Surgical instruments and their methods of use are disclosed. In some embodiments, the surgical instrument may include a handle and an elongated shaft assembly extending distally from the handle. The surgical instrument may also include a fastener deployment system for deploying fasteners from the elongated shaft assembly including a reciprocating driveshaft disposed within the elongated shaft assembly. The driveshaft may include an internal channel and at least one guide surface shaped and arranged to maintain an orientation of at least one fastener in the channel of the driveshaft. In other embodiments, the fastener deployment system may include a follower disposed within the elongated shaft assembly for displacing one or more fasteners within the elongated shaft assembly towards a distal fastener deployment position.

A blood vessel treatment method including inserting a medical device into a blood vessel, the medical device including an elongate shaft portion and a contact portion configured to contact a biological tissue in the blood vessel; bringing the contact portion into contact with the biological tissue in the blood vessel; twisting the blood vessel by moving the contact portion; and releasing a treatment agent from the medical device for occluding or contracting a lumen of the blood vessel.

Devices, systems, and methods for use with suction within a mammalian body. In an exemplary embodiment of a device of the present disclosure, the device comprises one or more of the following: an inner tube, an outer tube, and a foldable portion, whereby movement of the two tubes relative to one another causes the foldable portion to form a suction cup, and conversely causes a suction cup to form a foldable portion, depending on the direction of relative movement.

An open catheter has at least eight splines making up a basket. Each of the splines includes at least six electrodes. An arm is provided connected to and capable of moving the splines from a closed position to an open position, and multiple positions therebetween.

Various devices, systems, and methods are provided for allowing surgical instruments to access a body cavity through an access device, such as a cannula. In one embodiment, a cap can be removably and replaceably coupled to a proximal end of cannula and can have an opening therethrough that communicates with an inner passageway of the cannula. Various surgical elements can be passed through the cap and cannula and into a patient when the cannula is positioned within the patient. The cap can have a side slot formed therein. The slot can be configured to allow surgical elements, such as sutures, to pass through the cap and into the cannula. At least one surgical seal can be in the cap and can be configured to receive surgical elements therethrough.

Marking device (100) for implantation into a tissue (260), having a support structure (102) which is formed by at least one elastic metal wire, is compressible and is self-expanding and which, in an expanded state, encompasses an interior space (104), characterized in that the marking device (100) is designed to transform itself on its own from a compressed state into an expanded state, even against a tissue pressure prevailing at a tissue site to be marked, and the marking device (100) in the expanded state has a hollow, approximately spherical shape.

An endoluminal punch system including a sheath and dilator. The endoluminal punch may include energy delivery system capable of being transmitted from the proximal end to the distal end of the endoluminal punch to assist with tissue crossing and incisions. The dilator may include selectively deployable cutting mechanism to create incisions in tissue that are larger than their basic external diameter. The system may also be configured to reduce the risk of generating plastic emboli during insertion of the endoluminal punch.

An apparatus includes a body, a shaft, and a stapling head assembly. The shaft extends distally from the body and includes a coupling feature. The coupling feature includes threading or at least one barb. The stapling head assembly is configured to cut and staple tissue. The stapling head assembly is positioned at a distal end of the shaft. The stapling head assembly includes a knife member and a body member. The knife member includes a circular cutting edge configured to cut through tissue. The body member is configured to house the knife member. The body member includes a coupling feature that is configured to mechanically couple with the coupling feature of the shaft. The coupling feature of the body member includes threading or at least one barb.

Marking device (100) for implantation into a tissue (260), having a support structure (102) which is formed by at least one elastic metal wire, is compressible and is self-expanding and which, in an expanded state, encompasses an interior space (104), characterized in that the marking device (100) is designed to transform itself on its own from a compressed state into an expanded state, even against a tissue pressure prevailing at a tissue site to be marked, and the marking device (100) in the expanded state has a hollow, approximately spherical shape.

A catheter system for delivering an anchor to a valve annulus in a heart valve includes a locating catheter and an anchor delivery catheter. The locating catheter has a distal end which can be advanced beneath the valve annulus near a target site on an upper surface of the valve annulus. The anchor delivery catheter has a distal end which can be advanced over the valve annulus to deliver an anchor along a delivery path to the target site. The distal end of the locating catheter has at least one magnetic element, and the distal end of the anchor delivery catheter has at least one magnetic element which attracts the at least one magnetic element on the locating catheter to pivotally couple the distal end of the anchor delivery catheter to the distal end of the locating catheter. In this way, the deliver catheter can be pivoted relative to the locating catheter to orient the delivery path away from the locating catheter.