Apparatus and methods are provided for occluding blood vessels and other anatomical structures. Occlusion devices are delivered percutaneously and extraluminally through a small gauge needle and include expandable elements that are deployable on opposite sides of a target vessel to be occluded. When positioned about the vessel the elements are expanded and brought together to compress and occlude the vessel. Embodiments include those adapted for temporary as well as permanent use.

Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The left atrial appendage device may include an expandable frame configured to shift between a first configuration and an expanded configuration. A fabric mesh may be disposed along at least a portion of the expandable frame. An anti-thrombogenic coating may be disposed along the fabric mesh.

Disclosed herein are medical devices comprising a single-lobed, thin-walled, expandable body and a flexible, elongated delivery device for treating saccular vascular aneurysms and occluding segments of blood vessels and other biological conduits. The expandable bodies may include gold and other metals that can be compressed, positioned in the lumen of an aneurysm, or other biological conduit and expanded. The external surface of the expandable bodies can be configured to promote local thrombosis and to promote the growth of tissue into and around the surface in order to reduce migration of the expandable body and to occlude and seal the aneurysm or biological conduit. For the treatment of saccular aneurysms, the expandable body may be deployed in combination with one or more coiled wires that contact both the wall of the aneurysm and the expandable body and exert force on the expandable body to aid in sealing the aneurysm neck.

A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

A clip for reducing a dimension of an opening in tissue may include a continuous member having a plurality of legs and a plurality of preformed bends connecting adjacent legs, wherein the plurality of legs form: a first group having two protrusions; a second group having two protrusions; and a third group having two protrusions, wherein each protrusion of each group includes two legs of the continuous member and a corresponding preformed bend connecting the two legs, and each protrusion of each group extends from a region adjacent a first end of the clip to a region adjacent a second end of the clip.

A hemostasis pressure device is disclosed. In one embodiment, the hemostasis pressure device includes a reusable component and a disposable cuff. The disposable cuff includes a pre-inflated pad configured to be placed at an access site on a patient. A knob secured to the reusable component is configured to control the pressure applied to the pre-inflated pad, providing incremental, fine-tuned control of pressure applied to the access site to achieve patent hemostasis.

In general, adaptive responses from smart packaging of drug delivery absorbable adjuncts and methods of using smart packaging of drug delivery absorbable adjuncts are provided.

In various embodiments, a tissue thickness compensator can comprise a compressible extracellular matrix and a bioabsorbable material dispersed within the extracellular matrix, wherein the bioapsorption of the bioabsorbable material is configured to leave behind channels in the extracellular matrix. The tissue thickness compensator can also comprise generation means for generating the ingrowth of tissue into the channels. In at least one embodiment, the tissue thickness compensator can comprise dissolvable wicking members which, when dissolved, can leave behind channels in the tissue thickness compensator. In certain embodiments, the tissue thickness compensator can comprise at least one rupturable capsule.

Various exemplary devices and methods are provided for performing surgical procedures. In general, one or more adjuncts can be used in conjunction with surgical instruments. The adjunct(s) can have medicant(s) thereon and/or therein. The medicant(s) can vary depending on the desired effect of the medicant(s) on surrounding tissue. As a non-limiting example, medicant(s) can be provided to influence hemostasis, inflammation, macrophages, and/or fibroblasts. When used in conjunction with a surgical stapler, the adjunct(s) can be disposed between and/or on jaws of the stapler, incorporated into a staple cartridge disposed in the jaws, or otherwise placed in proximity to the staples. When staples are deployed, the adjunct(s) can remain at the treatment site with the staples.

This invention relates to an aneurysm occluder, and more particularly but not exclusively, to an endovascular aneurysm occluder that can be inserted into an aneurysm cavity by using endovascular surgical procedures. The aneurysm occluder has a deformable housing and an absorber or material that causes blood clotting made of an absorbent material in or attached to the housing.