Devices and methods for joining a first and second tissue in a patient are disclosed that include a base with opposed first and second surfaces, and a plurality of recurved tines oriented to a tine axis and extending from the first surface of the base. The base defines four suture holes extending through the first and second surfaces of the base and configured to receive at least one suture passing between the first and second surfaces of the base. The plurality of recurved tines provides unidirectional traction of the first tissue along the tine axis toward the first surface to secure the device to the first tissue. The device is secured to the second tissue at the second surface with the at least one suture secured to at least one anchor secured to the second tissue.

A system for reducing regurgitation includes a catheter and a coaptation member disposed along a distal end portion of the catheter, wherein the coaption member is sized to be advanced through a patient’s vasculature in a compressed configuration and wherein the coaptation member is expandable for deployment between leaflets of a native tricuspid valve. The coaptation member includes a frame covered with one or more panels of bioprosthetic tissue or flexible polymer to form a three-sided shape having three convex sides separated by rounded corners. An anchor is coupled to a proximal end portion of the catheter and is shaped for attachment to a vessel wall. After deployment, the anchor secures the position of the coaptation member relative to the native tricuspid valve.

Novel orthopedic staples and related instruments are disclosed. An instrument is an orthopedic drill guide assembly that includes a first arm and a second arm that are retractably connected to the distal end of the instrument's outer housing, where the proximal ends of the arms are retractably connected to the distal end of the outer housing and configured to move in a retractable motion that changes the spacing between the first drill guide sleeve and the second drill guide sleeve, where the proximal end of the outer housing is configured for controlling the retractable motion of the first and second arms.

An apparatus includes a stapling assembly and an anvil. The stapling assembly includes first and second staples. Each of the first and second staples include first legs. The anvil together with the stapling assembly is configured to clamp tissue of a patient. The anvil includes a first staple forming pocket that is configured to transition the first legs of the first and second staples from a non-deformed state to a deformed state with the same firing stroke.

Systems, devices and methods described herein relate to endovascular devices for delivering sutures for securing grafts or other objects to patient vessels. In some embodiments, a suture includes a set of two legs having proximal ends joined to each other and elongate bodies that extend parallel to one another such that the set of two legs form a U-shaped structure. A suture delivery system can include a housing configured to contain a suture in a flattened configuration, and a deployment element having a ribbon-shaped distal portion disposed in the housing and including a set of formations, where the housing and the set of formations of the deployment element are configured to collectively constrain the suture in the flattened configuration until the suture is released through the opening of the housing.

Suture passer systems for tissue suspension and tissue compression are described. The system can include a shaft and a needle, wherein the needle is freely rotatable with respect to the shaft. The suture may include an overmolded segment. Methods of placing one or more implants, sutures, fastener, bone anchors and other devices are also described. The methods include moving tissue, including the superior pharyngeal constrictor muscle, palatopharyngeal arch, and palatoglossal arch. The methods include hyoid bone suspension.

Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation device that can secure adjacent bones and/or bone portions in a manner that prevents or limits relative rotational movement thereof.

The invention is a staple comprising a bridge member having a top surface and an opposing bottom surface defining a thickness between and two lateral edges defining a width therebetween and either the thickness or the width includes a center flared area, such as a “diamond-like” shape meaning that it has a v-shape on opposing lateral edges flanked by opposing fillets to form an inserter mount area and the staple has a pair of legs spaced apart along the axis and each joined at a rounded flared shoulder to the bridge member. In a four-legged version the bridge has a waist.

The present disclosure includes a plurality of securing devices. For example, the present disclosure includes securing devices comprising sutures, everting anchors, and inverting anchors. The sutures and anchors disclosed herein may be capable of deployment to a depth within a body lumen, such that body tissue external to the body lumen is not damaged by the devices. Moreover, in various embodiments, the securing devices described herein may couple one or more medical devices (e.g., stents, grafts, and/or stent-grafts) to body tissue such as a body lumen.

A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device including a flexible portion that is suited to access target anatomy. The flexibility of an elongate portion of the delivery device can be varied. Additionally, the delivery device can include structure that maintains the positioning of the delivery device in patient anatomy.