A neurovascular catheter extension segment is provided, such as for distal neurovascular access or aspiration. The neurovascular catheter extension segment includes 1) an elongate flexible control wire having a proximal end and a distal end and 2) a tubular extension segment having a side wall defining a central lumen carried by the distal end of the control wire. The side wall of the tubular extension segment includes a tubular inner liner, a tie layer separated from the lumen by the inner liner, a helical coil surrounding the tie layer, and an outer jacket surrounding the helical coil. The extension segment may be introduced into the proximal end of a neurovascular catheter and advanced distally to extend beyond the catheter and thereby extend the reach of the catheter.

An occlusion device that includes an inner embolic element with a proximal section and a distal section, wherein the distal section has a first stiffness and the proximal section has a second stiffness. An expandable mesh is included that is capable of being transformed between a collapsed position and an expanded position, wherein the expandable mesh is disposed over a portion of the proximal section of the inner embolic device and the first stiffness is greater than the second stiffness.

A device for occluding an atrial appendage includes a catheter-deliverable epicardial implant that is detachably secured to a delivery device. The implant includes an inflatable cuff that is positionable about the atrial appendage to an extent that, when adjustably inflated, the cuff physiologically occludes the atrial appendage. Such occlusion addresses health risks associated with atrial fibrillation and cardiac rhythm disorder.

In a method for intermittently occluding the coronary sinus, in which the coronary sinus is occluded using an occlusion device, the fluid pressure in the occluded coronary sinus is continuously measured and stored, the fluid pressure curve is determined as a function of time, and the occlusion of the coronary sinus is triggered and/or released as a function of at least one characteristic value derived from the measured pressure values. The pressure increase and/or pressure decrease per time unit each occurring at a heart beat are used as characteristic values.

An aneurysm closure clip along with a system and method for use by a physician in delivering the closure clip into the vasculature of a patient is disclosed. The closure clip delivery system comprises a delivery tube in the form of a catheter, a guide wire, and a detachable closure clip. The closure clip includes a proximal side and a distal side. The distal side comprises at least two winged elements that interact with the wall of the body vessel to hold the clip in place after delivery. The proximal side includes a seal element and a guide bar. The guide bar is in communication with the guide wire during delivery. The seal element forms a barrier between the aneurysm and the rest of the body vessel, thereby, reducing any pressure exerted on the aneurysm. The seal element and optionally the winged elements include a material layer comprised of bioremodelable material, such as an extracellular matrix material (ECM).

Embodiments disclosed herein include an embolization material. The embolication material includes a tubular strand, with an outer surface, having a distal end and a proximal end, wherein the outer surface defines one or more slits.

A closure mechanism for closing a tubular portion of a graft that includes a closure element having aperture or looped ends. The closure element is provided around the circumference of a tubular length of graft material and is attached thereto. The closure element is biased into an annular profile by threading a release element through the ends holding them together. In its annular profile, the closure element thus holds the lumen of the tubular length of graft material in an open configuration. Withdrawal of the release element causes the closure element to take on a flat/linear profile, pulling the lumen closed as it does so. The closure mechanism can be used in a vascular implant such as a graft, stent graft, including tubular, bifurcated, and branched stent grafts, an occlusion device, or the like.

A system and method of delivering and detaching an implant within a body of a patient is described. A tether connects an implant with a delivery device. The delivery device includes a heater coil through which the tether passes. The inner diameter of the heater coil is about the same size or slightly larger than the outer diameter of the tether, allowing the tether to more efficiently break the tether during delivery.

A coupling device, set to be linked to an interventional delivery system, for coupling and releasing a medical implant. The coupling device comprises a generally tubular channel sized and shaped to be conducted in an intravascular catheter and a pivot extended in and along the generally tubular channel having a distal end comprising a lower surface for applying pushing force a medical implant and an upper surface, mounted above the lower generally tubular surface and having at least one niche for receiving at least one anchoring element of the medical element so that a tip of each the anchoring element is placed between the lower and upper surfaces.

A method and apparatus for suture-less placement of an occluding patch in which release of the device can be accelerated. In one embodiment, an inactive form of an adhesive is applied on the area of the patch that will come into contact with cardiac tissue; this allows for the introduction and necessary manipulation of the catheter system until activation of the adhesive occurs. In accordance with one aspect of the invention, the adhesive properties of certain polymeric materials are relied upon rather than their ability to cure or harden into a specific shape. In another embodiment, the patch is immediately released utilizing a detaching mechanism on the balloon or the balloon catheter which supports the patch; the patch along with the inflated balloon remain on the cardiac structure occluding the opening.