The present application provides a heat exchanger and a manufacturing method of a heat exchanger. The heat exchange includes a metal substrate having a fluid channel for circulating a heat exchange medium. The heat exchanger includes a coating having a rare earth conversion coating and a hydrophilic coating. The rare earth conversion coating is arranged to cover at least part of a surface of the metal substrate, and the rare earth conversion coating includes a rare earth element-containing compound. At least part of the hydrophilic coating is further away from the metal substrate than the rare earth conversion coating. A surface of the heat exchanger is hydrophilic, which is conducive to the discharge of condensate water, and can improve corrosion resistance and prolong a service life of the heat exchanger.

The present invention relates to silicon coated metal microparticles in which at least a part of a surface of a metal microparticle composed of at least one of metal elements or metalloid elements is coated with silicon, wherein the silicon coated metal microparticles are a product obtained by a reduction treatment of silicon compound coated precursor microparticles in which at least a part of a surface of a precursor microparticle containing a precursor of the metal microparticles is coated with a silicon compound, or silicon doped precursor microparticles containing a precursor of the metal microparticles. Because it is possible particularly to strictly control a particle diameter of the silicon compound coated metal microparticle by controlling conditions of the reduction treatment, design of a more appropriate composition can become facilitated, compared with a conventional composition, in terms of diversified usages and desired properties of silicon compound coated metal microparticles.

The present invention relates to silicon coated metal microparticles in which at least a part of a surface of a metal microparticle composed of at least one of metal elements or metalloid elements is coated with silicon, wherein the silicon coated metal microparticles are a product obtained by a reduction treatment of silicon compound coated precursor microparticles in which at least a part of a surface of a precursor microparticle containing a precursor of the metal microparticles is coated with a silicon compound, or silicon doped precursor microparticles containing a precursor of the metal microparticles. Because it is possible particularly to strictly control a particle diameter of the silicon compound coated metal microparticle by controlling conditions of the reduction treatment, design of a more appropriate composition can become facilitated, compared with a conventional composition, in terms of diversified usages and desired properties of silicon compound coated metal microparticles.

Rare earth compound particles are prepared by a step of heating an aqueous solution containing rare earth metal ions and urea to form a rare earth compound by a reaction of a hydrolysis product of urea, and the rare earth metal ions. In the heating step, heating the aqueous solution into which an acetylene glycol-ethylene oxide adduct is added.

This disclosure relates generally to production of stable and uniformly dispersed nanoparticles. Convention methods of nanoparticle production includes a two-step approach that utilizes additives or surface modifiers. The disclosed method avoids using any additives/surface modifiers owing to the environmental and economic implications. The method includes employing process conditions in a reaction to manipulate electrostatic double layer repulsive forces among nanoparticles to impart the dispersion stability of nanoparticles. The reaction includes pouring pH modifier dropwise into metal precursor solution with vigorous stirring forming metal hydroxide solution, while maintain ranges for concentration of metal precursor solution about 0.15M to 0.75 M, pH about 9 to 12, ionic conductivity about 50 to 200 mS/cm, stirring speed about 800 to 1200 rpm, aging time 6 to 24 hours. The metal hydroxide solution is heated with temperature maintained in range of 100 to 400° C. to obtain nanoparticle slurry comprising a stable suspension of the nanoparticles.

This disclosure relates generally to production of stable and uniformly dispersed nanoparticles. Convention methods of nanoparticle production includes a two-step approach that utilizes additives or surface modifiers. The disclosed method avoids using any additives/surface modifiers owing to the environmental and economic implications. The method includes employing process conditions in a reaction to manipulate electrostatic double layer repulsive forces among nanoparticles to impart the dispersion stability of nanoparticles. The reaction includes pouring pH modifier dropwise into metal precursor solution with vigorous stirring forming metal hydroxide solution, while maintain ranges for concentration of metal precursor solution about 0.15M to 0.75 M, pH about 9 to 12, ionic conductivity about 50 to 200 mS/cm, stirring speed about 800 to 1200 rpm, aging time 6 to 24 hours. The metal hydroxide solution is heated with temperature maintained in range of 100 to 400° C. to obtain nanoparticle slurry comprising a stable suspension of the nanoparticles.

The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following injury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, preventing adverse ventricular remodeling following myocardial infarction.

Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.