Some embodiments of the present disclosure may provide an end effector instrument. The end effector instrument may include: an end effector device, the end effector device comprising an effector portion configured to perform a specified operation, and a delivery device connected to the end effector device, the delivery device being configured to deliver the end effector device to a target region where the specified operation is to be performed. The delivery device may include an operation portion. The operation portion may be configured to drive the effector portion to perform the specified operation.

Some embodiments of the present disclosure may provide an end effector instrument. The end effector instrument may include: an end effector device, the end effector device comprising an effector portion configured to perform a specified operation, and a delivery device connected to the end effector device, the delivery device being configured to deliver the end effector device to a target region where the specified operation is to be performed. The delivery device may include an operation portion. The operation portion may be configured to drive the effector portion to perform the specified operation.

A system for treating tissue includes a clip assembly including clip arms movable relative to a channel of a capsule so that the clip arms are movable between a tissue receiving configuration and a tissue clipping configuration. Also, the system includes an applicator releasably coupleable to the clip assembly. The applicator includes a bushing and a control member extending therethrough. The bushing includes deflectable fingers, each of the fingers including an engaging feature at a distal end thereof to engage a corresponding engaging feature of the capsule of the clip assembly and assembled with a pusher element configured to push the fingers to a radially outward position. The pusher element includes a U-shaped portion curving into a channel of the bushing and a longitudinal portion extending distally therefrom. A cam washer is slidable over a length of the control member and positioned distally of the U-shaped portion.

A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

An endoscopic clip device for closure of a mucosal defect or transmural perforation in a gastrointestinal wall may include a sleeve and a clip disposed at least partially within and coupled to the sleeve. The clip may be configured for reversibly moving between an open configuration for positioning relative to the wall and a closed configuration for closing the defect or perforation. The clip may include a first clip arm configured for engaging the mucosal and submucosal layers of the wall and including a first needle extending to a distal end of the first clip arm and configured for advancing through the mucosal layer and into at least the submucosal layer, and a second clip arm disposed opposite the first clip arm and configured for engaging the mucosal layer. The device may be configured for advancing through an operative channel of an endoscope or overtube having a tortuous shape.

An endoscopic clip device for closure of a mucosal defect or transmural perforation in a gastrointestinal wall may include a sleeve and a clip disposed at least partially within and coupled to the sleeve. The clip may be configured for reversibly moving between an open configuration for positioning relative to the wall and a closed configuration for closing the defect or perforation. The clip may include a first clip arm configured for engaging the mucosal and submucosal layers of the wall and including a first needle extending to a distal end of the first clip arm and configured for advancing through the mucosal layer and into at least the submucosal layer, and a second clip arm disposed opposite the first clip arm and configured for engaging the mucosal layer. The device may be configured for advancing through an operative channel of an endoscope or overtube having a tortuous shape.

Surgical clip appliers are provided and includes a channel assembly extending distally from a housing; a clip carrier disposed within said channel assembly and defining a channel and a plurality of windows therein; a plurality of clips slidably disposed within said channel of said clip carrier; a wedge plate reciprocally disposed within said channel assembly, said wedge plate being operatively connected to said handles and including a plurality of apertures formed along a length thereof; and a clip follower slidably disposed within said channel of said clip carrier and disposed proximally of said plurality of clips, said clip follower being configured and adapted for selective engagement with said windows of said clip carrier and said apertures of said wedge plate. The clip follower is configured and adapted to urge said plurality of clips, in a distal direction relative to said clip carrier, upon reciprocal movement of said wedge plate.

A cartridge includes an insertion port into which at least a part of an applicator is insertable, a first region for accommodating a clip unit that can be releasably coupled to the applicator, and a second region for removing a coupling member from the applicator.