A biodegradable based polymers for the production of biodegradable medical applications is provided. The biobased material has a copolymer constituted by dextran modified with glycidyl methacrylate and poly (#-caprolactone) modified with 2-isocyanatoethylmethacrylate, which are combined in different formulations and used to produce membranes, 3-D scaffolds and hollow tubes that can be used as biomedical devices for diverse applications such as drug delivery systems, tissue engineering scaffolds, repair and regeneration of peripheral nerves, among others.

The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.

The present disclosure relates to an apparatus for manufacturing a nerve conduit, more particularly to an apparatus for manufacturing a porous nerve conduit using glass fibers whereby microchannels are formed using the space between the glass fibers and the defective rate and location-dependent variation of each nerve conduit can be minimized through uniform decompression during the manufacture. The nerve conduit manufactured according to the present disclosure can be manufactured to have various diameters and lengths to be applicable to in vitro and in vivo researches on nerves.

Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth

A device may include a shaft with a dispensing channel, an evacuating channel, a proximal end, and a distal end. The device may further include an enclosure attached to the distal portion of the shaft, the enclosure having a first portion and a second portion that form a bore when the enclosure is closed. The device may further include a handle attached to the proximal end of the shaft, which is configured to open and close the enclosure. A method of delivering a solution to a nerve repair site may include obtaining such a device, closing its enclosure around the nerve repair site, delivering one or more solutions through the dispensing channel to the nerve repair site, removing one or more solutions through the evacuating channel from the nerve repair site, and opening the enclosure to remove it from the nerve repair site.

Disclosed is a peripheral nerve fixing apparatus, which includes: a suction unit configured to provide a negative pressure to a peripheral nerve at an end portion thereof to fix the peripheral nerve; and a negative pressure generating unit having a vacuum pump for generating a negative pressure and connected to the suction unit so that the negative pressure is provided to the suction unit, wherein at one surface of the end portion of the suction unit, the suction unit includes: a fixing unit provided to contact the peripheral nerve to keep a stable fixed state; and a suction hole formed in the fixing unit so that the negative pressure is provided to the peripheral nerve therethrough.

At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. An electrode is implanted in a muscle of each pair and electrically connected to a motor controller of the device, thereby simulating proprioceptive sensory feedback from the device.

The present disclosure relates to a device for assisting in communicably coupling a first organ body with a second organ body by employing a plurality of arc-shaped tissue connector devices comprising a tissue connector body with a proximal and distal end, and a method for manufacturing such a device. The device comprises a curved frame having a principle axis and configured to embrace, at least partially, the first organ body, the curved frame configured to receive a plurality of tissue connector devices which extend from a proximal end thereof coupled to the curved frame and terminate in a free distal end. The disclosure further relates to a tissue connector device, a holder for tissue connector devices and a tissue-collar manipulating device, and a method of coupling a first and a second organ body using such device.

A severed nerve may be surgically rejoined and severed axons fused via sequential administrations of solutions. The solutions may include a priming solution comprising methylene blue in a Ca.sup.2+-free saline solution, a fusion solution comprising about 50% (w/w) PEG, and a sealing solution comprising Ca.sup.2+-containing saline. The PEG fusion solution may be applied in a nerve treatment device configured to isolate the injured segment of the nerve. The device may include a containment chamber for creating a fluid containment field around the anastomosis. The device may have slits, slots, and/or apertures in opposing endwalls of the device designed to receive the nerve. The device may have an open bath configuration or may include separable lower and upper bodies to create a closed bath configuration. The device may include one or more fluid ports in fluid communication with the containment chamber for introducing and/or removing fluid.

Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.