compressing tissue positioned between the anvil and the staple cartridge assembly to different pressures. The staple cartridge assembly further comprises staples having different unformed heights removably stored therein. The staples are deformed against the anvil to different formed heights.

A staple cartridge comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises an uncompressed height, a compressed height, an outer encasement, and tubular structures aligned along the longitudinal axis. The tubular structures are configured to collapse when pressure is applied to the tissue thickness compensator by tissue during the firing motion.