This tissue-joining member comprises non-crosslinked fibrous collagen. A laminate body comprises: a support; a joining member that is layered on one surface of the support; and a first adhesive layer that is layered on said one surface of the support in a region on which the joining member is not layered. The method for using the joining member or the laminate body comprises: a heating step in which the joining member or the laminate body is heated to less than 60° C. and greater than body temperature after having being layered on the tissue; and a cooling step in which the heated joining member or laminate body is cooled to body temperature or lower. A treatment system comprises a heating unit and the joining member or the laminate body.

Kits and systems are disclosed that include one or more segments of elastically deformable membrane in combination with one or more external fixation members and optionally in combination with one or more tension protector pads. Also disclosed are methods of use of the kits and systems in methods that involve stretching the elastically deformable membrane and applying the stretched membrane to the skin of a patient, and releasing the tension on the membrane, thus causing compression of the skin to which the membrane is applied. The method may further include the optional steps of inserting one or more external fixation members through the membrane/skin combination and into a bone segment, applying a distraction force to the one or more external fixation members, and separating at least a portion of the membrane so as to release a portion of the tension in the skin at a rate that is similar to a rate at which the distraction force is applied.

A wound closure device is provided. The wound closure device includes a first pad with an adhesive surface and a second pad with an adhesive surface. The wound closure device also includes a first tension adjusting pad with a first section, a first connecting element and a second connecting element. The first tension adjust pad is configured to move the first pad towards the second pad when the first tension adjusting pad is moved away from the first pad. The wound closure device also includes a second tension adjusting pad with a second section, a third connecting element and fourth connecting element. The second tension adjusting pad is configured to move the second pad towards the first pad when the second tension adjusting pad is moved away from the second pad. The wound closure device further includes a first cross bar for securing the first and third connecting elements.

Disclosed herein are devices, systems and methods for using such devices and systems for treating incisions and wounds. In an aspect, disclosed is a device having a generally planar tension relief module and a flexible sealant structure sized to cover the tension relief module, the flexible sealant structure comprising a lower adhesive surface. The tension relief module includes a conduit structure having a plurality of support structures on an upper surface of the conduit structure and at least one opening extending through the conduit structure from a lower surface to the upper surface. At least a portion of the conduit structure is adapted to be aligned with a longitudinal axis of the incision. The tension relief module also includes opposing adhesive structures coupled to the conduit structure. The lower adhesive surface of the flexible sealant structure and the upper surface of the conduit structure form a flow pathway.

A wound closure system and a method of closing a wound are disclosed. The wound closure system includes a plurality of skin anchors mechanically attached to external skin tissue around a periphery of a wound, a line extending between the skin anchors, the line slidably engaged with each skin anchor, a biasing member that provides tension on the line to draw all of the skin anchors toward the wound and a negative pressure wound dressing apparatus adapted to be used in conjunction with the wound closure system. The method of closing a wound includes the steps of attaching a plurality of skin anchors to external skin around a periphery of a wound, extending a line between the skin anchors around substantially the entire periphery of the wound, providing tension to the line to draw the skin anchors toward the wound, and applying a negative pressure to the wound.

A tissue retention system to assist in maintaining adipose tissue on a patient in a displaced position during a medical procedure to provide access to a body region of the patient includes an anchor pad having a pad length and a pad width. The anchor pad may include a pad body with an adhesive surface thereon, the adhesive being configured to adhere to a patient's skin. The anchor pad also may include an opposing first attachment surface facing away from the adhesive surface. The tissue retention system also may include a tension member having a second attachment surface.

An apparatus, system, and method for treating an incisional wound having incisional walls. The apparatus includes a conduit having a first end for receiving reduced pressure and a second end. The apparatus further includes a scaffold. The scaffold has opposing surfaces for positioning adjacent the incisional walls and is fluidly coupled to the second end of the conduit for receiving the reduced pressure. The scaffold is generally elongated in shape and has a thickness between the opposing surfaces that is sufficiently thin for positioning within the incisional wound. The apparatus further includes an internal manifold that has a primary flow channel extending generally longitudinally within the scaffold and between the opposing surfaces of the scaffold. The internal manifold is fluidly coupled to the second end of the conduit. The application of the reduced pressure through the scaffold and the internal manifold induces tissue apposition between the incisional walls.

Systems, apparatus, and methods related to wound closure devices comprising one or more microstructures are described herein. In some embodiments, the wound closure devices include a backing and a microstructure array. The microstructure array may include a first portion, a second portion, and a bridge portion. The first portion and the second portion each include one or more microstructures configured to penetrate tissue. Additionally, the first portion and the second portion each include one or more expandable portions such that the wound closure device is configured to expand in length. The wound closure device is configured to grip tissue surrounding a wound to either close the wound or secure the tissue in place.

A compression device includes an adhesion sheet including an adhesion surface; and a compression member mounted on the adhesion sheet and configured to compress a biological surface. The compression member includes a fixing portion fixed to the adhesion sheet on a side of the sheet opposite the adhesion surface in a thickness direction, and a compression main body portion provided in a portion of the compression member, in a plan view seen along the thickness direction, that does not overlap the adhesion sheet. The compression main body is configured to protrude or be protrusible further toward one side in the thickness direction than the adhesion surface. The adhesion sheet includes a first portion to which the fixing portion is fixed and a second portion to which the fixing portion is not fixed. The second portion is provided on at least a compression main body portion side of the adhesion sheet.

A method of reinforcing subcutaneous fragile tissue includes obtaining an absorbable surgical mesh having top and bottom major surfaces, the absorbable surgical mesh including a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The method includes making an incision in a patient's skin for exposing subcutaneous fragile tissue, using one or more absorbable adhesives for adhering the bottom major surface of the absorbable surgical mesh to the subcutaneous fragile tissue, creating an incision through the stitching zone of the absorbable surgical mesh and into the subcutaneous fragile tissue, performing a surgical procedure through the incision, and passing an absorbable suture through the stitching zone of the absorbable surgical mesh and the fragile tissue for closing the incision.