A proximal delivery catheter includes a proximal handle assembly, an elongated catheter body defining a longitudinal axis and extending distally from the proximal handle assembly, and a drive wire movably positioned within the elongated catheter body. A release pin assembly is coupled to a distal end of the drive wire. The release pin assembly including a release pin and a release pin housing positioned outward from the release pin. A shaft spring is positioned outward from the release pin housing. The shaft spring includes an annular portion wherein the release pin housing is configured and adapted to interfere with the annular portion of the shaft spring. A distal clip assembly is removably connected to the distal end of the elongated catheter body. The proximal delivery catheter is configured to transmit linear motion along and torsion about the longitudinal axis to at least a portion of the distal clip assembly.

A proximal delivery catheter includes a proximal handle assembly, an elongated catheter body defining a longitudinal axis and extending distally from the proximal handle assembly, and a drive wire movably positioned within the elongated catheter body. A release pin assembly is coupled to a distal end of the drive wire. The release pin assembly including a release pin and a release pin housing positioned outward from the release pin. A shaft spring is positioned outward from the release pin housing. The shaft spring includes an annular portion wherein the release pin housing is configured and adapted to interfere with the annular portion of the shaft spring. A distal clip assembly is removably connected to the distal end of the elongated catheter body. The proximal delivery catheter is configured to transmit linear motion along and torsion about the longitudinal axis to at least a portion of the distal clip assembly.

A system for treating tissue includes a cap mounted over a distal end of an endoscope, a clip mountable over the cap and including first and second jaws movably connected to one another between an insertion configuration, in which the first and second jaws extend over the cap to receive a target tissue therebetween, a review configuration, in which at least a portion of the clip extends into a field of view of the optical system of an endoscope, and a deployed configuration in which the clip is moved distally off of the cap so that the first and second jaws are drawn toward one another. A control element is configured so that movement proximally through the cap via a first distance moves the clip from the insertion configuration to the review configuration and a second distance moves the clip from the review configuration to the deployed configuration.

A system for treating tissue includes a cap mounted over a distal end of an endoscope, a clip mountable over the cap and including first and second jaws movably connected to one another between an insertion configuration, in which the first and second jaws extend over the cap to receive a target tissue therebetween, a review configuration, in which at least a portion of the clip extends into a field of view of the optical system of an endoscope, and a deployed configuration in which the clip is moved distally off of the cap so that the first and second jaws are drawn toward one another. A control element is configured so that movement proximally through the cap via a first distance moves the clip from the insertion configuration to the review configuration and a second distance moves the clip from the review configuration to the deployed configuration.

Apparatus and methods are provided for performing a medical procedure using a stapler apparatus including a reusable handle portion including a shaft include proximal and distal ends, a disposable end effector attached to the distal end of the shaft of the reusable handle carrying one or more staples. For example, the end effector may include first and second jaws movable relative to one another between open and closed positions, the first jaw carrying a cartridge which includes the one or more staples. A Doppler sensor, cutting element, thermal element, and/or grasper may be provided on the end effector. The end effector is introduced into a patient's body, tissue is positioned/locked between the jaws, and a plurality of staples are deployed into the tissue. The Doppler sensor is used to confirm that blood flow has discontinued in the stapled tissue, and the cutting element is actuated to sever the stapled tissue.

A tissue clipping apparatus, comprises a flexible, elongate member, a proximal end of which remains external to the body accessible to a user while a distal end of the flexible member is inserted into the body to a location adjacent to target tissue to be clipped and a control wire extending through the flexible member in combination with a capsule releasably coupled to a distal end of the flexible member and a clip a proximal portion of which is received within the capsule. A joint releasably coupling the clip to the control wire, includes a yoke extending around a proximal end of the clip and a frangible link which fails when subject to a predetermined force to separate the clip from the control wire.

A tissue clipping apparatus, comprises a flexible, elongate member, a proximal end of which remains external to the body accessible to a user while a distal end of the flexible member is inserted into the body to a location adjacent to target tissue to be clipped and a control wire extending through the flexible member in combination with a capsule releasably coupled to a distal end of the flexible member and a clip a proximal portion of which is received within the capsule. A joint releasably coupling the clip to the control wire, includes a yoke extending around a proximal end of the clip and a frangible link which fails when subject to a predetermined force to separate the clip from the control wire.

A surgical clamp may have two elongated members with a bight portion that joins the two elongated members at a proximal end of the clamp and that may bias the two elongated members in an open position at a distal end. The bight portion may have one or more engagement features, such as a slotted aperture or other engagement or coupling feature. A clasp mechanism at the distal end of the clamp may have a male or first component disposed on or adjacent one of the two elongated members and a female or second component disposed on or adjacent the other of the two elongated members at the distal end of the clamp.

A surgical clamp may have two elongated members with a bight portion that joins the two elongated members at a proximal end of the clamp and that may bias the two elongated members in an open position at a distal end. The bight portion may have one or more engagement features, such as a slotted aperture or other engagement or coupling feature. A clasp mechanism at the distal end of the clamp may have a male or first component disposed on or adjacent one of the two elongated members and a female or second component disposed on or adjacent the other of the two elongated members at the distal end of the clamp.

Valve apparatuses and methods are provided for controlling blood flow in a vein of an individual. One example valve apparatus includes at least one valve member configured to be positioned adjacent to an exterior surface of a vein of an individual and outside of a lumen of the vein, at least one sensor configured to be positioned adjacent to the exterior surface of the vein, and a controller configured to receive, from the at least one sensor, a signal representing one or more characteristics of blood flow through the lumen, determine a direction of the blood flow based on the one or more characteristics, and in response to the determined direction of the blood flow being away from a heart of the individual, activate the at least one valve member to occlude blood flow through the lumen away from the heart.