Disclosed is a skin treatment device, including: a support main body; a rotating part mounted on one surface of the support main body to be rotatable about a rotating shaft; a plurality of elastic parts which have one ends fixed to the support main body and inserted into the rotating part and are disposed to correspond to a rotation direction of the rotating part, and a needle holder coupled to tip ends of the elastic parts. When the rotating part rotates, the plurality of elastic parts are bent in the rotation direction so that relative positions of tip ends of the elastic parts vary.

Disclosed are a needle tip mounted in a cartridge form (in a replaceable manner) to a hand piece of the skin treatment apparatus and allowing a drug to be injected deeply into an invaded potion, and a skin treatment apparatus having the needle tip mounted thereon. The needle tip includes a casing hollow in a vertical direction; a needle unit disposed in the casing and reciprocating in the vertical direction; and at least one sealing member disposed between the casing and the needle unit, wherein the needle unit includes: a housing disposed inside the casing; and at least one needle electrode disposed in the housing of the needle unit and extending in the vertical direction, wherein the at least one sealing member closes a space between the casing and the housing of the needle unit in the vertical direction.

A hair follicle implant device includes a needle holding assembly configured to hold a plurality of needles and a needle guide slidably coupled thereto and configured to provide a skin stop surface while guiding the plurality needles. A plurality of pistons is configured to slide within a respective one of the plurality of needles. A piston base is slidably coupled to the needle holding assembly and is configured to hold the pistons to slide within the plurality of needles when actuated during implantation. A spring, carried between the needle holding assembly and the piston base, is configured to bias the piston base in a retracted position, wherein the spring is offset from a central axis of the piston base. The needle holder holds the plurality of needles in the staggered arrangement offset from the central axis of the piston base.

The present invention includes a surgical stapler having a staple cartridge, an anvil, and a cutting member having a cutting surface, wherein the cutting member is relatively movable with respect to the anvil and the staple cartridge. In at least one embodiment, one of the anvil and the staple cartridge defines a slot which is configured to receive at least a portion of the cutting member and guide the cutting member as it is moved relative to the anvil and the staple cartridge. In these embodiments, the slot can define a path having linear and/or curved portions. In various embodiments, the path can include a curved portion having a first portion that extends away from the shaft axis and a second portion that extends toward the axis. In one embodiment, the path can include a curved portion defined by an arc corresponding to an angle greater than 90 degrees.

An electroporation device with a needle array removably attached thereto, the needle array having a body, a shroud movable with respect to the body between a rest position and one or more actuated positions, and an auto-lock assembly. Where the auto-lock assembly is adjustable between a locked configuration, where the shroud is not movable with respect to the body, and an unlocked configuration, where the shroud is movable with respect to the body, and where biasing the shroud from the rest position to the one or more actuated positions and back to the rest position adjusts the auto-lock from the unlocked configuration to the locked configuration.

Influenza vaccines are administered using solid biodegradable microneedles. The microneedles are lubricated from the influenza vaccine in combination with solid excipient(s) and, after penetrating the skin, they dissolve in situ and release the vaccine to the immune system. The influenza vaccine is (i) a purified influenza virus surface antigen vaccine, rather than a live vaccine or a whole-virus or split inactivated vaccine (ii) an influenza vaccine prepared from viruses grown in cell culture, not eggs, (iii) a monovalent influenza vaccine e.g. for immunising against a pandemic strain, (iv) a bivalent vaccine, (v) a tetravalent or >4 -valent vaccine, (vi) mercury-free vaccine, or (vii) a gelatin-free vaccine.

A device for delivery of material to a biological subject, the device including a base and a number of projections extending from the base, each projection including a tip for penetrating tissue of the biological subject, at least a portion of at least one of the projections being coated with a non-liquid coating including the material. At least the tip of at least one of the coated projections may have a convex effective profile. The device may be for delivery of material to a dermal layer of the biological subject. In another aspect an applicator for applying the device to the biological subject applies a preload force to the tissue such that the force at least partially compresses a subcutaneous tissue layer of the biological subject prior to application of the device, and applies the device with a predetermined velocity, wherein tissue stiffness is maintained and/or the projections penetrate the tissue to a predetermined depth.

An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

A method of providing therapeutic treatment by delivering therapeutic aptamers locally to a target site using microneedles includes providing complementary sequence modified microneedles by reacting a complementary sequence (CS) with a polymer thereby forming a covalent bond between the polymer and the CS, forming microneedle patches using an initial casting solution consisting of the polymer, the therapeutic aptamer, and a covalent bond between a complementary sequence (CS) and the polymer, thereby loading the therapeutic aptamer into the microneedles, each microneedle having a base, shaft and tip, physically binding the therapeutic aptamer to the CS, inserting the microneedles into the tissue such that the tips and shafts are embedded into the target site and the bases are on a surface of the target site, and sustained release of the aptamer to the target site due to dissociation of the aptamer from the CS over time.